Nanoscale MOFs: From synthesis to drug delivery and theranostics applications

Ding, Mengli; Liu, Wenbo; Gref, Ruxandra

doi:10.1016/j.addr.2022.114496

Cited by 101 publications

(67 citation statements)

References 201 publications

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“…Photodynamic therapy (PDT) has been demonstrated as a minimally invasive method to treat various types of cancer, including breast cancer, melanoma, and lung cancer ( Tang et al, 2021 ; Ding et al, 2022 ; Jia et al, 2022 ; Obaid et al, 2022 ; Pan et al, 2022 ; Zhang et al, 2022 ). The photosensitizers can be activated under a light source to generate reactive oxygen species (ROS) to kill cancer cells.…”

Section: Photothermal Therapy On Bc Metastasismentioning

confidence: 99%

Recent advances in photothermal therapy-based multifunctional nanoplatforms for breast cancer

Sun

Zhao

et al. 2022

Front. Chem.

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Breast cancer (BC) is one of the most common cancers in women worldwide; however, the successful treatment of BC, especially triple-negative breast cancer (TNBC), remains a significant clinical challenge. Recently, photothermal therapy (PTT), which involves the generation of heat under irradiation to achieve photothermal ablation of BC with minimal invasiveness and outstanding spatial–temporal selectivity, has been demonstrated as a novel therapy that can overcome the drawbacks of chemotherapy or surgery. Significantly, when combining PTT with chemotherapy and/or photodynamic therapy, an enhanced synergistic therapeutic effect can be achieved in both primary and metastatic BC tumors. Thus, this review discusses the recent developments in nanotechnology-based photothermal therapy for the treatment of BC and its metastasis to provide potential strategies for future BC treatment.

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Section: Photothermal Therapy On Bc Metastasismentioning

confidence: 99%

Recent advances in photothermal therapy-based multifunctional nanoplatforms for breast cancer

Sun

Zhao

et al. 2022

Front. Chem.

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“…As a research hotspot in the field of materials, metal–organic frameworks (MOFs) have promising application prospects in many fields, for instance energy storage, catalysis, gas separation, electronic devices, sensors, and drug delivery . With the advantages of higher porosity, more active sites, and various organic functional groups, MOFs are gradually used to remove hazardous pollutants and heavy-metal ions. − Yuan et al removed Cr(VI) from aqueous solutions by modifying the bimetallic MOF-derived carbon material Cu@MIL-53(Fe) .…”

Section: Introductionmentioning

confidence: 99%

Design of Zr-MOFs by Introducing Multiple Ligands for Efficient and Selective Capturing of Pb(II) from Aqueous Solutions

Liu

et al. 2023

ACS Appl. Mater. Interfaces

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The existence of lead ions seriously affects the quality of many metal products in metallurgical enterprises. Currently, the various methods of lead-ion removal tried by researchers will affect valuable metals in the removal process, thus resulting in low economic efficiency. In this study, a novel metal–organic framework adsorbent (UiO-FHD) which efficiently and selectively captures lead ions is developed by introducing multiple ligands. The maximum adsorption capacity of lead ions is 433.15 mg/g at pH 5. The adsorption process accords with the pseudo-second-order kinetic and the Langmuir isotherm models at room temperature. Thermodynamic experiments indicate that the removal of Pb(II) is facilitated by appropriate temperature reduction. The performance tests indicate that UiO-FHD maintains a high removal rate of 90.35% for Pb(II) after four consecutive adsorption–desorption cycles. The distribution coefficient of lead ions (26.7 L/g) shows that UiO-FHD has excellent selective adsorption for lead ions. It is revealed that the chelation of the sulfhydryl groups and the electrostatic interaction of the hydroxyl groups are the dominant factors to improve the removal rate of Pb(II) by density functional theory calculations. This study clarifies the value of self-designed novel organic ligands in metal–organic framework materials that selectively capture heavy-metal ions.

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“…Since their discovery in 1989, metal organic frameworks (MOFs), built from organic linkers and metal ions, have attracted growing interest for a variety of applications, including catalysis, gas storage, energy, and more recently, biomedicine [ 1 , 2 , 3 , 4 , 5 , 6 ]. Nanoscale MOFs (nanoMOFs) were employed in the drug delivery field for the treatment of cancer, infections, diabetes, wounds, and other severe diseases [ 7 , 8 , 9 , 10 ]. NanoMOFs have advantageous features for drug loading, such as versatile compositions and topologies, and large surface areas.…”

Section: Introductionmentioning

confidence: 99%

Acetic Acid-Modulated Room Temperature Synthesis of MIL-100 (Fe) Nanoparticles for Drug Delivery Applications

Ding

Qiu

Rouzière

et al. 2023

IJMS

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Due to their flexible composition, large surface areas, versatile surface properties, and degradability, nanoscale metal organic frameworks (nano MOFs) are drawing significant attention in nanomedicine. In particular, iron trimesate MIL-100 (Fe) is studied extensively in the drug delivery field. Nanosized MIL-100 (Fe) are obtained mostly by microwave-assisted synthesis. Simpler, room-temperature (RT) synthesis methods attract growing interest and have scale-up potential. However, the preparation of RT MIL100 is still very challenging because of the high tendency of the nanoparticles to aggregate during their synthesis, purification and storage. To address this issue, we prepared RT MIL100 using acetic acid as a modulator and used non-toxic cyclodextrin-based coatings to ensure stability upon storage. Hydrodynamic diameters less than 100 nm were obtained after RT synthesis, however, ultrasonication was needed to disaggregate the nanoparticles after their purification by centrifugation. The model drug adenosine monophosphate (AMP) was successfully encapsulated in RT MIL100 obtained using acetic acid as a modulator. The coated RT MIL100 has CD-exhibited degradability, good colloidal stability, low cytotoxicity, as well as high drug payload efficiency. Further studies will focus on applications in the field of cancer therapy.

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Nanoscale MOFs: From synthesis to drug delivery and theranostics applications

Cited by 101 publications

References 201 publications

Recent advances in photothermal therapy-based multifunctional nanoplatforms for breast cancer

Recent advances in photothermal therapy-based multifunctional nanoplatforms for breast cancer

Design of Zr-MOFs by Introducing Multiple Ligands for Efficient and Selective Capturing of Pb(II) from Aqueous Solutions

Acetic Acid-Modulated Room Temperature Synthesis of MIL-100 (Fe) Nanoparticles for Drug Delivery Applications

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