Nanoscale metal–organic frameworks for tumor phototherapy

Huang, Xuan; Sun, Xu; Wang, Weili; Shen, Qing; Shen, Qian; Tang, Xiaoyong; Shao, Jinjun

doi:10.1039/d1tb00349f

Cited by 45 publications

(33 citation statements)

References 169 publications

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“…As shown in Figure 1 , PS is excited by light irradiation, and the electronic state changes from the ground state (S 0 ) to the singlet excited state (S n ) and then relaxes to the lowest energy level of the singlet excited state (S 1 ) through internal conversion (IC). The PS at the S 1 state can consume energy in three ways, resulting in diverse outcomes ( 30 , 31 ). 1).…”

Section: The Principle and Damage Mechanism Of Photodynamic Therapymentioning

confidence: 99%

Current Strategies for Tumor Photodynamic Therapy Combined With Immunotherapy

Hua

Gan

et al. 2021

Front. Oncol.

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Photodynamic therapy (PDT) is a low invasive antitumor therapy with fewer side effects. On the other hand, immunotherapy also has significant clinical applications in the treatment of cancer. Both therapies, on their own, have some limitations and are incapable of meeting the demands of the current cancer treatment. The efficacy of PDT and immunotherapy against tumor metastasis and tumor recurrence may be improved by combination strategies. In this review, we discussed the possibility that PDT could be used to activate immune responses by inducing immunogenic cell death or generating cancer vaccines. Furthermore, we explored the latest advances in PDT antitumor therapy in combination with some immunotherapy such as immune adjuvants, inhibitors of immune suppression, and immune checkpoint blockade.

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Section: The Principle and Damage Mechanism Of Photodynamic Therapymentioning

confidence: 99%

Current Strategies for Tumor Photodynamic Therapy Combined With Immunotherapy

Hua

Gan

et al. 2021

Front. Oncol.

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“…In recent years, PDT has attracted dramatic attention due to its minimal side effects on normal tissues, non-invasiveness, high tumor selectivity, and excellent antitumor capability. [89][90][91] In the process of PDT, the photosensitizer is stimulated by the appropriate light source to generate toxic ROS, including singlet oxygen…”

Section: Oxygen-enhanced Pdtmentioning

confidence: 99%

“…In recent years, PDT has attracted dramatic attention due to its minimal side effects on normal tissues, non‐invasiveness, high tumor selectivity, and excellent antitumor capability. [ 89–91 ] In the process of PDT, the photosensitizer is stimulated by the appropriate light source to generate toxic ROS, including singlet oxygen ( 1 O 2 ), superoxide radical (O 2 •− ), hydroxyl radical ( • OH), etc. [ 92–94 ] The produced ROS could destroy protein and nucleic acids molecules, further inducing apoptosis or necrosis of pathological cells for the treatment of diseases, such as cancer.…”

Section: Applications In Cancer Therapymentioning

confidence: 99%

Hollow Mesoporous Manganese Oxides: Application in Cancer Diagnosis and Therapy

Qing

Liu

et al. 2022

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The precision, minimal invasiveness, and integration of diagnosis and treatment are critical factors for tumor treatment at the present. Although nanomedicine has shown the potential in tumor precision treatment, nanocarriers with high efficiency, excellent targeting, controlled release, and good biocompatibility still need to be further explored. Hollow mesoporous manganese oxides nanomaterials (HM‐MONs), as an efficient drug delivery carrier, have attracted substantial attention in applications of tumor diagnosis and therapy due to their unique properties, such as tumor microenvironment stimuli‐responsiveness, prominent catalytic activity, excellent biodegradation, and outstanding magnetic resonance imaging ability. The HM‐MONs can not only enhance the therapeutic efficiency but also realize multimodal diagnosis of tumors. Consequently, it is necessary to introduce applications based on HM‐MONs in cancer diagnosis and therapy. In this review, the representative progress of HM‐MONs in synthesis is discussed. Then, several promising applications in drug delivery, bio‐imaging, and bio‐detection are highlighted. Finally, the challenges and perspectives of the anticancer applications are summarized, which is expected to provide meaningful guidance on further research.

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“…At the same time, phototherapy can also trigger stress protection mechanism in cancer cells, which involves increase in heat shock proteins, expression of various pro-survival factors, and increase in angiogenesis signaling molecules, which further lead to increased tolerance of cancer cells towards phototherapy. This in turn limits the efficacy of phototherapy 82 , 83 . Besides this, phototherapy is known to generate heat, which affects the stability of genes 84 .…”

Section: Co-transport Of Regulatory Gene and Photosensitizermentioning

confidence: 99%

Multifunctional co-transport carriers based on cyclodextrin assembly for cancer synergistic therapy

Yi¹,

Liao²,

Zhao³

et al. 2022

Theranostics

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In the past few years, drug delivery systems have been used extensively to improve solubility, stability, and pharmacokinetics of chemotherapeutic drugs. However, traditional delivery systems fail to fulfill the required standard of effectiveness, primarily owing to issues of drug resistance exhibited by cancer cells and inherent differences among the patients. In this regard, combination therapy offers advantages of synergistic mechanism, reduced drug dosage, and enhanced therapeutic effect, which can be effectively utilized for the treatment of cancer. However, different types of therapeutic agents exhibit different pharmacokinetic properties and action targets in vivo , which lead to uncontrollable concentration ratio of therapeutic agents at the lesion site. This in turn causes serious side effects and affects synergistic anticancer effect. Importantly, multifunctional co-delivery systems are characterized by good pharmacokinetic properties, ability to provide targeted delivery, and controlled release in response to tumor microenvironment. Such delivery systems are widely used for co-delivery of therapeutic agents, which further assist in obtaining better synergistic anticancer effect, and can be potentially used for clinical application. Multifunctional co-delivery systems often exhibit complex structures and construction process. Since cyclodextrin is characterized by self-assembly property, it is possible to quickly construct cyclodextrin-based multifunctional co-delivery systems, with convenience and flexibility. The application of cyclodextrin in the construction of multifunctional co-delivery systems for cancer therapy has gained immense attention in the past few years. The present study provided overview of latest progress in the field of cyclodextrin-based multifunctional co-delivery systems for cancer synergistic therapy.

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Nanoscale metal–organic frameworks for tumor phototherapy

Abstract: Metal-Organic Frameworks (MOFs) are constructed from metal ions/cluster nodes and functional organic ligands through coordination bonds. Owing to the advantages of diverse synthetic methods, easy modification after synthesis, large adsorption...

Cited by 45 publications

References 169 publications

Current Strategies for Tumor Photodynamic Therapy Combined With Immunotherapy

Current Strategies for Tumor Photodynamic Therapy Combined With Immunotherapy

Hollow Mesoporous Manganese Oxides: Application in Cancer Diagnosis and Therapy

Multifunctional co-transport carriers based on cyclodextrin assembly for cancer synergistic therapy

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