Multifunctional co-transport carriers based on cyclodextrin assembly for cancer synergistic therapy

Abstract

In the past few years, drug delivery systems have been used extensively to improve solubility, stability, and pharmacokinetics of chemotherapeutic drugs. However, traditional delivery systems fail to fulfill the required standard of effectiveness, primarily owing to issues of drug resistance exhibited by cancer cells and inherent differences among the patients. In this regard, combination therapy offers advantages of synergistic mechanism, reduced drug dosage, and enhanced therapeutic effect, which can be effectively utilized for the treatment of cancer. However, different types of therapeutic agents exhibit different pharmacokinetic properties and action targets in vivo , which lead to uncontrollable concentration ratio of therapeutic agents at the lesion site. This in turn causes serious side effects and affects synergistic anticancer effect. Importantly, multifunctional co-delivery systems are characterized by good pharmacokinetic properties, ability to provide targeted delivery, and controlled release in response to tumor microenvironment. Such delivery systems are widely used for co-delivery of therapeutic agents, which further assist in obtaining better synergistic anticancer effect, and can be potentially used for clinical application. Multifunctional co-delivery systems often exhibit complex structures and construction process. Since cyclodextrin is characterized by self-assembly property, it is possible to quickly construct cyclodextrin-based multifunctional co-delivery systems, with convenience and flexibility. The application of cyclodextrin in the construction of multifunctional co-delivery systems for cancer therapy has gained immense attention in the past few years. The present study provided overview of latest progress in the field of cyclodextrin-based multifunctional co-delivery systems for cancer synergistic therapy.

Polysaccharide‐Based Stimulus‐Responsive Nanomedicines for Combination Cancer Immunotherapy

“…They have a hydrophilic surface on the outside and a lipophilic cavity in the middle. [ 347,348 ] The selective modification of the hydroxyl groups on the outer surface of cyclodextrins can confer a specific function. [ 349 ] The hydrophobic spaces in cyclodextrins can be filled by molecules like azobenzene, ferrocene, adamantane, and their derivatives, ADA.…”

Recent advances in aptamer-based therapeutic strategies for targeting cancer stem cells

“…By conjugating multiple components, such as different kinds of tumor-targeting ligands, anticancer drugs, or siRNAs, to a single construct, not only can these multifunctional nanosystems target more cancer cells, but also they can achieve effective synergistic therapeutic treatment [ 71 , 72 ]. Investigations of multifunctional therapeutic strategies are progressing rapidly and provide new opportunities in the treatment of cancer [ 73 , 74 ].…”

Nanoarchitectures to Deliver Nucleic Acid Drugs to Disease Sites

“…A nanoparticle was constructed to deliver both antisense DNA and siRNA simultaneously [103] . Seven antisense DNA strands were connected to β‐cyclodextrin (a cyclic oligosaccharide composed of seven D‐glucose units), which is very conveniently employed for pharmaceutical applications because of many favorable features [104–107] . In order to bind siRNA to these antisense DNA strands, each strand of the siRNA is extended to the 3’‐direction.…”