Nanoprecipitation process: From encapsulation to drug delivery

Rivas, Claudia Janeth Martínez; Tarhini, Mohamad; Badri, Waisudin; Miladi, Karim; Greige‐Gerges, Hélène; Nazari, Qand Agha; Galindo-Rodríguez, Sergio Arturo; Román, Rocío Álvarez; Fessi, Hatem; Elaı̈ssari, Abdelhamid

doi:10.1016/j.ijpharm.2017.08.064

Cited by 477 publications

(265 citation statements)

References 89 publications

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“…The LDBCs having weight ratios of 70:30, 50:50, and 30:70 (in respect to PLA) were formed into aggregates employing a direct dissolution method . Aggregates for LDBCs with ratios of 90:10 were formed using nanoprecipitation . For direct dissolution, 1 mg of LDBC was added to a vial of MilliQ water (1 mL) while stirring followed by sonication to achieve homogeneity.…”

Section: Methodsmentioning

confidence: 99%

Synthesis and characterization of polylactide‐PAMAM “Janus‐type” linear‐dendritic hybrids

Chandrasiri

Abebe

Gupta

et al. 2019

J. Polym. Sci. Part A: Polym. Chem.

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Herein, we present a facile and comprehensive synthetic methodology for the preparation of polyester‐polyamidoamine (PAMAM) (i.e., polyester: polylactide [PLA] (hydrophobic) and polyamidoamine, PAMAM [hydrophilic]) polymers. A library of PLA‐PAMAM linear dendritic block copolymers (LDBCs) in which both l and d, l polylactide were employed in mass ratios of 30:70, 50:50, 70:30, and 90:10 (PLA:PAMAM) were synthesized and analyzed. When placed in aqueous media, the immiscibility of the hydrophilic and hydrophobic segments leads to nanophase‐segregation exhibited as the formation of aggregates (e.g., vesicles, worms, and/or micelles). By employing both stereochemical configurations of PLA, the differentiation in mass ratios of PLA‐PAMAM aided in elucidating the structure–property relationships of the LDBC system and provided a means toward the control of nanoparticle morphology. Transmission electron microscopy and dynamic light scattering afford the size and shape of the nanoparticles with diameters ranging from 10.6 for low mass ratios to 122.4 nm for high mass ratios of PLA‐PAMAM and positive zeta‐potential values between +24.7 mV and +48.2 mV. Furthermore, small‐angle X‐ray scattering (SAXS) studies were employed to obtain more detailed information on the morphological assemblies constructed via direct dissolution. Such insights provide a pathway toward nanomaterials with unique morphologies and tunable properties deemed relevant in the development of next generation biomaterials. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 1448–1459

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Section: Methodsmentioning

confidence: 99%

Synthesis and characterization of polylactide‐PAMAM “Janus‐type” linear‐dendritic hybrids

Chandrasiri

Abebe

Gupta

et al. 2019

J. Polym. Sci. Part A: Polym. Chem.

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“…151 Cells of the mononuclear phagocytic system can recognize the nanocrystal particles in the bloodstream as an exogenous material which results in passive accumulation in liver, spleen, and lung. 61,152 Nanocrystals are generally developed by the "bottomup" (such as Nanomorph™, Soliqs/Abbott), "top-down" technologies (such as Dissocubes ® , SkyePharma) or combination technologies (such as NANOEDGE, Baxter). However, the top-down technique is the procedure of choice for nanocrystals in products developed in the pharmaceutical, cosmetic or clinical trials mainly due to the simple and easy scale-up which better serves the industry.…”

Section: Micellementioning

confidence: 99%

“…54 More examples of herbal loaded NE are presented in Table 1. [57][58][59][60][61][62] Lipid Drug Conjugate (LDC) or Polymer Drug Conjugate (PDC) The union of agents with polymers is a new approach to modify drug property and its pharmacokinetics. LDCs are lipidic drugs that covalently or noncovalently coupled to a lipid moiety, such as diglyceride, phosphoglyceride and fatty acid (Figure 4).…”

mentioning

confidence: 99%

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

Rahman

Othman

Hammadi

et al. 2020

IJN

145

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Many types of research have distinctly addressed the efficacy of natural plant metabolites used for human consumption both in cell culture and preclinical animal model systems. However, these in vitro and in vivo effects have not been able to be translated for clinical use because of several factors such as inefficient systemic delivery and bioavailability of promising agents that significantly contribute to this disconnection. Over the past decades, extraordinary advances have been made successfully on the development of novel drug delivery systems for encapsulation of plant active metabolites including organic, inorganic and hybrid nanoparticles. The advanced formulas are confirmed to have extraordinary benefits over conventional and previously used systems in the manner of solubility, bioavailability, toxicity, pharmacological activity, stability, distribution, sustained delivery, and both physical and chemical degradation. The current review highlights the development of novel nanocarrier for plant active compounds, their method of preparation, type of active ingredients, and their biomedical applications.

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“…This process covers a broad range of applications such as pharmaceutical, food, cosmetic, and textile industries. Among the commonly used coating materials, biodegradable polymers such as polysaccharides (starch and chitosan), proteins (gelatin and bovine serum albumin), polyesters (polylactide [PLA], polylactide‐co‐glycolide [PLGA], and polycaprolactone [PCL]), and polyether (polyethylene glycol [PEG]) are explored in the literature . Moreover, nonbiodegradable stimuli‐responsive polymers are largely studied especially the polymethylmethacrylate derivatives …”

Section: Introductionmentioning

confidence: 99%

“…In the pharmaceutical industry, drug encapsulation plays a major role since it increases the bioavailability of drugs . Moreover, this process prevents the active ingredients from degradation and enhances the control and the drug release into specific sites.…”

Section: Introductionmentioning

confidence: 99%

Effect of secondary polymer on self‐precipitation of pH‐sensitive polymethylmethacrylate derivatives Eudragit E100 and Eudragit L100

Ofridam

Lebaz

Gagnière

et al. 2020

Polymers for Advanced Techs

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Interpolyelectrolyte complexes or polyplexes can be seen as interesting alternatives in the purpose of active ingredients encapsulation. Working on polymethylmethacrylate derivatives with special focus on controlled oral drug delivery, the influence of charged polyelectrolytes (polyacrylic acid, polyethylenimine, and aminodextran) and noncharged ones (polyvinyl alcohol, dextran 40, and Pluronic F68) has been investigated on the precipitation of two pH-sensitive Eudragit polymers, namely, L100 and E100. Moreover, the possibility of preparing polyplexes involving the two polymethylmethacrylate derivatives with different charged and noncharged secondary polyelectrolytes has been studied. The obtained dispersions have been characterized in terms of mean particle size, size distribution, zeta potential, and morphology. Direct precipitation of Eudragit L100 by medium acidification in a batch process and in the presence of polyethylenimine allowed the production of particles with a narrow size distribution. The mean size was around 200 nm. In this case, the zeta potential was found to be +45 mV at pH = 7 in 1mM aqueous NaCl solution, and the produced suspension was stable in time since no aggregation and sedimentation have been observed. A precipitation pH of 8.16 allows us to suggest the preparation of a polyplex based on Eudragit L100 and polyethylenimine. In contrary, polyvinyl alcohol has shown ability to induce an increase in particle mean size whereas other polyelectrolytes showed no significant effect. Moreover, it was observed that polyethylenimine and polyacrylic acid solutions were able to directly induce Eudragit E100 precipitation whereas amino-dextran and noncharged polyelectrolytes showed no effect on its precipitation and on particle size distribution. K E Y W O R D S dispersion, pH-sensitive polymers, polyplex, precipitation, self-precipitation 1 | INTRODUCTION Several polymers are nowadays used for the encapsulation of active molecules. This process covers a broad range of applications such as pharmaceutical, food, cosmetic, and textile industries. Among the commonly used coating materials, biodegradable polymers such as polysaccharides (starch and chitosan), proteins (gelatin and bovine serum albumin), polyesters (polylactide [PLA], polylactide-co-glycolide [PLGA], and polycaprolactone [PCL]), and polyether (polyethylene glycol [PEG]) are explored in the literature. 1 Moreover, nonbiodegradable stimuli-responsive polymers are largely studied especially the polymethylmethacrylate derivatives. 2

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Nanoprecipitation process: From encapsulation to drug delivery

Cited by 477 publications

References 89 publications

Synthesis and characterization of polylactide‐PAMAM “Janus‐type” linear‐dendritic hybrids

Synthesis and characterization of polylactide‐PAMAM “Janus‐type” linear‐dendritic hybrids

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

Effect of secondary polymer on self‐precipitation of pH‐sensitive polymethylmethacrylate derivatives Eudragit E100 and Eudragit L100

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