Nanoplatform based on GSH-responsive mesoporous silica nanoparticles for cancer therapy and mitochondrial targeted imaging

He, Huijuan; Song, Mengjia; Li, Haimin; Yang, Qingyuan; Xu, Zong‐Xiang; Chen, Xueqin; Sun, Zhengguang; Jiang, Bingbing; Li, Cao

doi:10.1007/s00604-021-04810-4

Cited by 32 publications

(26 citation statements)

References 33 publications

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“…For Mn, HCO 3 − is necessary for Mn to realize Fenton‐like reaction. [ 286 ] It is reported that Mn(IV) is unstable without a stabilizing coordinating ligand and can result in the formation of catalytically inactive MnO 2 . [ 399 ] HCO 3 − as a stabilizing ligand is important for enhancing the efficiency of Mn‐mediated CDT.…”

Section: Discussionmentioning

confidence: 99%

“…[ 283 ] Hence, MnO 2 nanostructures represent ideal platforms for realizing the combined use of chemotherapy and CDT. [ 282–286 ] For example, Wang et al. prepared platelet membrane (PLTM)‐coated bufalin‐loaded HMnO 2 NPs (termed PLTM‐HMnO 2 @Bu NPs) for MRI‐guided chemo‐chemodynamic therapy (Figure 7d).…”

Section: Applications Of Cdt In Anticancer and Antibacterial Therapiesmentioning

confidence: 99%

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Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Jia

Guo

2021

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Chemodynamic therapy (CDT), a novel cancer therapeutic strategy defined as the treatment using Fenton or Fenton‐like reaction to produce •OH in the tumor region, was first proposed by Bu, Shi, and co‐workers in 2016. Recently, with the rapid development of Fenton and Fenton‐like nanomaterials, CDT has attracted tremendous attention because of its unique advantages: 1) It is tumor‐selective with low side effects; 2) the CDT process does not depend on external field stimulation; 3) it can modulate the hypoxic and immunosuppressive tumor microenvironment; 4) the treatment cost of CDT is low. In addition to the Fe‐involved CDT strategies, the Fenton‐like reaction‐mediated CDT strategies have also been proposed, which are based on many other metal elements including copper, manganese, cobalt, titanium, vanadium, palladium, silver, molybdenum, ruthenium, tungsten, cerium, and zinc. Moreover, CDT has been combined with other therapies like chemotherapy, radiotherapy, phototherapy, sonodynamic therapy, and immunotherapy for achieving enhanced anticancer effects. Besides, there have also been studies that extend the application of CDT to the antibacterial field. This review introduces the latest advancements in the nanomaterials‐involved CDT from 2018 to the present and proposes the current limitations as well as future research directions in the related field.

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Section: Discussionmentioning

confidence: 99%

Section: Applications Of Cdt In Anticancer and Antibacterial Therapiesmentioning

confidence: 99%

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Jia

Guo

2021

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“…Mn 2+ could not only consume GSH but also display Fenton-like properties. [64][65][66] Based on this, Xiaoyuan Chen et al constructed MnO 2 -based mesoporous silica nanoparticles (MS@MnO 2 NP). 67 Once taken up by cancer cells, the MnO 2 shell was used to oxidize GSH to accumulate H 2 O 2 , which led to RDH, ultimately enhancing Mn 2+ -mediated CDT.…”

Section: Decreasing the Gsh Level Of Tumor Cells To Realize Rdh Via C...mentioning

confidence: 99%

Redox dyshomeostasis strategy for tumor therapy based on nanomaterials chemistry

et al. 2022

Chem. Sci.

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“…However, the effectiveness of traditional chemotherapy is limited by its poor selectivity, poor aqueous solubility, high systemic toxicity, and multidrug resistance [ 91 , 366 , 367 ]. MSNs have emerged as a potential drug delivery system that can both improve chemotherapy on its own [ 368 , 369 , 370 ] as well as in combination with other cancer therapies [ 90 , 371 , 372 ]. One of the major challenges of chemotherapy is the multidrug resistance (MDR) that is commonly attributed to the overexpression of the transmembrane efflux pump P-glycoprotein (P-gp) in cancer cells.…”

Section: Update On Msn Applications In Nanomedicinesmentioning

confidence: 99%

An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine

et al. 2021

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The efficient and safe delivery of therapeutic drugs, proteins, and nucleic acids are essential for meaningful therapeutic benefits. The field of nanomedicine shows promising implications in the development of therapeutics by delivering diagnostic and therapeutic compounds. Nanomedicine development has led to significant advances in the design and engineering of nanocarrier systems with supra-molecular structures. Smart mesoporous silica nanoparticles (MSNs), with excellent biocompatibility, tunable physicochemical properties, and site-specific functionalization, offer efficient and high loading capacity as well as robust and targeted delivery of a variety of payloads in a controlled fashion. Such unique nanocarriers should have great potential for challenging biomedical applications, such as tissue engineering, bioimaging techniques, stem cell research, and cancer therapies. However, in vivo applications of these nanocarriers should be further validated before clinical translation. To this end, this review begins with a brief introduction of MSNs properties, targeted drug delivery, and controlled release with a particular emphasis on their most recent diagnostic and therapeutic applications.

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Nanoplatform based on GSH-responsive mesoporous silica nanoparticles for cancer therapy and mitochondrial targeted imaging

Cited by 32 publications

References 33 publications

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Chemodynamic Therapy via Fenton and Fenton‐Like Nanomaterials: Strategies and Recent Advances

Redox dyshomeostasis strategy for tumor therapy based on nanomaterials chemistry

An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine

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