Nanophotosensitizer-engineered Salmonella bacteria with hypoxia targeting and photothermal-assisted mutual bioaccumulation for solid tumor therapy

Chen, Fuming; Zang, Zhongsheng; Chen, Ze; Cui, Liao; Chang, Zhiguang; Ma, Aiqing; Yin, Ting; Liang, Ruijing; Han, Yutong; Wu, Zhihao; Zheng, Mingbin; Liu, Chenli; Cai, Lintao

doi:10.1016/j.biomaterials.2019.119226

Cited by 132 publications

(133 citation statements)

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“…Numerous nanoparticles and functional molecules have been attached to fabricate multimodal bacterial based bioagents for treatment. [23][24][25][26][27][28][29][30] Recently, we have coated bacteria with biological membranes to protect them from environmental attacks. [31,32] For example, a probiotic bacterium coated with erythrocyte membranes exhibits decreased elimination by macrophages.…”

Section: Doi: 101002/adma202002406mentioning

confidence: 99%

On‐Demand Bacterial Reactivation by Restraining within a Triggerable Nanocoating

et al. 2020

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Bacteria have been widely exploited as bioagents for applications in diagnosis and treatment, benefitting from their living characteristics including colonization, rapid proliferation, and facile genetic manipulation. As such, bacteria being tailored to perform precisely in the right place at the right time to avoid potential side effects would be of great importance but has proven to be difficult. Here, a strategy of on‐demand bacterial reactivation is described by individually restraining within a triggerable nanocoating. Upon reaching at a location of interest, nanocoatings can be triggered to dissolution in situ and subsequently decoat the bacteria which are able to recover their bioactivities as needed. It is demonstrated that gut microbiota coated with an enteric nanocoating can respond to gastrointestinal environments and reactivate in the intestine by a pH‐triggered decoating. In virtue of this unique, coated bacteria remain inactive following oral administration to exempt acidic insults, while revive to restore therapeutic effects after gastric emptying. Consequently, improved oral availability and treatment efficacy are achieved in two mouse models of intestinal infection. Bacteria restrained by a triggerable nanocoating represent a smart therapeutic that can take effect when necessary. On‐demand bacterial reactivation suggests a robust platform for the development of precision bacterial‐mediated bioagents.

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Section: Doi: 101002/adma202002406mentioning

confidence: 99%

On‐Demand Bacterial Reactivation by Restraining within a Triggerable Nanocoating

et al. 2020

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“…Photothermal Reproduced with permission. [139] Copyright 2019, Elsevier. effect (YB1-INPs (+)) initiated tumor lysis and bacteria-attracting nutrients were generated at the tumor site, further enhancing tumor nanoparticle accumulation as shown in Figure 6b,c.…”

Section: Other Imaging Strategiesmentioning

confidence: 99%

Nano versus Molecular: Optical Imaging Approaches to Detect and Monitor Tumor Hypoxia

Cheng

Zheng

2020

Adv Healthcare Materials

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Hypoxia is a ubiquitous feature of solid tumors, which plays a key role in tumor angiogenesis and resistance development. Conventional hypoxia detection methods lack continuous functional detection and are generally less suitable for dynamic hypoxia measurement. Optical sensors hereby provide a unique opportunity to noninvasively image hypoxia with high spatiotemporal resolution and enable real‐time detection. Therefore, these approaches can provide a valuable tool for personalized treatment planning against this hallmark of aggressive cancers. Many small optical molecular probes can enable analyte triggered response and their photophysical properties can also be fine‐tuned through structural modification. On the other hand, optical nanoprobes can acquire unique intrinsic optical properties through nanoconfinement as well as enable simultaneous multimodal imaging and drug delivery. Furthermore, nanoprobes provide biological advantages such as improving bioavailability and systemic delivery of the sensor to enhance bioavailability. This review provides a comprehensive overview of the physical, chemical, and biological analytes for cancer hypoxia detection and focuses on discussing the latest nano‐ and molecular developments in various optical imaging approaches (fluorescence, phosphorescence, and photoacoustic) in vivo. Finally, this review concludes with a perspective toward the potentials of these optical imaging approaches in hypoxia detection and the challenges with molecular and nanotechnology design strategies.

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“…† Compared with CyOH, CyO-Ag had a lower DE ST and thus could increase the ISC rate and improve the yield of 1 O 2 . [16][17][18] The proposed mechanism is described in Fig. 3.…”

Section: O 2 Production and Cytotoxicitymentioning

confidence: 99%

“…14 To overcome these aforementioned disadvantages, new generation nanophotosensitizers were synthesized using a NIR organic dye doped nanomaterial for improved uorescence imaging and efficient treatment of tumors. [15][16][17][18] An excellent nanophotosensitizer for high efficiency PDT should have at least three features: NIR light emission, high singlet-to-triplet intersystem crossing (ISC) efficiency, and tumor targeting. Decreasing the DE ST (energy gap) of nanocomposites can improve the singlet-to-triplet ISC rate, leading to an increase in 1 O 2 yield.…”

Section: Introductionmentioning

confidence: 99%

A near infrared dye-coated silver nanoparticle/carbon dot nanocomposite for targeted tumor imaging and enhanced photodynamic therapy

et al. 2020

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Nanophotosensitizer-engineered Salmonella bacteria with hypoxia targeting and photothermal-assisted mutual bioaccumulation for solid tumor therapy

Cited by 132 publications

References 46 publications

On‐Demand Bacterial Reactivation by Restraining within a Triggerable Nanocoating

On‐Demand Bacterial Reactivation by Restraining within a Triggerable Nanocoating

Nano versus Molecular: Optical Imaging Approaches to Detect and Monitor Tumor Hypoxia

A near infrared dye-coated silver nanoparticle/carbon dot nanocomposite for targeted tumor imaging and enhanced photodynamic therapy

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