Nanophotosensitive Drugs for Light-Based Cancer Therapy: What Does the Future Hold?

Tang, Rui; Habimana-Griffin, LeMoyne; Lane, Daniel D.; Egbulefu, Christopher; Achilefu, Samuel

doi:10.2217/nnm-2017-0077

Cited by 14 publications

(3 citation statements)

References 21 publications

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“…These highly reactive species result in a shift of redox balance and trigger the activation of transcription factors implicated in the initiation of cell death signalling via apoptosis and/or necrosis. The efficacy of PDT mainly relies on the yield of singlet oxygen and other ROS production by a PS and this yield depends on the nature of PS involved [9,10] .…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility and Toxicity of Graphene Quantum Dots for Potential Application in Photodynamic Therapy

Tabish

Scotton

Ferguson

et al. 2018

Nanomedicine (Lond.)

165

113

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Section: Introductionmentioning

confidence: 99%

Biocompatibility and Toxicity of Graphene Quantum Dots for Potential Application in Photodynamic Therapy

Tabish

Scotton

Ferguson

et al. 2018

Nanomedicine (Lond.)

165

113

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“…We recently reported the use of low-dose radionuclides to potentiate the therapeutic effects of ROS-generating TiO 2 NPs. − We demonstrated that the approach is capable of inhibiting tumor growth with minimal side effects via sequential administration of the NPs first, followed by radionuclides. Among other mechanisms, we found that TiO 2 NPs can harvest the UV light from Cerenkov radiation of fluorine-18 fluorodeoxyglucose ( 18 FDG) to stimulate reactive oxygen species (ROS) generation.…”

mentioning

confidence: 99%

Osteotropic Radiolabeled Nanophotosensitizer for Imaging and Treating Multiple Myeloma

et al. 2020

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Rapid liver and spleen opsonization of systemically administered nanoparticles (NPs) for in vivo applications remains the Achilles’ heel of nanomedicine, allowing only a small fraction of the materials to reach the intended target tissue. Although focusing on diseases that reside in the natural disposal organs for nanoparticles is a viable option, it limits the plurality of lesions that could benefit from nanomedical interventions. Here we designed a theranostic nanoplatform consisting of reactive oxygen (ROS)-generating titanium dioxide (TiO2) NPs, coated with a tumor-targeting agent, transferrin (Tf), and radiolabeled with a radionuclide (89Zr) for targeting bone marrow, imaging the distribution of the NPs, and stimulating ROS generation for cell killing. Radiolabeling of TiO2 NPs with 89Zr afforded thermodynamically and kinetically stable chelate-free 89Zr-TiO2-Tf NPs without altering the NP morphology. Treatment of multiple myeloma (MM) cells, a disease of plasma cells originating in the bone marrow, with 89Zr-TiO2-Tf generated cytotoxic ROS to induce cancer cell killing via the apoptosis pathway. Positron emission tomography/X-ray computed tomography (PET/CT) imaging and tissue biodistribution studies revealed that in vivo administration of 89Zr-TiO2-Tf in mice leveraged the osteotropic effect of 89Zr to selectively localize about 70% of the injected radioactivity in mouse bone tissue. A combination of small-animal PET/CT imaging of NP distribution and bioluminescence imaging of cancer progression showed that a single-dose 89Zr-TiO2-Tf treatment in a disseminated MM mouse model completely inhibited cancer growth at euthanasia of untreated mice and at least doubled the survival of treated mice. Treatment of the mice with cold Zr-TiO2-Tf, 89Zr-oxalate, or 89Zr-Tf had no therapeutic benefit compared to untreated controls. This study reveals an effective radionuclide sensitizing nanophototherapy paradigm for the treatment of MM and possibly other bone-associated malignancies.

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“…Our study sets the stage for imaging with all β-emitting radionuclides, exploiting the advantages of an enhanced signal emanating from the NP compared to CL alone. Using radionuclides with radiosensitizing agents for photodynamic therapy is increasingly investigated, 44 – 46 and a greater understanding of how NPs can increase photon density for PDT should aid progress. Additionally, the heretofore unappreciated characteristic X-rays resulting from these interactions yields a new imaging modality in SPECT.…”

Section: Discussionmentioning

confidence: 99%

Nanoparticles as multimodal photon transducers of ionizing radiation

et al. 2018

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In biomedical imaging, nanoparticles combined with radionuclides that generate Cerenkov luminescence are used in diagnostic imaging, photon-induced therapies, and as activatable probes. In these applications, the nanoparticle is often viewed as a carrier inert to ionizing radiation from the radionuclide. However, certain phenomena such as enhanced nanoparticle luminescence and generation of reactive oxygen species cannot be explained by only Cerenkov luminescence interactions with nanoparticles. Herein, we report methods to examine the mechanisms of nanoparticle excitation by radionuclides, including interactions with Cerenkov luminescence, β particles, and γ radiation. We demonstrate that β scintillation contributes appreciably to excitation and reactivity in certain nanoparticle systems and that excitation of nanoparticles composed of large atomic number atoms by radionuclides generates X-rays, enabling multiplexed imaging through single photon emission computed tomography. These findings demonstrate practical optical imaging and therapy using radionuclides with emission energies below the Cerenkov threshold, thereby expanding the list of applicable radionuclides.

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Nanophotosensitive Drugs for Light-Based Cancer Therapy: What Does the Future Hold?

Cited by 14 publications

References 21 publications

Biocompatibility and Toxicity of Graphene Quantum Dots for Potential Application in Photodynamic Therapy

Biocompatibility and Toxicity of Graphene Quantum Dots for Potential Application in Photodynamic Therapy

Osteotropic Radiolabeled Nanophotosensitizer for Imaging and Treating Multiple Myeloma

Nanoparticles as multimodal photon transducers of ionizing radiation

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