Nanoparticles promote in vivo breast cancer cell intravasation and extravasation by inducing endothelial leakiness

Peng, Fei; Setyawati, Magdiel Inggrid; Tee, Jie Kai; Ding, Xiaoyun; Wang, Jinping; Nga, Min En; Ho, Han Kiat; Leong, David Tai

doi:10.1038/s41565-018-0356-z

Cited by 396 publications

(268 citation statements)

References 34 publications

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“…Leong's group [15][16][17][18] demonstrated the toxicity of inorganic nanoparticles to vascular endothelial (VE)-cadherin, a critical adherens junction protein which participates in the integrity of endothelial barrier/permeability, in the cytotoxicity of inorganic nanoparticles.…”

Section: (Continued From Previous Page)mentioning

confidence: 99%

Silica nanomaterials induce organ injuries by Ca2+-ROS-initiated disruption of the endothelial barrier and triggering intravascular coagulation

Wang

Zhao

et al. 2020

Part Fibre Toxicol

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Background: The growing use of silica nanoparticles (SiNPs) in many fields raises human toxicity concerns. We studied the toxicity of SiNP-20 (particle diameter 20 nm) and SiNP-100 (100 nm) and the underlying mechanisms with a focus on the endothelium both in vitro and in vivo. Methods:The study was conducted in cultured human umbilical vein endothelial cells (HUVECs) and adult female Balb/c mice using several techniques.Results: In vitro, both SiNP-20 and SiNP-100 decreased the viability and damaged the plasma membrane of cultured HUVECs. The nanoparticles also inhibited HUVECs migration and tube formation in a concentrationdependent manner. Both SiNPs induced significant calcium mobilization and generation of reactive oxygen species (ROS), increased the phosphorylation of vascular endothelial (VE)-cadherin at the site of tyrosine 731 residue (pY731-VEC), decreased the expression of VE-cadherin expression, disrupted the junctional VE-cadherin continuity and induced F-actin re-assembly in HUVECs. The injuries were reversed by blocking Ca 2+ release activated Ca 2+ (CRAC) channels with YM58483 or by eliminating ROS with N-acetyl cysteine (NAC). In vivo, both SiNP-20 and SiNP-100 (i.v.) induced multiple organ injuries of Balb/c mice in a dose (range 7-35 mg/kg), particle size, and exposure time (4-72 h)-dependent manner. Heart injuries included coronary endothelial damage, erythrocyte adhesion to coronary intima and coronary coagulation. Abdominal aorta injury exhibited intimal neoplasm formation. Lung injuries were smaller pulmonary vein coagulation, bronchiolar epithelial edema and lumen oozing and narrowing. Liver injuries included multifocal necrosis and smaller hepatic vein congestion and coagulation. Kidney injuries involved glomerular congestion and swelling. Macrophage infiltration occurred in all of the observed organ tissues after SiNPs exposure. SiNPs also decreased VE-cadherin expression and altered VE-cadherin spatial distribution in multiple organ tissues in vivo. The largest SiNP (SiNP-100) and longest exposure time exerted the greatest toxicity both in vitro and in vivo.

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Section: (Continued From Previous Page)mentioning

confidence: 99%

Silica nanomaterials induce organ injuries by Ca2+-ROS-initiated disruption of the endothelial barrier and triggering intravascular coagulation

Wang

Zhao

et al. 2020

Part Fibre Toxicol

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“…Advancement of nanotechnology has extensively expedited the emergence of novel magnetic nanostructures, such as magnetic nanowires (MNWs), in various research areas, including medical treatment [1][2][3][4][5], environmental science [6,7], and quantum devices [8][9][10][11][12]. These magnetic nanostructures have opened numerous opportunities for scientists in different disciplines such as nanomedicine, molecular biology [13][14][15][16], applied physics, and nanostructured materials [17][18][19][20][21][22]. In all of these applications, it is crucial to know the characteristics of the magnetic nanostructures, which may inhibit or enhance their use depending on the application.…”

Section: Introductionmentioning

confidence: 99%

Beyond the qualitative description of complex magnetic nanoparticle arrays using FORC measurement

Kouhpanji

Stadler

2020

Nano Ex.

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First-order reversal curve (FORC) measurements are broadly used for the characterization of complex magnetic nanostructures, but they can be inconclusive when quantifying the amount of different magnetic phases present in a sample. In this paper, we first establish a framework for extracting quantitative parameters from FORC measurements conducted on samples composed of a single type of magnetic nanostructure to interpret their magnetic properties. We then generalize our framework for the quantitative characterization of samples that are composed of 2-4 types of FeCo magnetic nanowires to determine the most reliable and reproducible parameters for a detailed analysis of samples. Finally, we conclude that the parameter with the best quantification potential, backfield remanence coercivity, does not require the full FORC measurement. Our approach provides an insightful path for fast, quantitative analysis of complex magnetic nanostructures, especially determination of the ratios of magnetic subcomponents present in multi-phase samples.

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“…[1][2][3][4][5] Compared with the primary tumors, metastatic tumors respond poorly to current treatments such as radiotherapy, chemotherapy and targeted therapy that are more potent against proliferating cells, [6][7][8][9][10] partially because those cancer cells are dormant through most stages of invasion-metastatic cascade. [1][2][3][4][5] Compared with the primary tumors, metastatic tumors respond poorly to current treatments such as radiotherapy, chemotherapy and targeted therapy that are more potent against proliferating cells, [6][7][8][9][10] partially because those cancer cells are dormant through most stages of invasion-metastatic cascade.…”

Section: Nanomedicine-based Immunotherapy For the Treatment Of Cancermentioning

confidence: 99%

Nanomedicine‐Based Immunotherapy for the Treatment of Cancer Metastasis

et al. 2019

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Metastasis is the leading cause of cancer‐associated death, with poor prognosis even after extensive treatment. The dormancy of metastatic cancer cells during dissemination or after colony formation is one major reason for treatment failure, as most drugs target cells of active proliferation. Immunotherapy has shown great potential in cancer therapy because the activity of effector cells is less affected by the metabolic status of cancer cells. In addition, metastatic cells out of immunosuppressive tumor microenvironment (TME) are more susceptible to immune clearance, although these cells can achieve immune surveillance evasion via strategies such as platelet and macrophage recruitment. Since nanomaterials themselves or their carried drugs have the capability to modulate the immune system, a great amount of focus has been placed on nanomedicine strategies that leverage immune cells participating the metastatic cascade. These nanomedicines successfully inhibit the tumor metastasis and prolong the survival of model animals. Immune cells that are involved in the metastasis cascade are first summarized and then recent and inspiring strategies and nanomaterials in this growing field are highlighted.

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Nanoparticles promote in vivo breast cancer cell intravasation and extravasation by inducing endothelial leakiness

Cited by 396 publications

References 34 publications

Silica nanomaterials induce organ injuries by Ca2+-ROS-initiated disruption of the endothelial barrier and triggering intravascular coagulation

Silica nanomaterials induce organ injuries by Ca2+-ROS-initiated disruption of the endothelial barrier and triggering intravascular coagulation

Beyond the qualitative description of complex magnetic nanoparticle arrays using FORC measurement

Nanomedicine‐Based Immunotherapy for the Treatment of Cancer Metastasis

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