Nanoparticles of Punicalagin Synthesized from Pomegranate (Punica Granatum L.) with Enhanced Efficacy Against Human Hepatic Carcinoma Cells

Mehra, Akansha; Chauhan, Sonal; Jain, V. K.; Nagpal, Suman

doi:10.1007/s10876-021-01979-9

Cited by 10 publications

(4 citation statements)

References 24 publications

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“…In another study, the peel waste of P. granatum was employed for the biosynthesis of AgNPs and the antibacterial potential was explored against both Gram-negative and Gram-positive bacteria along with evaluation of its cytotoxicity against a colon cancer cell line, RKO [ 20 ]. A further study reported the use of Punicalagin, found in P. granatum husk, for the synthesis of AgNPs and exploration of its antioxidant, antibacterial and anticancer potential against HepG2 cancer cells [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Antibacterial and Antibiofilm Efficacy of Silver Nanoparticles Biosynthesized Using Punica granatum Leaves

Singhal¹,

Chatterjee²,

Kumar

et al. 2021

Molecules

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The current research work illustrates an economical and rapid approach towards the biogenic synthesis of silver nanoparticles using aqueous Punica granatum leaves extract (PGL-AgNPs). The optimization of major parameters involved in the biosynthesis process was done using Box-Behnken Design (BBD). The effects of different independent variables (parameters), namely concentration of AgNO3, temperature and ratio of extract to AgNO3, on response viz. particle size and polydispersity index were analyzed. As a result of experiment designing, 17 reactions were generated, which were further validated experimentally. The statistical and mathematical approaches were employed on these reactions in order to interpret the relationship between the factors and responses. The biosynthesized nanoparticles were initially characterized by UV-vis spectrophotometry followed by physicochemical analysis for determination of particle size, polydispersity index and zeta potential via dynamic light scattering (DLS), SEM and EDX studies. Moreover, the determination of the functional group present in the leaves extract and PGL-AgNPs was done by FTIR. Antibacterial and antibiofilm efficacies of PGL-AgNPs against Gram-positive and Gram-negative bacteria were further determined. The physicochemical studies suggested that PGL-AgNPs were round in shape and of ~37.5 nm in size with uniform distribution. Our studies suggested that PGL-AgNPs exhibit potent antibacterial and antibiofilm properties.

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Section: Introductionmentioning

confidence: 99%

Exploring the Antibacterial and Antibiofilm Efficacy of Silver Nanoparticles Biosynthesized Using Punica granatum Leaves

Singhal¹,

Chatterjee²,

Kumar

et al. 2021

Molecules

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“…Anthocyanin delphinin, a natural phytotoxin, also causes apoptosis and activates caspase-3 and c-Jun [148]. Last but not least, nanoparticles loaded with pomegranate-derived-punicalagin (100 µg/mL) exert anticancer activity against HepG2 cancer cells inducing a 44% reduction in their viability after treatment [149].…”

Section: Other Types Of Cancermentioning

confidence: 99%

The Therapeutic Alliance between Pomegranate and Health Emphasizing on Anticancer Properties

et al. 2023

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Pomegranate is a fruit bearing-plant that is well known for its medicinal properties. Pomegranate is a good source of phenolic acids, tannins, and flavonoids. Pomegranate juice and by-products have attracted the scientific interest due to their potential health benefits. Currently, the medical community has showed great interest in exploiting pomegranate potential as a protective agent against several human diseases including cancer. This is demonstrated by the fact that there are more than 800 reports in the literature reporting pomegranate’s anticancer properties. This review is an update on the research outcomes of pomegranate’s potential against different types of human diseases, emphasizing on cancer. In addition, perspectives of potential applications of pomegranate, as a natural additive aiming to improve the quality of animal products, are discussed.

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“…Recent studies on pomegranate have focused on its antibacterial [Gosset-Erard et al, 2021;Mehra et al, 2021], anticarcinogenic [Moga et al, 2021] antidiabetic [Bashkin et al, 2021], anti-in ammatory [El Bohi et al, 2021], antimicrobial [Elsha e, et al, 2021], antioxidant [Khemakhem et al, 2021], antirheumatic [Malek et al, 2021] and antiviral [Salles et al, 2021] properties. The purpose of this study was to collect scienti c data on the phytochemical content and antitrypanosomal potential of three different pomegranate leaf extracts.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Screening for Antitrypanosomal Potentials of Punica granatum L. Leaves Crude Extracts

Fathuddin

Inabo

2022

Preprint

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Purpose: Punica granatum (P. granatum) L. leaves were examined for potential antitrypanosomal properties. These leaves were acquired and identified at Ahmadu Bello University (A.B.U.) Herbarium Unit in Zaria. Following drying, the following solvents—chloroform, ethyl acetate, and ethanol—were used for exhaustive Soxhlet extraction. The crude extracts phytochemical analysis and in vitro antitrypanosomal capability were performed on Trypanosoma brucei brucei (T. b. brucei). Research Method: The National Research Institute for Chemical Technology (NARICT), Basawa, Zaria, obtained the organism T. b. brucei. The wet and thick blood film method and the rapid matching method were used to examine the antitrypanosomal activity under 400x magnification. In 96-round-bottom well microtiter plates, the in vitro trypanocidal activity was evaluated in duplicate. Findings: The antitrypanosomal activity of the ethanol and ethyl acetate extracts ranged from 6.25 to 400 mg/ml. Red blood cells (RBCs) were destroyed at all concentrations between 200 and 400 mg/ml, while between 6.25 and 100 mg/ml, the RBCs were still intact. As concentrations dropped, the parasite's motility rose. The parasite's motility entirely stopped after 60 minutes, whereas it continued for an additional 80 minutes in the negative control. A standard medicine that was made per the manufacturer's instructions and used as the positive control cleared everything in less than a minute. Original/Value: This research may help in the development of novel antitrypanosomal medications from P. granatum L. As a result, despite lysing the RBC and having no effect on the parasite, the chloroform extract did not kill it. At a minimum concentration of 6.25 mg/ml, the P. granatum L. ethyl acetate and ethanol extract have the potential to operate as antitrypanosomal agents.

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Nanoparticles of Punicalagin Synthesized from Pomegranate (Punica Granatum L.) with Enhanced Efficacy Against Human Hepatic Carcinoma Cells

Cited by 10 publications

References 24 publications

Exploring the Antibacterial and Antibiofilm Efficacy of Silver Nanoparticles Biosynthesized Using Punica granatum Leaves

Exploring the Antibacterial and Antibiofilm Efficacy of Silver Nanoparticles Biosynthesized Using Punica granatum Leaves

The Therapeutic Alliance between Pomegranate and Health Emphasizing on Anticancer Properties

In Vitro Screening for Antitrypanosomal Potentials of Punica granatum L. Leaves Crude Extracts

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