Nanoparticles of Polyethylene Sebacate: A New Biodegradable Polymer

Abstract

Abstract. The present study demonstrates feasibility of preparation of nanoparticles using a novel polymer, polyethylene sebacate (PES), and its application in the design of drug-loaded nanocarriers. Silymarin was selected as a model hydrophobic drug for the present study. Two methods of preparation, viz., nanoprecipitation and emulsion solvent diffusion, were evaluated for preparation of nanoparticles. Effect of surfactants polyvinyl alcohol (PVA), lutrol F 68, and Tween 80 on the preparation of blank and silymarin-loaded PES nanoparticles was evaluated. Nanoprecipitation resulted in the formation of nanoparticles with all the surfactants (<450 nm). Increase in surfactant concentration resulted in decrease in entrapment efficiency and particle size except with PVA. The type and concentration of surfactant was critical to achieve low size and adequate drug entrapment. While increase in concentration of PES resulted in larger nanoparticles, inclusion of acetone in the organic phase resulted in particles of smaller size. In case of emulsion solvent diffusion, nanoparticles were obtained only with lutrol F 68 as surfactant and high surfactant concentration. The study revealed nanoprecipitation as a more versatile method for preparation of PES nanoparticles. Scanning electron microscopy studies revealed spherical shape of nanoparticles. Freeze-dried nanoparticles exhibited ease of redispersion, with a marginal increase in size. Differential scanning calorimetry and X-ray diffraction analysis revealed amorphous nature of the drug. The study demonstrates successful design of PES nanoparticles as drug carriers.

Influence of process and formulation parameters on the formation of submicron particles by solvent displacement and emulsification–diffusion methods

“…However, wide ranges are also reported for these parameters in both solvent displacement [15,41,42,44,51,72,77] and emulsification-diffusion studies [22,86,93]. Unfortunately, there are no works have been published providing comparisons of the two methods when the same active substance is used.…”

Encapsulation characteristics of protein hydrolysate extracted from Ziziphus jujube seed

“…The supernatant obtained after centrifugation was suitably diluted and analysed for free protein by Bradford method at 595 nm [19,20] . The per cent entrapment efficiency was calculated as follows:…”

Catalytic Reduction of p-Nitrophenol Using Chitosan Stabilized Copper Nanoparticles

“…In this case, the higher viscosity of the polymer solution may have played a role in influencing the particle size. As it is harder for the particles to diffuse and penetrate into the polymer chains region, the Cu particles tend to grow larger due to greater metal-metal interaction [33]. The possible interaction between copper nanoparticles and chitosan was studied using FTIR.…”