Nanoparticles in Polyelectrolyte Multilayer Layer-by-Layer (LbL) Films and Capsules—Key Enabling Components of Hybrid Coatings

Lengert, Ekaterina; Kol'tsov, S. I.; Li, Jie; Ermakov, А. V.; Parakhonskiy, Bogdan; Skorb, Ekaterina V.; Skirtach, André G.

doi:10.3390/coatings10111131

Cited by 48 publications

(24 citation statements)

References 243 publications

(284 reference statements)

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“…[ 60,67 ] Also, there are different approaches for enhancing cell adhesion properties, including hybrid materials, [ 28,29 ] where inorganic components (often nanoparticles) directly stimulate the cell growth by incorporation of such biomolecules as alkaline phosphatase. [ 68,69 ] Nanoparticles have been recognized for affecting the polymeric structures, [ 70,71 ] so controlled nanoparticle adsorption [ 72 ] at biointerfaces has been shown, on the one hand, to serve as activation centers, [ 73 ] while, on the other hand, to promote cell adhesion. [ 74 ] Considering that the incorporation of either proteins or peptide sequences renders cell‐adhesive hydrogel production more complex and the final systems more expensive, we propose thermally annealed gellan gum (T‐A GG) hydrogels with fibrillar nanoarchitecture and tunable cell‐adhesive character by a simple and cost‐effective method.…”

Section: Introductionmentioning

confidence: 99%

Nanofibrillar Hydrogels by Temperature Driven Self‐Assembly: New Structures for Cell Growth and Their Biological and Medical Implications

Abalymov

Santos

Meeren

et al. 2021

Adv Materials Inter

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Nanofibrillar structures are of importance in biomedicine, including lung, cardiovascular, liver, skin, neuroscience research, and tissue engineering. Developing advanced materials and interfaces should contribute to uncovering the mechanisms of diseases aiming to find cure. The similarity between the extracellular matrix (ECM) of soft tissue and hydrogels, characterized by a high water‐content viscoelastic polymeric fiber, has stimulated the development of hydrogels for biomedical applications. However, most hydrogels have a meshy structure resulting in poor cell adhesion properties. Here, fabrication of gellan gum (GG) hydrogels arranged by thermally driven self‐assembly into a network of nanofibers is reported. Mechanical properties of such nanofibrillar hydrogels are analyzed on micro‐ and macroscales. As a result, and in sharp contrast to commonly produced meshy GG hydrogels, the nanofiber‐based hydrogels facilitate the adherence and lead to proliferation of cells. This is assigned to microstructural rearrangements characterized by a changing density and pore size decrease, accompanied with a lower water content. Cell growth on such nanofibrillar structures is investigated for osteoblasts, which are chosen as a model system. The developed nanofibrous interfaces in this study are envisioned to be applicable for growing various types of cells and they should contribute to better understanding cell interactions with ECM.

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Section: Introductionmentioning

confidence: 99%

Nanofibrillar Hydrogels by Temperature Driven Self‐Assembly: New Structures for Cell Growth and Their Biological and Medical Implications

Abalymov

Santos

Meeren

et al. 2021

Adv Materials Inter

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“…[ 24 ] However, such coatings can change the response signal. [ 25,26 ] The most revealing example is the change in the photoluminescence of quantum dots covered with a polyelectrolyte shell. Thus, the study of the phenomenon of charge transfer in polyelectrolyte layers is an important task.…”

Section: Layer‐by‐layer Approachmentioning

confidence: 99%

Recent Progress of Layer‐by‐layer Assembly, Free‐Standing Film and Hydrogel Based on Polyelectrolytes

Ivanov

Pershina

Nikolaev

et al. 2021

Macromolecular Bioscience

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Nowadays, polyelectrolytes play an essential role in the development of new materials. Their use allows creating new properties of materials and surfaces and vary them in a wide range. Basically, modern methods are divided into three areas—the process of layer‐by‐layer deposition, free‐standing films, and hydrogels based on polyelectrolytes. Layer‐by‐layer assembly of polyelectrolytes on various surfaces is a powerful technique. It allows giving surfaces new properties, for example, protect them from corrosion. Free‐standing films are essential tools for the design of membranes and sensors. Hydrogels based on polyelectrolytes have recently shown their applicability in electrical and materials science. The creation of new materials and components with controlled properties can be achieved using polyelectrolytes. This review focuses on new technologies that have been developed with polyelectrolytes over the last five years.

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“…Despite having slight similarity to conventional methods, advanced PEMs enable further diversity in application, presenting a range of trajectories unmatchable with conventional methods to fabricate multilayers for future designs. Some examples include creating film patterning, which presents difficulties in assembling at nanoscales, expansion in biological assemblies (particularly on soft, biocompatible substrates) and control of LBL assembly at both smaller and larger scales than the conventional method [ 88 , 89 ].…”

Section: Fabrication Of Different Types Of Pe Gelsmentioning

confidence: 99%

Polyelectrolyte Gels: Fundamentals, Fabrication and Applications

Wanasingha¹,

Dorishetty²,

Dutta³

et al. 2021

Gels

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Polyelectrolyte gels are an important class of polymer gels and a versatile platform with charged polymer networks with ionisable groups. They have drawn significant recent attention as a class of smart material and have demonstrated potential for a variety of applications. This review begins with the fundamentals of polyelectrolyte gels, which encompass various classifications (i.e., origin, charge, shape) and crucial aspects (ionic conductivity and stimuli responsiveness). It further centralises recent developments of polyelectrolyte gels, emphasising their synthesis, structure–property relationships and responsive properties. Sequentially, this review demonstrates how polyelectrolyte gels’ flourishing properties create attractiveness to a range of applications including tissue engineering, drug delivery, actuators and bioelectronics. Finally, the review outlines the indisputable appeal, further improvements and emerging trends in polyelectrolyte gels.

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Nanoparticles in Polyelectrolyte Multilayer Layer-by-Layer (LbL) Films and Capsules—Key Enabling Components of Hybrid Coatings

Cited by 48 publications

References 243 publications

Nanofibrillar Hydrogels by Temperature Driven Self‐Assembly: New Structures for Cell Growth and Their Biological and Medical Implications

Nanofibrillar Hydrogels by Temperature Driven Self‐Assembly: New Structures for Cell Growth and Their Biological and Medical Implications

Recent Progress of Layer‐by‐layer Assembly, Free‐Standing Film and Hydrogel Based on Polyelectrolytes

Polyelectrolyte Gels: Fundamentals, Fabrication and Applications

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