Nanoparticles in clinical trials of COVID-19: An update

Abu-Izneid, Tareq; Khalil, Anees Ahmed; Hafeez, Nabia; Olatunde, Ahmed; Rahman, Md. Mominur; Semwal, Prabhakar; Al-Awthan, Yahya S.; Bahattab, Omar; Khan, Ishaq N.; Khan, Minhaj Ahmad; Sharma, Rohit

doi:10.1016/j.ijsu.2022.106818

Cited by 28 publications

(28 citation statements)

References 112 publications

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“…Vaccine designates a potent strategy for reducing COVID-19 morbidity ( 13 , 14 ). Nanoparticle-based SARS-CoV-2 vaccines, such as inactivated, non-replicating viral vector, and mRNA vaccines, have already been applied clinically worldwide ( 12 , 15 , 16 ). These COVID-19 vaccines can induce both SARS-CoV-2 specific CD4+ and CD8+ T-cell responses and neutralizing antibody production ( 15 , 17 – 19 ).…”

Section: Introductionmentioning

confidence: 99%

The correlation between serum 25-hydroxy-vitamin D levels and anti-SARS-CoV-2 S-RBD IgG and neutralizing antibody levels among cancer patients receiving COVID-19 vaccines

Rachman

Iriani²,

Priantono³

et al. 2022

Front. Nutr.

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IntroductionDuring the coronavirus disease 2019 (COVID-19) pandemic, vitamin D has been established as an immune-modulator that reduces pro-inflammatory damage which effectively diminish the severity of COVID-19. Vitamin D also has a significant effect against influenza and dengue and increase the seroconversion following influenza vaccination. To date, the role of vitamin D in optimizing the efficacy of COVID-19 vaccines remains unclear. This study aimed to analyze the correlation between serum 25-hydroxy-cholecalciferol or 25(OH)D levels and anti-SARS-CoV-2 S-RBD IgG and neutralizing antibody levels among cancer patients.MethodologyA multicenter cross-sectional study was conducted among solid and hematologic cancer patients who were vaccinated with two doses of the same types of COVID-19 vaccines (either mRNA, non-replicating viral vector, or inactivated) within 6 months.ResultThe median serum 25(OH)D level in 119 cancer patients was 36.36 [IQR = 30.30] ng/mL. The seropositivity of S-RBD IgG and NAb reached 93.3 and 94.1%, respectively. The S-RBD IgG level was significantly higher in the sufficient group (median = 414.07 [1,441.83] AU/mL) than in the deficient group (median = 91.56 [652.00] AU/mL) (p-value = 0.049). Among non-chemotherapy subjects, the anti-SARS-CoV-2 S-RBD IgG levels had a significant positive correlation with 25(OH)D levels (p-value = 0.03; R = 0.588). The NAb levels also showed significantly positive correlation with 25(OH)D level (p-value = 0.005; R = 0.561). The 25(OH)D levels were positively correlated with S-RBD IgG levels among subjects younger than 60 years old (p-value = 0.047; R = 0.136). However, serum 25 (OH)D levels showed no such correlation with S-RBD IgG levels among subjects older than 60 years old (p-value = 0.933; R = 0.136).ConclusionBoth anti-SARS-CoV-2 S-RBD IgG and NAb levels developed moderate correlation with 25(OH)D levels among subjects treated without chemotherapy. The S-RBD IgG levels also had positive correlation with 25(OH)D levels among subjects younger than 60 years old. Thus, we recommended cancer patients to maintain serum 25(OH)D levels above 30 ng/mL (75 nmol/L) to enhance the efficacy of COVID-19 vaccines.

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Section: Introductionmentioning

confidence: 99%

The correlation between serum 25-hydroxy-vitamin D levels and anti-SARS-CoV-2 S-RBD IgG and neutralizing antibody levels among cancer patients receiving COVID-19 vaccines

Rachman

Iriani²,

Priantono³

et al. 2022

Front. Nutr.

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“…In future studies, further experiments may be exerted in order to investigate the possibility to set up effective systems, such as nanotechnological systems, aimed at improving this vegetal extract’s pharmacokinetic features [60] , [61] . Indeed, nanotechnology may exert a central role in the delivery of natural bioactive compounds and nutraceuticals in the management of COVID-19-related conditions.…”

Section: Discussionmentioning

confidence: 99%

A potential host and virus targeting tool against COVID-19: Chemical characterization, antiviral, cytoprotective, antioxidant, respiratory smooth muscle relaxant effects of Paulownia tomentosa Steud

Magurano

Micucci

Nuzzo

et al. 2023

Biomedicine & Pharmacotherapy

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“…), hydroxyl (•OH), and nonradicals, e.g., organic peroxides and hydrogen peroxide. All of them have been characterized by exerting severe damage at both cell and tissue levels, culminating in the onset of multiple disorders [149,[152][153][154][155].…”

Section: Antioxidant Activity Of Seed Extract-mediated Npsmentioning

confidence: 99%

Biogenic Metallic Nanoparticles from Seed Extracts: Characteristics, Properties, and Applications

Bhardwaj

Chopra

Bhardwaj

et al. 2022

Journal of Nanomaterials

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Metal nanoparticles (MNPs) are popular in different research fields due to their unique physical and chemical properties and superior antimicrobial, anticancer, antioxidant, larvicidal, and catalytic potentials. Although conventional wet methods like colloidal synthesis, calcination, and spark ablation for synthesizing MNPs are effective, their synthesis uses an array of reducing and stabilizing agents and gases, making the process tedious. Additionally, metal nanoparticles induce oxidative stress through reactive oxygen species (ROS), showing high toxicity. Research and development in green chemistry have gained momentum and massive attention because of being efficient, clean, economical, environment-friendly, and free of hazardous byproducts. Recently, seed extracts in-lieu of chemical stabilizers and reducing agents have become popular because of the single-step green synthesis of MNPs. Seeds provide the researchers with a cost-effective alternate to other biological methods due to low maintenance costs, culture/growth independence for biomass, and diversity of phytochemicals as reducing and capping agents. Thus, effective green synthesis approaches are considered sustainable for MNP synthesis. This review depicts the literature on the challenges associated with metal and metal oxide nanoparticles and discusses their synthesis using seed extracts. The application section of the review discusses the antimicrobial, anticancer, and larvicidal activities of seed extracted-synthesized metallic nanoparticles. Furthermore, insights into the different biological potentials of the synthesized green MNPs have also been discussed.

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Nanoparticles in clinical trials of COVID-19: An update

Cited by 28 publications

References 112 publications

The correlation between serum 25-hydroxy-vitamin D levels and anti-SARS-CoV-2 S-RBD IgG and neutralizing antibody levels among cancer patients receiving COVID-19 vaccines

The correlation between serum 25-hydroxy-vitamin D levels and anti-SARS-CoV-2 S-RBD IgG and neutralizing antibody levels among cancer patients receiving COVID-19 vaccines

A potential host and virus targeting tool against COVID-19: Chemical characterization, antiviral, cytoprotective, antioxidant, respiratory smooth muscle relaxant effects of Paulownia tomentosa Steud

Biogenic Metallic Nanoparticles from Seed Extracts: Characteristics, Properties, and Applications

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