Nanoparticles for paclitaxel delivery: A comparative study of different types of dendritic polyesters and their degradation behavior

Liquid–liquid phase equilibria of hyperbranched polymers—Experimental study and modeling

“…Reul et al [50] studied the hydrolytic degradation behavior at physiological conditions (310.15 K, pH = 7.4) of the unmodified dendritic polyester Boltorn H-40 and the two HPBs U3000 and W3000 where the OH terminal groups are esterified by fatty acids and polyethylene glycol chains. After 24 h 6.95% and after 28 days 30.1% of the Boltorn H-40 was degraded.…”

Polyester Dendrimers: Smart Carriers for Drug Delivery

“…Other recent attempts to improve paclitaxel pharmacokinetic profiles include the work of Kissel and coworkers [197]. The authors aimed to formulate nanoparticles from three different hyperbranched polymers, namely unmodified dendritic polyester (Boltorn H40), a lipophilic, fatty acid modified dendritic polymer (Boltorn U3000), and an amphiphilic dendritic polymer (Boltorn W3000) (see Figure 6) for drug delivery of paclitaxel and to investigate their properties.…”

“…Boltorn series hyperbranched aliphatic polyesters have great potential for applications in the biomedical field [198] due to their low toxicity, immunogenicity [56], and biodegradability [63]. Here [197], a solvent displacement method allowed preparation of nanoparticles from all three hyperbranched polymers. The lipophilic Boltorn U3000 formed the biggest nanoparticles while the amphiphilic Boltorn W3000 formed the smallest ones.…”

“…Boltorn U3000 and W3000 represent interesting candidates for drug delivery application due to their high loading efficiency. [197].…”

Systematic aging of degradable nanosuspension ameliorates vibrating-mesh nebulizer performance

“…Mass loss of polymeric NP 10,23 Ten milliliter of purified nanosuspension (1 mg/ml) was transferred to 15 ml screw-cap tubes and incubated at 22 C while undergoing vertical rotation (Rotatherm, Gebr. Liebisch, Bielefeld, Germany).…”