Polyester Dendrimers: Smart Carriers for Drug Delivery

Twibanire, Amour K.; Grindley, T. Bruce

doi:10.3390/polym6010179

Cited by 78 publications

(51 citation statements)

References 213 publications

(247 reference statements)

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“…The use of advanced drug delivery systems for oral delivery may be necessary, especially when delivering BCS class II and IV drugs, but also if delivering peptides or proteins by the oral route (Twibanire and Grindley, 2014). It is therefore important to initially investigate the in vitro and in situ properties of the delivery system, in particular with respect to the release of the drug from the system in simulated media.…”

Section: Resultsmentioning

confidence: 99%

Polymeric microcontainers improve oral bioavailability of furosemide

Nielsen

Melero

Keller

et al. 2016

International Journal of Pharmaceutics

117

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Microcontainers with an inner diameter of 223 µm are fabricated using the polymer SU-8, and evaluated in vitro, in situ and in vivo for their application as an advanced oral drug delivery system for the poorly water soluble drug furosemide. An amorphous sodium salt of furosemide (ASSF) is filled into the microcontainers followed by applying a lid using Eudragit L100. It is possible to control the drug release in vitro, and in vitro absorption studies show that the microcontainers are not a hindrance for absorption of ASSF. In situ perfusion studies in rats are performed with ASSF-filled microcontainers coated with Eudragit and compared to a furosemide solution. The absorption rate constant of ASSF confined in microcontainers is found to be significantly different from the solution, and by light microscopy, it is observed that the microcontainers are engulfed by the intestinal mucus. An oral bioavailability study in rats is performed with ASSF confined in microcontainers coated with Eudragit and a control group with ASSF in Eudragit-coated capsules. A relative bioavailability of 220% for the ASSF in microcontainers compared to ASSF in capsules is found. These studies indicate that the microcontainers could serve as a promising oral drug delivery system.

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Section: Resultsmentioning

confidence: 99%

Polymeric microcontainers improve oral bioavailability of furosemide

Nielsen

Melero

Keller

et al. 2016

International Journal of Pharmaceutics

117

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“…4,[9][10][11] In industry, fumaric acid is mainly derived from the isomerization of the maleic acid in the presence of catalysts. [17][18][19] But these catalysts have some disadvantages, such as difficult to separate and reuse, etching apparatus and polluting environment. 12 Thiourea is used most commonly because of its low cost.…”

Section: Introductionmentioning

confidence: 99%

Study on the Isomerization of Maleic Acid to Fumaric Acid without Catalyst

Gao

Chen

Rothenberg

et al. 2018

Bulletin Korean Chem Soc

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Fumaric acid is an important food additive and industrial intermediate compound. The traditional methods of producing fumaric acid were catalyzed by maleic acid isomerization. In this study, isomerization of maleic acid in water without catalyst was investigated at elevated temperature, which addressed the problem of sewage discharge. HPLC analysis showed maleic acid converted into fumaric acid and small amount of malic acid simultaneously. The effects of concentration of maleic acid, reaction temperature, reaction time, and stirring on the yield of fumaric acid were investigated. The optimum reaction conditions were also explored. The results showed the isomerization of maleic acid reached equilibrium at about 1 h, stirring did not affect the reaction rate, and conversion due to the monomolecular mechanism. In order to achieve "zero emission," the recycle of filter liquor was also studied. The pH of filter liquor changing signifies the lower pH was in favor of the conversion of maleic acid to fumaric acid. The high yield and recyclability suggested that this process had promising application in fumaric acid production.

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“…This mainly included the synthesis of amphiphilic dendritic polymers with a hydrophobic core surrounded by a hydrophilic shell and their application in delivering hydrophobic compounds [5,6,7,8,9,10,11,12] and their applications in transferring water-soluble dyes [13,14,15], such as rose Bengal, Congo red, eosin Y, fluorescein, bromophenol blue, methyl red, and methyl orange, from an aqueous solution to n apolar solvent. Though both, dendrimers and hyperbranched dendrimers have been explored for dye encapsulation by a number of research groups [16,17,18,19,20], amphiphilic dendronized polymers still remain relatively unexplored. The major focus of our group is at the encapsulation of the hydrophilic fluorescent dye cyanine 3 (Cy3) that emits in the visible region (540-570 nm).…”

Section: Introductionmentioning

confidence: 99%