Nanoparticles for detection and diagnosis

Agasti, Sarit S.; Rana, Subinoy; Park, Myoung‐Hwan; Kim, Chae Kyu; You, Chang‐Cheng; Rotello, Vincent M.

doi:10.1016/j.addr.2009.11.004

Cited by 289 publications

(166 citation statements)

References 107 publications

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“…It is known that the composition of NPs (particularly semiconductor NPs such as quantum dots) is also able to affect the scattering properties; 47 recently, several studies have focused on the scattering properties dependent on the composition of Au nanocomplexes. [48][49][50] Jain et al 34 have investigated the scattering properties of the core-shell composition in silica-Au nanoshells using Mie theory and discrete dipole approximation method.…”

Section: Particle Compositionmentioning

confidence: 99%

Gold nanoparticles enlighten the future of cancer theranostics

Guo¹,

Rahme²,

Yan³

et al. 2017

IJN

221

120

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Development of multifunctional nanomaterials, one of the most interesting and advanced research areas in the field of nanotechnology, is anticipated to revolutionize cancer diagnosis and treatment. Gold nanoparticles (AuNPs) are now being widely utilized in bioimaging and phototherapy due to their tunable and highly sensitive optical and electronic properties (the surface plasmon resonance). As a new concept, termed “theranostics,” multifunctional AuNPs may contain diagnostic and therapeutic functions that can be integrated into one system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. In this review, the important properties of AuNPs relevant to diagnostic and phototherapeutic applications such as structure, shape, optics, and surface chemistry are described. Barriers for translational development of theranostic AuNPs and recent advances in the application of AuNPs for cancer diagnosis, photothermal, and photodynamic therapy are discussed

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Section: Particle Compositionmentioning

confidence: 99%

Gold nanoparticles enlighten the future of cancer theranostics

Guo¹,

Rahme²,

Yan³

et al. 2017

IJN

221

120

View full text Add to dashboard Cite

show abstract

“…To date, the existing technology for the detection of food-borne pathogens only meets the criteria of speed, sensitivity, and specificity when it uses large, laboratory-based, sophisticated and costly equipment (Hoorfar, 2011) Therefore, the development of a simplified, cost-effective and accurate procedure for detection of trace amounts of bacterial pathogens, which does not require complex instruments, seems to be imperious in order to overcome the time delay and allow rapid and sensitive detection (McGrath, Elliot, & Fodey, 2012) in infrastructure deprived environments. Nanotechnology, and more specifically gold nanoparticle chemistry, provides opportunities for the rapid and simple diagnosis of many infectious diseases, being able to detect trace amounts of bacteria, due to their uniqueoptical properties (Agasti et al, 2010;Syed & Bokhari, 2011). In the present study we developed and evaluated a gold nanoprobe assay, which does not require the amplification of the target DNA, but relies on the hybridization of the pathogen's DNA with gold nanoprobes with subsequent colorimetric differentiation.…”

Section: Introductionmentioning

confidence: 99%

A Simple Gold Nanoprobe Assay for the Identification of Staphylococcus Aureus, Listeria Monocytogenes and Salmonella Enteritidis in Food Specimens

Houhoula¹,

Charvalos²,

Konteles³

et al. 2017

JFR

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In the present study, we developed a gold nanoprobe assay, which relies on the colorimetric differentiation of specific DNA sequences, based on different aggregation profiles. We evaluated the assay on DNA extracted from pathogen cultures and from contaminated food specimens. The targets used were the femA gene for the identification of Staphylococcus aureus, the hly gene of the Listeria monocytogenes listeriolysin and the invA sequence for Salmonella spp. Comparison was performed with the reference assay, as described in the respective ISO guidelines for each pathogen, and a direct PCR amplification and detection. The minimum detection limit of the assay was defined at 123 fg/μL DNA, for all species, lower than PCR detection. Specificity was 100%. Sensitivity was 100%, as compared το the reference method, whereas the sensitivity of PCR was 93.3%. The evaluated assay could be used as a sensitive screening method, which does not require major infrastructure, for the detection and identification of pathogens in food specimens. In addition, it can accommodate detection of multiple species, thus allowing multiplexing and expedite turnaround time.

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“…More recently this research group evolved their initial design to 4 | J. Name., 2012, 00, [1][2][3] This journal is © The Royal Society of Chemistry 20xx…”

Section: Nanogates Based On Dna Quadruplexesmentioning

confidence: 99%

“…Moreover, the use of nanoparticles as core platforms for those devices could provide novel and interesting hybrids as detection, diagnosis and/or therapeutic effect features to these devices, [1][2][3] which are two fundamental applications of nanoparticles in biotechnology. Related with cancer, nanometre sized particles offer a unique platform for the development of both therapeutic and diagnosis devices.…”

Section: Introductionmentioning

confidence: 99%

Recent applications of the combination of mesoporous silica nanoparticles with nucleic acids: development of bioresponsive devices, carriers and sensors

Castillo¹,

Baeza²

2017

Biomater. Sci.

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The discovery and control of the biological roles mediated by nucleic acids have turned them into a powerful tool for the development of advanced biotechnological materials. Much is the importance of those gene-keeping biomacromolecules that even nanomaterials have succumbed to the claimed benefits of DNA and RNA. Currently, there could be found in the literature a practically intractable number of examples which report the use in combination of nanoparticles with nucleic acids, which demands boundedness. Following this premise, this revision will only cover the most recent and powerful strategies developed to exploit the possibilities of nucleic acids as biotechnological materials when in combination with mesoporous silica nanoparticles. The extensive research done on nucleic acids has significantly incremented the technological possibilities for those biomacromolecules, which could be employed in many different applications; where substrate or sequence recognition or modulation of biological pathways due to its coding role in living cells are the most promising. In the present revision, the chosen counterpart, mesoporous silica nanoparticles, also with unique properties, became a reference material for drug delivery and biomedical applications due to their high biocompatibility and porous structure suitable for hosting and delivering small molecules. Although most of revisions deal with significant advances in the use of nucleic acid and mesoporous silica nanoparticles in biotechnological applications, a rationale classification of those new generation hybrid materials is still uncovered. Along this review there will be covered promising strategies for living cell and biological sensors, DNA-based molecular gates with targeting, transfection or silencing properties which could provide a significant advance of current nanomedicine.

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Nanoparticles for detection and diagnosis

Cited by 289 publications

References 107 publications

Gold nanoparticles enlighten the future of cancer theranostics

Gold nanoparticles enlighten the future of cancer theranostics

A Simple Gold Nanoprobe Assay for the Identification of Staphylococcus Aureus, Listeria Monocytogenes and Salmonella Enteritidis in Food Specimens

Recent applications of the combination of mesoporous silica nanoparticles with nucleic acids: development of bioresponsive devices, carriers and sensors

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