Gold nanoparticles enlighten the future of cancer theranostics

Guo, Jianfeng; Rahme, Kamil; Yan, He; Li, Linlin; Holmes, Justin D.; O’Driscoll, Caitriona M.

doi:10.2147/ijn.s140772

Cited by 215 publications

(124 citation statements)

References 186 publications

Supporting

Mentioning

116

Contrasting

Unclassified

Order By: Relevance

“…The excellent stability of GNP stabilized with thiolated ligands permits chemical reactions directly on their surface . The ligands used to stabilize GNP may be specifically chosen for drug encapsulation and release, or to target specific tissues, such as tumors …”

Section: Introductionmentioning

confidence: 99%

Gold nanoparticles in ophthalmology

Masse

Ouellette

Lamoureux

et al. 2018

Medicinal Research Reviews

View full text Add to dashboard Cite

Many research projects are underway to improve the diagnosis and therapy in ophthalmology. Indeed, visual acuity deficits affect 285 million people worldwide and different strategies are being developed to strengthen patient care. One of these strategies is the use of gold nanoparticles (GNP) for their multiple properties and their ability to be used as both diagnosis and therapy tools. This review exhaustively details research developing GNPs for use in ophthalmology. The toxicity of GNPs and their distribution in the eye are described through in vitro and in vivo studies. All publications addressing the pharmacokinetics of GNPs administered in the eye are extensively reviewed. In addition, their use as biosensors or for imaging with optical coherence tomography is illustrated. The future of GNPs for ophthalmic therapy is also discussed. GNPs can be used to deliver genes or drugs through different administration routes. Their antiangiogenic and anti-inflammatory properties are of great interest for different ocular pathologies. Finally, GNPs can be used to improve stereotactic radiosurgery, brachytherapy, and photothermal therapy because of their many properties.

show abstract

Section: Introductionmentioning

confidence: 99%

Gold nanoparticles in ophthalmology

Masse

Ouellette

Lamoureux

et al. 2018

Medicinal Research Reviews

View full text Add to dashboard Cite

show abstract

“…Salinomycin (Sal) is a polyether ionophore antibiotic that has been shown to kill CSCs in different types of human cancers . On the other hand, gold nanoparticles (AuNPs) are excellent drug carriers with good biocompatibility, easy synthesis and good drug functionalization capability . Studies have found that salinomycin‐loaded gold nanoparticles can induce ferroptosis in CSCs …”

Section: Progress In Ferroptosis Application In Cancer Therapymentioning

confidence: 99%

Ferroptosis: Final destination for cancer?

et al. 2020

View full text Add to dashboard Cite

Ferroptosis is a recently defined, non‐apoptotic, regulated cell death (RCD) process that comprises abnormal metabolism of cellular lipid oxides catalysed by iron ions or iron‐containing enzymes. In this process, a variety of inducers destroy the cell redox balance and produce a large number of lipid peroxidation products, eventually triggering cell death. However, in terms of morphology, biochemistry and genetics, ferroptosis is quite different from apoptosis, necrosis, autophagy‐dependent cell death and other RCD processes. A growing number of studies suggest that the relationship between ferroptosis and cancer is extremely complicated and that ferroptosis promises to be a novel approach for the cancer treatment. This article primarily focuses on the mechanism of ferroptosis and discusses the potential application of ferroptosis in cancer therapy.

show abstract

“…Types of Nano Sized Vehicles that are used for Theranostic Applications: 1. Gold and Iron oxide Nanoparticles: 5 Attractive for their size, stability, and biocompatibility, gold nanoparticles (NPs) continue to gain interest due to their potential to enhance a number of biomedical applications. More importantly, the ability to functionalize the surface of gold with organic molecules allows for the preparation of nanoparticles which can specifically interact with any physiological system polymer-functionalized metallic nanoparticles featuring a gold core are, in fact, suitable for traditional characterization methods in solution and, therefore, present an attractive opportunity for manufacturing drug delivery vehicles with tuneable properties.…”

Section: They Are Safe and Can Undergo Biodegradationmentioning

confidence: 99%

Untitled

2018

IJPSR

View full text Add to dashboard Cite

An object with at least one characteristic dimension between 1 and 100 nm can be defined as "nanomaterial". The unbelievable development of nanotechnology in the last 30 years has allowed the release of new and efficient synthetic routes towards the production and functionalization of different NPs, composed of a variety of materials including noble metals (e.g. gold and silver), semiconductors, TiO 2 , magnetic compounds and their combinations, such as core-shell and alloy. Advances in nanoparticle synthesis and engineering have produced nanoscale agents affording both therapeutic and diagnostic functions that are often referred to by the portmanteau 'Nanotheronostics'. The field is associated with many applications in the clinic, especially in cancer management. These include patient stratification, drug-release monitoring, imaging-guided focal therapy and post-treatment response monitoring NPs which is clearly elaborated in this work. Intelligent nanotheronostics based on bio responsive systems have recently emerged and offer the promise of high specificity and efficiency via "on-demand" activation of both therapeutic and diagnostic capabilities are being widely used for cancer diagnostics. As this development is very sensitive in terms and diagnosis and treatment proper regulations have been implemented in several countries and the regulations in few of the developed countries have been discussed in this article. INTRODUCTION: Theranostics 1 " is a novel multifunctional approach that describes any "material that combines the modalities of therapy and diagnostic imaging" into a single package. Nanotheronostics can deliver treatment while simultaneously monitoring therapy response in real-time, thereby decreasing the potential of overor under-dosing patients.

show abstract

Gold nanoparticles enlighten the future of cancer theranostics

Cited by 215 publications

References 186 publications

Gold nanoparticles in ophthalmology

Gold nanoparticles in ophthalmology

Ferroptosis: Final destination for cancer?

Untitled

Contact Info

Product

Resources

About