Gold nanoparticles in ophthalmology

Masse, Florence; Ouellette, Mathieu; Lamoureux, Guillaume; Boisselier, Élodie

doi:10.1002/med.21509

Cited by 82 publications

(62 citation statements)

References 167 publications

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“…Gold nanoparticles are known to have many advantages in electrochemistry in that they are highly conductive, allow a faster electron transfer kinetics, increase the electroactive surface of the electrode, and reduce the risks of overvoltage [28,29]. Moreover, depending on the synthesis method, they can be biocompatible and are consequently being used more and more frequently in nanomedicine [30,31]. Recent works have also highlighted the usefulness of gold nanoparticles in electrochemistry [32].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Detection of Dopamine Based on Functionalized Electrodes

et al. 2019

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The rapid electrochemical identification and quantification of neurotransmitters being a challenge in the ever-growing field of neuroelectronics, we aimed to facilitate the electrochemical selective detection of dopamine by functionalizing commercially available electrodes through the deposition of a thin film containing pre-formed gold nanoparticles. The influence of different parameters and experimental conditions, such as buffer solution, fiber material, concentration, and cyclic voltammetry (CV) cycle number, were tested during neurotransmitter detection. In each case, without drastically changing the outcome of the functionalization process, the selectivity towards dopamine was improved. The detected oxidation current for dopamine was increased by 92%, while ascorbic acid and serotonin oxidation currents were lowered by 66% under the best conditions. Moreover, dopamine sensing was successfully achieved in tandem with home-made triple electrodes and an in-house built potentiostat at a high scan rate mode.

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Section: Introductionmentioning

confidence: 99%

Electrochemical Detection of Dopamine Based on Functionalized Electrodes

et al. 2019

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“…Although the protein antibodies, such as IgG and Fab, are known to be smaller than the retinal layer nanopores and they penetrate the retina freely, nanoparticles accumulate on the inner retina, which is supported by previous animal experiments with gold nanoparticles. 25 …”

Section: Resultsmentioning

confidence: 99%

Intraocular Distribution and Kinetics of Intravitreally Injected Antibodies and Nanoparticles in Rabbit Eyes

Kim

Hong

et al. 2020

Trans. Vis. Sci. Tech.

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Purpose To investigate the intraocular distribution and kinetics of antibodies and nanoparticles in the experimental model. Methods Antibodies (whole IgG 149kDa, antigen-binding fragments 48.39 kDa) and four kinds of nondegradable nanoparticles (25, 50, 200, and 250 nm) were intravitreally injected in the right eye of New Zealand white rabbits. The average optical density and concentration were used to measure intraocular distribution and kinetics. Results After intravitreal injection, antibodies were distributed throughout the vitreous humor and eliminated gradually into anterior and posterior routes. Fluorescence intensity decreased 1 day after injection and was not detected 25 days after injection. The nondegradable nanoparticles migrated posteriorly to the retina 7 days after injection onward and anteriorly to the aqueous humor from 1 hour to 1 day after injection. The fluorescence intensity of the nanoparticles was relatively stable in the vitreous humor, compared to antibodies. Nanoparticles accumulated on the internal limiting membrane of the retina with no penetration into deeper retinal tissue, whereas the smaller size 25 nm nanoparticles passed across the ciliary body and moved into choroid, retina, and suprachoroidal space. A gradual decrease of nanoparticles by their sizes in the vitreous after 30 days after injection was described as the percentage ratio: 61.1% (25 nm), 69.1% (50 nm), 78.6% (200nm), and 85.3% (250 nm). Conclusions Our study revealed the in vivo intraocular distribution and kinetics of antibodies and nanoparticles with diverse sizes and the result might help to develop newer intraocular drugs and drug delivery systems to treat retinal diseases. Translational Relevance These experimental results can be valuable data for human research.

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“…Besides this, these nanoparticles help in retaining the drug for several weeks at the desired level. Glaucoma, retinal diseases, AMD, corneal fibrosis, retinoblastoma (RB), ocular inflammation are some of the disorders that have been efficiently treated using inorganic nanoparticles as drug delivery systems [ 44 ].…”

Section: Need For Nanomedicine For Ocular Drug Deliverymentioning

confidence: 99%

Nano-Based Drug Delivery System: Recent Strategies for the Treatment of Ocular Disease and Future Perspective

Qamar

Qizilbash

Iqubal

et al. 2020

DDF

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The structure of the eye is very complex in nature which makes it a challenging task for pharmaceutical researchers to deliver the drug at the desired sites via different routes of administration. The development of the nano-based system helped in delivering the drug in the desired concentration. Improvement in penetration property, bioavailability, and residence time has all been achieved by encapsulating drugs into liposomes, dendrimers, solid lipid nanoparticle, nanostructured lipid carrier, nanoemulsion, and nanosuspension. This review puts emphasis on the need for nanomedicine for ocular drug delivery and recent developments in the field of nanomedicine along with recent patents published in the past few years.

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Gold nanoparticles in ophthalmology

Cited by 82 publications

References 167 publications

Electrochemical Detection of Dopamine Based on Functionalized Electrodes

Electrochemical Detection of Dopamine Based on Functionalized Electrodes

Intraocular Distribution and Kinetics of Intravitreally Injected Antibodies and Nanoparticles in Rabbit Eyes

Nano-Based Drug Delivery System: Recent Strategies for the Treatment of Ocular Disease and Future Perspective

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