Nanoparticles as synthetic vaccines

Smith, Josiah D.; Morton, Logan D; Ulery, Bret D.

doi:10.1016/j.copbio.2015.03.014

Cited by 86 publications

(53 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Their main advantage lies in how much control can be achieved over their synthesis [87,88]. Inorganic particles have been used as both adjuvants and antigen delivery vehicles in order to enhance an immune response [89]. The four most commonly used types of inorganic particles deployed in vaccines are: gold, aluminium, calcium phosphate and silica.…”

Section: Inorganic Particlesmentioning

confidence: 99%

Novel approaches for the design, delivery and administration of vaccine technologies

Wallis

Shenton

Carlisle

2019

Clinical and Experimental Immunology

View full text Add to dashboard Cite

Summary It is easy to argue that vaccine development represents humankind’s most important and successful endeavour, such is the impact that vaccination has had on human morbidity and mortality over the last 200 years. During this time the original method of Jenner and Pasteur, i.e. that of injecting live‐attenuated or inactivated pathogens, has been developed and supplemented with a wide range of alternative approaches which are now in clinical use or under development. These next‐generation technologies have been designed to produce a vaccine that has the effectiveness of the original live‐attenuated and inactivated vaccines, but without the associated risks and limitations. Indeed, the method of development has undoubtedly moved away from Pasteur’s three Is paradigm (isolate, inactivate, inject) towards an approach of rational design, made possible by improved knowledge of the pathogen–host interaction and the mechanisms of the immune system. These novel vaccines have explored methods for targeted delivery of antigenic material, as well as for the control of release profiles, so that dosing regimens can be matched to the time‐lines of immune system stimulation and the realities of health‐care delivery in dispersed populations. The methods by which vaccines are administered are also the subject of intense research in the hope that needle and syringe dosing, with all its associated issues regarding risk of injury, cross‐infection and patient compliance, can be replaced. This review provides a detailed overview of new vaccine vectors as well as information pertaining to the novel delivery platforms under development.

show abstract

Section: Inorganic Particlesmentioning

confidence: 99%

Novel approaches for the design, delivery and administration of vaccine technologies

Wallis

Shenton

Carlisle

2019

Clinical and Experimental Immunology

View full text Add to dashboard Cite

show abstract

“…Liposomes are the second-most common type of NP, and they self-assemble in water under special conditions. They are composed of lipids, which have a hydrophilic head and a hydrophobic tail that maintain hydrophilic inner and outer membranes, in lamellar lipid bilayers or in multilayers that simulate vesicles found within cells [22]. Liposomes can induce cellular responses or humoral responses, depending on the charge, size, and lipid composition.…”

Section: Liposomesmentioning

confidence: 99%

Nanoparticle-based vaccines

Díaz-Arévalo

Zeng

2020

Nanopharmaceuticals

View full text Add to dashboard Cite

“…Other inorganic nanoscale assemblies based on silica, aluminum, and calcium phosphate, have been used in an attempt to develop effective vaccine candidates [144]. However, many of the same problems occur with all classes.…”

Section: Nanotechnology and Nanovaccinesmentioning

confidence: 99%

Vaccine technologies: From whole organisms to rationally designed protein assemblies

Karch¹,

Burkhard²

2016

Biochemical Pharmacology

215

185

View full text Add to dashboard Cite

Vaccines have been the single most significant advancement in public health, preventing morbidity and mortality in millions of people annually. Vaccine development has traditionally focused on whole organism vaccines, either live attenuated or inactivated vaccines. While successful for many different infectious diseases whole organisms are expensive to produce, require culture of the infectious agent, and have the potential to cause vaccine associated disease in hosts. With advancing technology and a desire to develop safe, cost effective vaccine candidates, the field began to focus on the development of recombinantly expressed antigens known as subunit vaccines. While more tolerable, subunit vaccines tend to be less immunogenic. Attempts have been made to increase immunogenicity with the addition adjuvants, either immunostimulatory molecules or an antigen delivery system that increases immune responses to vaccines. An area of extreme interest has been the application of nanotechnology to vaccine development, which allows for antigens to be expressed on a particulate delivery system. One of the most exciting examples of nanovaccines are rationally designed protein nanoparticles. These nanoparticles use some of the basic tenants of structural biology, biophysical chemistry, and vaccinology to develop protective, safe, and easily manufactured vaccines. Rationally developed nanoparticle vaccines are one of the most promising candidates for the future of vaccine development.

show abstract

Nanoparticles as synthetic vaccines

Cited by 86 publications

References 49 publications

Novel approaches for the design, delivery and administration of vaccine technologies

Novel approaches for the design, delivery and administration of vaccine technologies

Nanoparticle-based vaccines

Vaccine technologies: From whole organisms to rationally designed protein assemblies

Contact Info

Product

Resources

About