Nanoparticles and nanomaterials as inevitable modern toxic agents. Review. Part 2. Main areas of research on toxicity and techniques to measure a content of nanoparticles in tissues

Ivlieva, Aleksandra Leonidovna; Zinicovscaia, Inga; Petritskaya, E. N.; Рогаткин, Д. А.

doi:10.17816/humeco100156

Cited by 1 publication

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References 68 publications

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“…In contrast to in vitro studies, the results of in vivo toxicity are inconsistent [1,9,[13][14][15][16][17][18][19][20][21]. Analysis of the reasons for the inconsistent results of most in vivo studies is limited to general ideas about the NPs' size, concentration and exposure time [22].…”

Section: Introductionmentioning

confidence: 99%

Transformation of Nano-Size Titanium Dioxide Particles in the Gastrointestinal Tract and Its Role in the Transfer of Nanoparticles through the Intestinal Barrier

Ryabtseva,

Umanskaya,

Shevchenko

et al. 2023

IJMS

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In this work, the size transformation of the TiO2 nanofraction from pharmaceutical grade E171 powder was studied during its transit through the gastrointestinal tract (GIT). It was shown that pharmaceutical-grade TiO2 powder contained about 0.68% (w/w) of particles smaller than 240 nm in diameter. In the observed GIT transit process the TiO2 nanoparticles were agglomerated up to 150–200 nm in simulated salivary fluid, with gradual agglomerate enlargement up to 300–600 nm and more than 1 micron in simulated gastric fluid. In the intestinal fluid the reverse process occurred, involving a decrease of agglomerates accompanied by the formation of a small fraction with ~50 nm average size. This fraction can be further involved in the histohematic transport process. The acidity degree (pH) and mineral composition of solutions, as well as the transit speed along the gastrointestinal tract, influence the nature of the particle transformation significantly. The rapid passing between the gastrointestinal tract sections creates conditions for a decrease in part of the TiO2 particles, up to 100 nm, and may be associated with the violation of the structural and functional integrity of the intestinal mucus layer.

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