Transformation of Nano-Size Titanium Dioxide Particles in the Gastrointestinal Tract and Its Role in the Transfer of Nanoparticles through the Intestinal Barrier
M. S. Ryabtseva,
S. F. Umanskaya,
M. A. Shevchenko
et al.
Abstract:In this work, the size transformation of the TiO2 nanofraction from pharmaceutical grade E171 powder was studied during its transit through the gastrointestinal tract (GIT). It was shown that pharmaceutical-grade TiO2 powder contained about 0.68% (w/w) of particles smaller than 240 nm in diameter. In the observed GIT transit process the TiO2 nanoparticles were agglomerated up to 150–200 nm in simulated salivary fluid, with gradual agglomerate enlargement up to 300–600 nm and more than 1 micron in simulated gas… Show more
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