Nanoparticles: A New Approach to Upgrade Cancer Diagnosis and Treatment

Yu, Zhenhua; Gao, Lei; Chen, Kehan; Zhang, Wenqiang; Zhang, Qihang; Li, Quanwang; Hu, Kaiwen

doi:10.1186/s11671-021-03489-z

Cited by 92 publications

(68 citation statements)

References 134 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Specifically, anti-tumor research has increasingly utilized nanoparticles (NPs) as carriers due to attractive pharmacokinetic and biodistribution properties, as well as reduced toxicity to the rest of the body. Recent reviews have highlighted various NP strategies aimed at enhancing imaging for diagnosis and drug efficacy for therapy [ 4 , 5 ]. Compared to alternative clinical contrast agents, NPs tend to exhibit higher sensitivity and/or specificity for abnormalities such as tumors due to selective delivery [ 6 ], including preclinical studies that have shown promise for computed tomography, magnetic resonance imaging, ultrasound, and positron emission tomography (see reviews: [ 7 , 8 ]).…”

Section: Introductionmentioning

confidence: 99%

Quantifying and controlling bond multivalency for advanced nanoparticle targeting to cells

2021

View full text Add to dashboard Cite

Nanoparticles have drawn intense interest as delivery agents for diagnosing and treating various cancers. Much of the early success was driven by passive targeting mechanisms such as the enhanced permeability and retention (EPR) effect, but this has failed to lead to the expected clinical successes. Active targeting involves binding interactions between the nanoparticle and cancer cells, which promotes tumor cell-specific accumulation and internalization. Furthermore, nanoparticles are large enough to facilitate multiple bond formation, which can improve adhesive properties substantially in comparison to the single bond case. While multivalent binding is universally believed to be an attribute of nanoparticles, it is a complex process that is still poorly understood and difficult to control. In this review, we will first discuss experimental studies that have elucidated roles for parameters such as nanoparticle size and shape, targeting ligand and target receptor densities, and monovalent binding kinetics on multivalent nanoparticle adhesion efficiency and cellular internalization. Although such experimental studies are very insightful, information is limited and confounded by numerous differences across experimental systems. Thus, we focus the second part of the review on theoretical aspects of binding, including kinetics, biomechanics, and transport physics. Finally, we discuss various computational and simulation studies of nanoparticle adhesion, including advanced treatments that compare directly to experimental results. Future work will ideally continue to combine experimental data and advanced computational studies to extend our knowledge of multivalent adhesion, as well as design the most powerful nanoparticle-based agents to treat cancer.

show abstract

Section: Introductionmentioning

confidence: 99%

Quantifying and controlling bond multivalency for advanced nanoparticle targeting to cells

2021

View full text Add to dashboard Cite

show abstract

“…Nanoparticle systems are currently being developed to reduce the adverse effects of standard chemo-and radiotherapeutics. The use of these nanoparticle systems can be beneficial in improving hydrophobic drug delivery and in reducing metabolic drug degradation and targeting specific cells [204,205].…”

Section: Synergistic Effect Of Cap and Nanoparticlesmentioning

confidence: 99%

Effect of Cold Atmospheric Plasma on Epigenetic Changes, DNA Damage, and Possibilities for Its Use in Synergistic Cancer Therapy

Braný

Dvorska

Strnádel

et al. 2021

IJMS

View full text Add to dashboard Cite

Cold atmospheric plasma has great potential for use in modern medicine. It has been used in the clinical treatment of skin diseases and chronic wounds, and in laboratory settings it has shown effects on selective decrease in tumour-cell viability, reduced tumour mass in animal models and stem-cell proliferation. Many researchers are currently focusing on its application to internal structures and the use of plasma-activated liquids in tolerated and effective human treatment. There has also been analysis of plasma’s beneficial synergy with standard pharmaceuticals to enhance their effect. Cold atmospheric plasma triggers various responses in tumour cells, and this can result in epigenetic changes in both DNA methylation levels and histone modification. The expression and activity of non-coding RNAs with their many important cell regulatory functions can also be altered by cold atmospheric plasma action. Finally, there is ongoing debate whether plasma-produced radicals can directly affect DNA damage in the nucleus or only initiate apoptosis or other forms of cell death. This article therefore summarises accepted knowledge of cold atmospheric plasma’s influence on epigenetic changes, the expression and activity of non-coding RNAs, and DNA damage and its effect in synergistic treatment with routinely used pharmaceuticals.

show abstract

“…As nanotechnology develops, it is necessary to monitor the immunotoxicity, long-term toxicity, and neurotoxicity of NPs. NPs would be an ideal approach to improve cancer therapy and diagnosis [ 137 ].…”

Section: Perspectivementioning

confidence: 99%

α-Mangostin Nanoparticles Cytotoxicity and Cell Death Modalities in Breast Cancer Cell Lines

et al. 2021

View full text Add to dashboard Cite

α-Mangostin (AMG) is a potent anticancer xanthone that was discovered in mangosteen (Garcinia mangostana Linn.). AMG possesses the highest opportunity for chemopreventive and chemotherapeutic therapy. AMG inhibits every step in the process of carcinogenesis. AMG suppressed multiple breast cancer (BC) cell proliferation and apoptosis by decreasing the creation of cancerous compounds. Accumulating BC abnormalities and their associated molecular signaling pathways promotes novel treatment strategies. Chemotherapy is a commonly used treatment; due to the possibility of unpleasant side effects and multidrug resistance, there has been substantial progress in searching for alternative solutions, including the use of plant-derived natural chemicals. Due to the limitations of conventional cancer therapy, nanotechnology provides hope for effective and efficient cancer diagnosis and treatment. Nanotechnology enables the delivery of nanoparticles and increased solubility of drugs and drug targeting, resulting in increased cytotoxicity and cell death during BC treatment. This review summarizes the progress and development of AMG’s cytotoxicity and the mechanism of death BC cells. The combination of natural medicine and nanotechnology into a synergistic capital will provide various benefits. This information will aid in the development of AMG nanoparticle preparations and may open up new avenues for discovering an effective BC treatment.

show abstract

Nanoparticles: A New Approach to Upgrade Cancer Diagnosis and Treatment

Cited by 92 publications

References 134 publications

Quantifying and controlling bond multivalency for advanced nanoparticle targeting to cells

Quantifying and controlling bond multivalency for advanced nanoparticle targeting to cells

Effect of Cold Atmospheric Plasma on Epigenetic Changes, DNA Damage, and Possibilities for Its Use in Synergistic Cancer Therapy

α-Mangostin Nanoparticles Cytotoxicity and Cell Death Modalities in Breast Cancer Cell Lines

Contact Info

Product

Resources

About