Nanoparticle synthesis approaches at a glance

Muhammad, Wali; Haleem, Iqra; Ullah, Naimat; Khan, Muhammad Qasim; N, Senthil Kumar

doi:10.26524/nr1931

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…[3,4] A new dimension has been opened by the functionally tunable nanosized materials for industrial, biomedical, and scientific purposes, which provides a set of techniques that allow the manipulation of structural and functional properties on a microscale. [5,6] Nanotechnology is kindred with the biomedicinal involvement of nanoparticles (NPs), which are not only used as the backbone in the vaccine to formulate "nanovaccines," nanomaterial-based antiviral agents, disinfectants; which inhibit the multiplication within the host or inactivate them outside the host, but also the application of designed nanorobots to detect and repairs of tissue defects at the cellular level. [7,8] Unlike the conventional drug formulations, which typically circulate throughout the entire body parts, nanoparticles may target a desired part of the body as a targeted drug delivery vehicle.…”

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confidence: 99%

Nanotechnology: A Potential Weapon to Fight against COVID‐19

Tiwari

Mishra

Pandey

et al. 2021

Part & Part Syst Charact

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the phylogenetic and taxonomical finding on February 11, the coronavirus (COV) study group (CGS) of the International Committee on Virus Taxonomy (ICTV) designated the virus as SARS-CoV-2. [1] The same day, the director general of the World Health Organization (WHO) designated the disease caused by SARS-CoV-2 "coronavirus disease 2019" (COVID-19). The WHO declared COVID-19 a pandemic On March 11, 2020. Globally as of June 2021, 179 686 071 confirmed cases of COVID-19, including 3 899 172 deaths, reported by WHO. [2] Reducing the burden of COVID-19 infection by developing vaccines and antiviral drugs is still a big challenge for researchers and clinicians.Nowadays, nanotechnology is a promising player in the scientific and medical fields with many applications. [3,4] A new dimension has been opened by the functionally tunable nanosized materials for industrial, biomedical, and scientific purposes, which provides a set of techniques that allow the manipulation of structural and functional properties on a microscale. [5,6] Nanotechnology is kindred with the biomedicinal involvement of nanoparticles (NPs), which are not only used as the backbone in the vaccine to formulate "nanovaccines," nanomaterial-based antiviral agents, disinfectants; which inhibit the multiplication within the host or inactivate them outside the host, but also the application of designed nanorobots to detect and repairs of tissue defects at the cellular level. [7,8] Unlike the conventional drug formulations, which typically circulate throughout the entire body parts, nanoparticles may target a desired part of the body as a targeted drug delivery vehicle. Compared to conventional vaccines, nanovaccines or surface-functionalized nanoparticles can be designed, explicitly targeting lymphatic organs and immune cells to provoke better immune responses. Moreover, the localized infections are challenging to be treated by the conventional vaccines but can be treated by the nanovaccines with specific cells or organ-targeting molecules. In some cases, the nanobased settings are applied to enhance the solubility of hydrophobic compounds. These systems are helpful to protect the antigens from degradation and stabilize a large number of therapeutic biomolecules, such as peptides, proteins, and nucleic acids on the substrate. [9] Viral infections, particularly COVID-19, have posed a severe threat to public health globally because of their wide-sphered distribution and their potent ability to change the genetic makeup. [10] Unfortunately, viruses have adopted various alternative tacticsThe COVID-19 infections have posed an unprecedented global health emergency, with nearly three million deaths to date, and have caused substantial economic loss globally. Hence, an urgent exploration of effective and safe diagnostic/therapeutic approaches for minimizing the threat of this highly pathogenic coronavirus infection is needed. As an alternative to conventional diagnosis and antiviral agents, nanomaterials have a great potential to cope with the current or even futu...

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confidence: 99%

Nanotechnology: A Potential Weapon to Fight against COVID‐19

Tiwari

Mishra

Pandey

et al. 2021

Part & Part Syst Charact

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“…[ 1,2 ] A lot of opportunities have been opened by the ability of nanosized materials for industries and scientific endeavors because nanotechnology is essentially a set of techniques that allow properties to be manipulated on a very small scale. [ 3,4 ] Currently, nanotechnology in the horizon of medicine offers some exciting possibilities. [ 5,6 ] Some methods are just considered, while others are at various experimental levels, or are currently being used.…”

Section: Introductionmentioning

confidence: 99%

Antiviral Activity of Nanomaterials against Coronaviruses

Muhammad

Zhai

Gao

2020

Macromolecular Bioscience

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NPs may target a desired part of the body, whereas conventional drug formulations typically distribute throughout the entire body. In the case of nanovaccines, they can be designed to better target lymphatic organs and immune cells to promote better immune responses than the conventional vaccines. Sometimes the localized infection is difficult to be reached by the conventional vaccines, but can be cured by the nanovaccines with specific cells or organs-targeting molecules. In some situations, the nano-based systems are used to enhance the solubility of hydrophobic compounds. These systems not only preserve the reliability of antigens toward degradation but also stabilize a large number of therapeutic agents such as peptides, proteins, and nucleic acids. [9] Viral infections can pose challenges for global public health because of their problematic widespreading distribution and their potential to develop through genetic mutation. [10] Viral infections cause a high number of deaths and a disturbing health care system in a few decades. [10] Recently, a new strain of coronavirus (severe acute respiratory syndrome coronavirus-2, SARS-CoV-2) has led to a pandemic situation that killed 597 583 (WHO, July 19, 2020) with millions of cases all over the world. The CoV belongs to the Coronaviridae family of Nidovirales order, [11-13] whose genomes usually range from 26 to 32 kb. [14] These viruses are called Coronaviruses (CoVes) because of the protruding spike proteins on their envelope that give the virions of crown-shaped. [15,16] Six CoVes species are responsible for the infection of humans, in which four of them (229E, OC43, NL63, and HKU1) are predominant and cause symptoms of a common cold in immunocompetent individuals. [17] While the other two strains are known as severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), which cause fatal diseases. [18,19] The acute respiratory cases appeared in early 2003 in China were caused by SARS-CoV, [20,21] while the MERS-CoV was the responsible pathogen for the Middle East outbreaks of severe respiratory disease in 2012. [22,23] The novel strain (SARS-CoV-2) caused pneumonia that seriously contributed to lung injuries. Identified scanning electron microscopy (SEM) image of SARS-CoV-2 is shown in Figure 1. The disease caused by this serious strain is termed as coronavirus diseases 2019 (COVID-19). To reduce infectious disease transmission, suitable methods are required based on the nature of the disease and mode of transmission. [24] For instance, vaccination is required for some One of the challenges facing by world nowadays is the generation of new pathogens that cause public health issues. Coronavirus (CoV) is one of the severe pathogens that possess the RNA (ribonucleic acid) envelop, and extensively infect humans, birds, and other mammals. The novel strain "SARS-CoV-2" (severe acute respiratory syndrome coronavirus-2) causes deadly infection all over the world and presents a pandemic situation nowadays. The SARS...

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Bismuth Nanoparticles Against Microbial Infections

Neamati

Kodori

Feizabadi

et al. 2022

Nanomedicine (Lond.)

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The destructive effect of infectious diseases on human life and the emergence of antibiotic-resistant strains highlight the importance of developing new and appropriate treatment strategies, one of which is the use of metals as therapeutic agents. Bismuth nanoparticles are an example of prominent metal-containing drugs. The therapeutic effects of bismuth-based drugs in the treatment of wounds have been proven. Various laboratory studies have confirmed the antimicrobial effects of bismuth nanoparticles, including the clinical treatment of ulcers caused by Helicobacter pylori. Therefore, considering the performance of this nanoparticle and its potent effect on infectious agents and its therapeutic dimensions, the present study fully investigated the properties and performance of this metal-based nanoparticle.

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Nanoparticle synthesis approaches at a glance

Cited by 4 publications

References 22 publications

Nanotechnology: A Potential Weapon to Fight against COVID‐19

Nanotechnology: A Potential Weapon to Fight against COVID‐19

Antiviral Activity of Nanomaterials against Coronaviruses

Bismuth Nanoparticles Against Microbial Infections

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