Nanoparticle Superstructures Made by Polymerase Chain Reaction: Collective Interactions of Nanoparticles and a New Principle for Chiral Materials

Chen, Wei; Bian, Ai; Agarwal, Ashish; Liu, Liqiang; Shen, Hujun; Wang, Libing; Xu, Chuanlai; Kotov, Nicholas A.

doi:10.1021/nl900726s

Cited by 233 publications

(302 citation statements)

References 57 publications

Supporting

Mentioning

290

Contrasting

Unclassified

Order By: Relevance

“…These researchers also reported that chiral pyramidal structures were produced using four types of AuNPs of different sizes. Similar chiral AuNP assemblies have been independently prepared by Chen et al 21 Kim et al 22 also reported on pyramidal or octahedral structures created with AuNPs and DNA, in which the AuNPs were located at the vertices of the polyhedrons. These researchers called the method 'aqueous-phase anisotropic sequential ligand replacement strategy' , and it could attach DNA strands up to six times at right angles to each other on an AuNP (Figure 2e).…”

Section: Metal Np Arrays Using Dna Self-assembliessupporting

confidence: 53%

See 1 more Smart Citation

DNA nanostructures as scaffolds for metal nanoparticles

Kuzuya

Ohya

2012

Polym J

View full text Add to dashboard Cite

The rapid development of DNA nanotechnology has enabled the precise bottom-up integration of metal nanoparticles (NPs) on a nanometer scale. The recent introduction of the DNA origami technique has facilitated even more complicated control of the positioning of not only 2 dimensional (D) but also 3D structures. INTRODUCTIONAlthough top-down fabrications, such as photolithography and etching, have long driven advances in nanotechnology, they are now approaching their physical limits. Bottom-up fabrication techniques are expected to break through these limitations. However, these approaches cannot yet replace top-down techniques. Colloidal nanocrystals, including metals and semiconductors, exhibit distinctive properties not observed in the bulk state. Therefore, they are of particular interest for nanotechnology and nanoscience. For example, gold nanoparticles (AuNPs) exhibit unique optical and electrical properties, such as surface plasmon resonance. 1,2 On the basis of their distinctive properties, metal NPs have been applied for biological sensing, diagnosis and other applications. 3,4 Moreover, as new properties not observed in the distributed state are expected to emerge in the organized states, 5 the precise arrangement of metal NPs in 1 dimensional (D) to 3D is one of the important technical objectives of bottom-up nanotechnology. 6,7 On the other hand, DNA is the ideal building block for the construction of self-organized nanostructures. A strand of DNA can specifically bind with its complementary counter strand by WatsonCrick base pairing to form a B-type double helix, which is most common for a pair of complementary DNA in nature and almost independent of their sequences. This fact is highly convenient for fabricating universal nanostructures, as each double helix consisting of various sequences of DNA has the same diameter and pitch. On the basis of this fact and other advantages, such as sequence programmability, reversible double helix formation and strand exchange, availability by automatic synthesis, the relative rigidity of the double helix, enzymatic scission and ligation ability, and easy amplification by a PCR, many DNA-based approaches to construct highly ordered or well-designed nanostructures have been reported. [8][9][10]

show abstract

Section: Metal Np Arrays Using Dna Self-assembliessupporting

confidence: 53%

“…[16][17][18][19][20][21][22][23][24][25][26] Such DNA-based metal NP assemblies were also introduced in recent reviews. 10,16 2D periodic AuNP arrays were prepared using DNA nano-tiles as scaffolds.…”

Section: Metal Np Arrays Using Dna Self-assembliesmentioning

confidence: 99%

DNA nanostructures as scaffolds for metal nanoparticles

Kuzuya

Ohya

2012

Polym J

View full text Add to dashboard Cite

show abstract

“…In this way, molecules like oligonucleotides, peptides, or PEG can be readily linked to GNPs. [18][19][20] The advantage of physical adsorption is that the nanoparticles have a minimum effect on the structure and function of the biological molecule. With native structure intact, the activity, selectivity, and specificity of the biological molecule towards a particular target are largely unaffected.…”

Section: Modification With Biological Moleculesmentioning

confidence: 99%

“…This can give an exquisite level of control, as the polymerase chain reaction can be performed directly on the surface of GNPs for this kind of organization. 18 Any or all of these approaches may potentially be modified for gene or RNA stabilization and delivery as well, though remain to be tested. The possibilities for functionalization upon GNPs are vast.…”

mentioning

confidence: 99%

Functionalized gold nanoparticles for the binding, stabilization, and delivery of therapeutic DNA, RNA, and other biological macromolecules

DeLong¹,

Wanekaya²,

Reynolds³

et al. 2010

NSA

178

View full text Add to dashboard Cite

Nanotechnology has virtually exploded in the last few years with seemingly limitless opportunity across all segments of our society. If gene and RNA therapy are to ever realize their full potential, there is a great need for nanomaterials that can bind, stabilize, and deliver these macromolecular nucleic acids into human cells and tissues. Many researchers have turned to gold nanomaterials, as gold is thought to be relatively well tolerated in humans and provides an inert material upon which nucleic acids can attach. Here, we review the various strategies for associating macromolecular nucleic acids to the surface of gold nanoparticles (GNPs), the characterization chemistries involved, and the potential advantages of GNPs in terms of stabilization and delivery.

show abstract

“…In addition to these well-established applications, a new area that is emerging is plasmonics (Figure 3) 62,63 and especially chiroplasmonic assemblies and composites 64,65 . DNA-bridged NP assemblies can have a particularly essential role in the latter because they afford automatic assembly of such superstructres with exceptionally strong polarization rotation using PCR technique.…”

Section: What Are the Applications That Are Being Targeted And What Amentioning

confidence: 99%

Nanoparticle Assembly:A Perspective and some Unanswered Questions

et al. 2017

Self Cite

View full text Add to dashboard Cite

In early 2016, the Royal Society of Chemistry arranged a meeting on the topic 'NanoparticleKeywords: Function-driven design, fundamental issues, nanoparticle assembly, practical applications. NANOPARTICLE assemblies are encountered in a wide variety of practical applications. For example, over 70% of the approximately 12 million metric tonnes of carbon black nanoparticles (NPs) produced annually goes into rubber compounds used in automotive tyres 2,3 . Controlling carbon NP assembly in the nanocomposite is critical to the performance of the tyre and remains an active area of research. Spontaneous organization of the nanoscale platelets of clay into stacks and higher order structures is the key for balancing their mechanical performance and scalability 4 . Last but not the least, self-organization represent a quintessential biomimetic characteristic of inorganic NPs that leads to numerous implementations in drug delivery, biosensing, biotechnology and even agriculture. The use of colorimetric biosensors based on gold NP assembly is widespread (and growing), thanks to advances in the chemistry of coupling molecules to gold surfaces. Controlling the process of NP assembly and the resultant structure is critical to not only these uses, but also for applications in catalysis, in conversion of solar energy, and for creating materials with unique optical and optoelectronic properties. The assembly of NPs into chains followed by oriented attachment leads to lattice connectivity between initially separated inorganic grains 5,6 . This effect is essential for the energy storage devices 7,8 . What does 'control over NP assembly' entail

show abstract

Nanoparticle Superstructures Made by Polymerase Chain Reaction: Collective Interactions of Nanoparticles and a New Principle for Chiral Materials

Cited by 233 publications

References 57 publications

DNA nanostructures as scaffolds for metal nanoparticles

DNA nanostructures as scaffolds for metal nanoparticles

Functionalized gold nanoparticles for the binding, stabilization, and delivery of therapeutic DNA, RNA, and other biological macromolecules

Nanoparticle Assembly:A Perspective and some Unanswered Questions

Contact Info

Product

Resources

About