Nanoparticle size and chemical modification play a crucial role in the interaction of nano gold with the brain: extent of accumulation and toxicity

Mahmoud, Nouf N.; Albasha, Abdulrahim; Hikmat, Suhair; Hamadneh, Lama; Zaza, Rand; Shraideh, Z.; Khalil, Enam A.

doi:10.1039/c9bm02072a

Cited by 34 publications

(22 citation statements)

References 51 publications

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“…Nanoparticle aggregates behave as large particles, with different properties from individual nanoparticles and this can lead to immunogenic effects (Casals et al, 2017). The size of nanoparticles influences biodistribution, and generally smaller nanoparticles penetrate the CNS faster and with higher specificity than larger ones (Mahmoud et al, 2020). In addition to CNS penetration, nanoparticle properties also have an impact on cell targeting (Peviani et al, 2019).…”

Section: Nanoparticles For Drug Delivery To the Cnsmentioning

confidence: 99%

Neuroinflammation Treatment via Targeted Delivery of Nanoparticles

Cerqueira

Ayad

Lee

2020

Front. Cell. Neurosci.

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The lack of effective treatments for most neurological diseases has prompted the search for novel therapeutic options. Interestingly, neuroinflammation is emerging as a common feature to target in most CNS pathologies. Recent studies suggest that targeted delivery of small molecules to reduce neuroinflammation can be beneficial. However, suboptimal drug delivery to the CNS is a major barrier to modulate inflammation because neurotherapeutic compounds are currently being delivered systemically without spatial or temporal control. Emerging nanomaterial technologies are providing promising and superior tools to effectively access neuropathological tissue in a controlled manner. Here we highlight recent advances in nanomaterial technologies for drug delivery to the CNS. We propose that state-of-the-art nanoparticle drug delivery platforms can significantly impact local CNS bioavailability of pharmacological compounds and treat neurological diseases.

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Section: Nanoparticles For Drug Delivery To the Cnsmentioning

confidence: 99%

Neuroinflammation Treatment via Targeted Delivery of Nanoparticles

Cerqueira

Ayad

Lee

2020

Front. Cell. Neurosci.

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“…The enhanced ability of the rod-like NPs to cross the BBB might be ascribable to their curvature being smaller than that of sphere-like NPs, thereby increasing the tendency of nanorods to bind membrane receptors on the surfaces of CCECs (Figure 2B). Additionally, shorter GNRs show greater brain accumulation than longer GNRs; this finding may be attributed to long GNRs facing greater resistance from the intercellular fluid or cytoplasmic matrix when crossing the BBB 54 . In short, although determining specific parameters for the geometry of NPs with optimal BBB penetration performance might be difficult, we speculate that NPs with small curvature and appropriate aspect ratios may cross the BBB more efficiently than conventional spherical NPs.…”

Section: Shapementioning

confidence: 99%

Gold-based nanomaterials for the treatment of brain cancer

Luo

et al. 2021

Cancer Biol. Med.

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Brain cancer, also known as intracranial cancer, is one of the most invasive and fatal cancers affecting people of all ages. Despite the great advances in medical technology, improvements in transporting drugs into brain tissue have been limited by the challenge of crossing the blood-brain barrier (BBB). Fortunately, recent endeavors using gold-based nanomaterials (GBNs) have indicated the potential of these materials to cross the BBB. Therefore, GBNs might be an attractive therapeutic strategy against brain cancer. Herein, we aim to present a comprehensive summary of current understanding of the critical effects of the physicochemical properties and surface modifications of GBNs on BBB penetration for applications in brain cancer treatment. Furthermore, the most recent GBNs and their impressive performance in precise bioimaging and efficient inhibition of brain tumors are also summarized, with an emphasis on the mechanism of their effective BBB penetration. Finally, the challenges and future outlook in using GBNs for brain cancer treatment are discussed. We hope that this review will spark researchers' interest in constructing more powerful nanoplatforms for brain disease treatment.

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“…Functionalization the Au nanoparticles with 4‐mercaptophenol demonstrated the highest potential for the nanoparticles to cross the blood‐brain barrier without inducing extensive toxicity. [ 331 ]…”

Section: Toxicitymentioning

confidence: 99%

Nonspherical Metal‐Based Nanoarchitectures: Synthesis and Impact of Size, Shape, and Composition on Their Biological Activity

Zare

Zheng

Makvandi

et al. 2021

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Metal‐based nanoentities, apart from being indispensable research tools, have found extensive use in the industrial and biomedical arena. Because their biological impacts are governed by factors such as size, shape, and composition, such issues must be taken into account when these materials are incorporated into multi‐component ensembles for clinical applications. The size and shape (rods, wires, sheets, tubes, and cages) of metallic nanostructures influence cell viability by virtue of their varied geometry and physicochemical interactions with mammalian cell membranes. The anisotropic properties of nonspherical metal‐based nanoarchitectures render them exciting candidates for biomedical applications. Here, the size‐, shape‐, and composition‐dependent properties of nonspherical metal‐based nanoarchitectures are reviewed in the context of their potential applications in cancer diagnostics and therapeutics, as well as, in regenerative medicine. Strategies for the synthesis of nonspherical metal‐based nanoarchitectures and their cytotoxicity and immunological profiles are also comprehensively appraised.

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Nanoparticle size and chemical modification play a crucial role in the interaction of nano gold with the brain: extent of accumulation and toxicity

Abstract: Short Mph-GNR show high brain accumulation percentage, while long GNR show low brain accumulation and high delivery into other organs.

Cited by 34 publications

References 51 publications

Neuroinflammation Treatment via Targeted Delivery of Nanoparticles

Neuroinflammation Treatment via Targeted Delivery of Nanoparticles

Gold-based nanomaterials for the treatment of brain cancer

Nonspherical Metal‐Based Nanoarchitectures: Synthesis and Impact of Size, Shape, and Composition on Their Biological Activity

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