Neuroinflammation Treatment via Targeted Delivery of Nanoparticles

Cerqueira, Susana R.; Ayad, Nagi G.; Lee, Jae K.

doi:10.3389/fncel.2020.576037

Cited by 30 publications

(22 citation statements)

References 102 publications

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“…A large amount of NMs have been designed and manufactured for anti-neuroinflammation, including Au NPs, ZnO NPs [ 152 ], and CeO 2 NPs [ 8 ]. The anti-neuroinflammation mechanisms of these NMs have been summarized in many reviews [ 152 , 153 ], as follows: (1) By blocking the pro-inflammatory cytokine production, including IL-1, IL-6, and TNF-α. (2) By inhibiting the activation of microglia, which are the resident brain macrophage protecting the brain from external stimulation, and is the main source of neuroinflammation [ 154 ].…”

Section: Inhibiting Rons Generation Rather Than Scavenging Ronsmentioning

confidence: 99%

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Nanomaterials alleviating redox stress in neurological diseases: mechanisms and applications

et al. 2022

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Overproduced reactive oxygen and reactive nitrogen species (RONS) in the brain are involved in the pathogenesis of several neurological diseases, such as Alzheimer's disease, Parkinson's disease, traumatic brain injury, and stroke, as they attack neurons and glial cells, triggering cellular redox stress. Neutralizing RONS, and, thus, alleviating redox stress, can slow down or stop the progression of neurological diseases. Currently, an increasing number of studies are applying nanomaterials (NMs) with anti-redox activity and exploring the potential mechanisms involved in redox stress-related neurological diseases. In this review, we summarize the anti-redox mechanisms of NMs, including mimicking natural oxidoreductase activity and inhibiting RONS generation at the source. In addition, we propose several strategies to enhance the anti-redox ability of NMs and highlight the challenges that need to be resolved in their application. In-depth knowledge of the mechanisms and potential application of NMs in alleviating redox stress will help in the exploration of the therapeutic potential of anti-redox stress NMs in neurological diseases. Graphical Abstract

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Section: Inhibiting Rons Generation Rather Than Scavenging Ronsmentioning

confidence: 99%

“…Moreover, the survival rates and neurological outcomes of these animals models were improved [ 8 ]. (3) Some NMs without inherent anti-neuroinflammation can indirectly produce anti-neuroinflammation effects via delivering anti-inflammatory agents to the injured brain as a drug carrier [ 153 ].…”

Section: Inhibiting Rons Generation Rather Than Scavenging Ronsmentioning

confidence: 99%

Nanomaterials alleviating redox stress in neurological diseases: mechanisms and applications

et al. 2022

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“… 121 Applying nanoparticles to transport therapeutic substances enhances biodistribution and pharmacokinetics, permits co-delivery of several drugs, provides targeted intracellular drug delivery and decreases systemic toxicity/side effects. 122 …”

Section: Nanoformulations In Combating Neurodegeneration: Pre-clinical Evidencementioning

confidence: 99%

Nanoparticles in Combating Neuronal Dysregulated Signaling Pathways: Recent Approaches to the Nanoformulations of Phytochemicals and Synthetic Drugs Against Neurodegenerative Diseases

Fakhri¹,

Abdian²,

Zarneshan³

et al. 2022

IJN

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As the worldwide average life expectancy has grown, the prevalence of age-related neurodegenerative diseases (NDDs) has risen dramatically. A progressive loss of neuronal function characterizes NDDs, usually followed by neuronal death. Inflammation, apoptosis, oxidative stress, and protein misfolding are critical dysregulated signaling pathways that mainly orchestrate neuronal damage from a mechanistic point. Furthermore, in afflicted families with genetic anomalies, mutations and multiplications of α-synuclein and amyloid-related genes produce some kinds of NDDs. Overproduction of such proteins, and their excessive aggregation, have been proven in various models of neuronal malfunction and death. In this line, providing multi-target therapies carried by novel delivery systems would pave the road to control NDDs through simultaneous modulation of such dysregulated pathways. Phytochemicals are multi-target therapeutic agents, which employ several mechanisms towards neuroprotection. Besides, the blood–brain barrier (BBB) is a critical issue in managing NDDs since it inhibits the accessibility of drugs to the brain in sufficient concentration. Besides, discovering novel delivery systems is vital to improving the efficacy, bioavailability, and pharmacokinetic of therapeutic agents. Such novel formulations are also employed to improve the drug’s biodistribution, allow for the co-delivery of several medicines, and offer targeted intracellular delivery against NDDs. The present review proposes nanoformulations of phytochemicals and synthetic agents to combat NDDs by modulating neuroinflammation, neuroapoptosis, neuronal oxidative stress pathways and protein misfolding.

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“…Additionally, conjugation or encapsulation of active molecules like peptides and proteins protects this fragile cargo from premature clearance or degradation by harsh physiological conditions [ 107 , 108 ]. Of course, it is critically important to choose an appropriate biomaterial and drug cargo to achieve a desired stromal, stem cell, or immune cell outcome [ 10 , 109 , 110 , 111 ]. Therapies for immunomodulation often leverage known pro- or anti-inflammatory pathways for cancer therapy and regenerative medicine, respectively.…”

Section: Biomaterials Strategies To Modulate Immune Cell Phenotypesmentioning

confidence: 99%

Clickable Biomaterials for Modulating Neuroinflammation

Cornelison

Fadel

2022

IJMS

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Crosstalk between the nervous and immune systems in the context of trauma or disease can lead to a state of neuroinflammation or excessive recruitment and activation of peripheral and central immune cells. Neuroinflammation is an underlying and contributing factor to myriad neuropathologies including neurodegenerative diseases like Alzheimer’s disease and Parkinson’s disease; autoimmune diseases like multiple sclerosis; peripheral and central nervous system infections; and ischemic and traumatic neural injuries. Therapeutic modulation of immune cell function is an emerging strategy to quell neuroinflammation and promote tissue homeostasis and/or repair. One such branch of ‘immunomodulation’ leverages the versatility of biomaterials to regulate immune cell phenotypes through direct cell-material interactions or targeted release of therapeutic payloads. In this regard, a growing trend in biomaterial science is the functionalization of materials using chemistries that do not interfere with biological processes, so-called ‘click’ or bioorthogonal reactions. Bioorthogonal chemistries such as Michael-type additions, thiol-ene reactions, and Diels-Alder reactions are highly specific and can be used in the presence of live cells for material crosslinking, decoration, protein or cell targeting, and spatiotemporal modification. Hence, click-based biomaterials can be highly bioactive and instruct a variety of cellular functions, even within the context of neuroinflammation. This manuscript will review recent advances in the application of click-based biomaterials for treating neuroinflammation and promoting neural tissue repair.

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Neuroinflammation Treatment via Targeted Delivery of Nanoparticles

Cited by 30 publications

References 102 publications

Nanomaterials alleviating redox stress in neurological diseases: mechanisms and applications

Nanomaterials alleviating redox stress in neurological diseases: mechanisms and applications

Nanoparticles in Combating Neuronal Dysregulated Signaling Pathways: Recent Approaches to the Nanoformulations of Phytochemicals and Synthetic Drugs Against Neurodegenerative Diseases

Clickable Biomaterials for Modulating Neuroinflammation

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