Nanoparticle-Sensitized Photodegradation of Bilirubin and Potential Therapeutic Application

Sarkar, Soumik; Makhal, Abhinandan; Baruah, Sunandan; Mahmood, Mohammad Abbas; Dutta, Joydeep; Pal, Samir Kumar

doi:10.1021/jp301316e

Cited by 29 publications

(24 citation statements)

References 47 publications

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“…Hence, the photoproducts formed after the photocatalysis of BR in the presence of ZnO nanoparticles should mainly contain the structural ( Z -lumirubin) and configurational (( Z , E )-BR) isomers of water-insoluble BR, which are the usual photoproducts of the BR phototherapy [2]. In addition, the presence of methylvinylmaleimide (MVM) as an outcome of the photocatalytic degradation of BR in the presence of ZnO nanoparticles has also been evidenced in our previous study [15]. …”

Section: Resultsmentioning

confidence: 84%

“…Using picosecond-resolved spectroscopy techniques we have recently demonstrated that both singly charged (V O + ) and doubly charged (V O ++ ) oxygen vacancy centers contribute to the energy transfer process with efficiencies of about 78% and 89%, respectively [15]. In the present study, the average lifetime (τ avg ) of the fluorescence decay of the as-synthesized ZnO nanoparticles was found to be reduced by an order of magnitude upon the addition of BR, from 8.78 ns to 0.79 ns, with an energy transfer efficiency ( E ) of 91.53%.…”

Section: Resultsmentioning

confidence: 99%

“…In one of our recent studies, it was demonstrated that upon surface adsorption of BR molecules on ZnO nanostructures, a resonant defect-mediated energy transfer from the photo-excited ZnO nanostructures to the BR molecules induces their photodegradation [15]. It was also demonstrated that the system can effectively degrade BR when it is bound to albumin.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Modulation of defect-mediated energy transfer from ZnO nanoparticles for the photocatalytic degradation of bilirubin

Bora¹,

Lakshman²,

Sarkar³

et al. 2013

Beilstein J. Nanotechnol.

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SummaryIn recent years, nanotechnology has gained significant interest for applications in the medical field. In this regard, a utilization of the ZnO nanoparticles for the efficient degradation of bilirubin (BR) through photocatalysis was explored. BR is a water insoluble byproduct of the heme catabolism that can cause jaundice when its excretion is impaired. The photocatalytic degradation of BR activated by ZnO nanoparticles through a non-radiative energy transfer pathway can be influenced by the surface defect-states (mainly the oxygen vacancies) of the catalyst nanoparticles. These were modulated by applying a simple annealing in an oxygen-rich atmosphere. The mechanism of the energy transfer process between the ZnO nanoparticles and the BR molecules adsorbed at the surface was studied by using steady-state and picosecond-resolved fluorescence spectroscopy. A correlation of photocatalytic degradation and time-correlated single photon counting studies revealed that the defect-engineered ZnO nanoparticles that were obtained through post-annealing treatments led to an efficient decomposition of BR molecules that was enabled by Förster resonance energy transfer.

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Section: Resultsmentioning

confidence: 84%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Modulation of defect-mediated energy transfer from ZnO nanoparticles for the photocatalytic degradation of bilirubin

Bora¹,

Lakshman²,

Sarkar³

et al. 2013

Beilstein J. Nanotechnol.

Self Cite

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“…Figure 3 a shows a prototype photodevice for investigation of the photocatalytic efficiency of the nanohybrid under visible‐light irradiation. Full details of the device may be found in our earlier publication 26. The test water under investigation contained methylene blue (MB), a model water contaminant, in the absence and presence of iron and copper cations (44.5 mg L −1 copper and 39.2 mg L −1 iron).…”

Section: Resultsmentioning

confidence: 99%

Impact of Metal Ions in Porphyrin‐Based Applied Materials for Visible‐Light Photocatalysis: Key Information from Ultrafast Electronic Spectroscopy

Kar

Sardar

Alarousu

et al. 2014

Chemistry A European J

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Protoporphyrin IX-zinc oxide (PP-ZnO) nanohybrids have been synthesized for applications in photocatalytic devices. High-resolution transmission electron microscopy (HRTEM), X-ray diffraction (XRD), and steady-state infrared, absorption, and emission spectroscopies have been used to analyze the structural details and optical properties of these nanohybrids. Time-resolved fluorescence and transient absorption techniques have been applied to study the ultrafast dynamic events that are key to photocatalytic activities. The photocatalytic efficiency under visible-light irradiation in the presence of naturally abundant iron(III) and copper(II) ions has been found to be significantly retarded in the former case, but enhanced in the latter case. More importantly, femtosecond (fs) transient absorption data have clearly demonstrated that the residence of photoexcited electrons from the sensitizer PP in the centrally located iron moiety hinders ground-state bleach recovery of the sensitizer, affecting the overall photocatalytic rate of the nanohybrid. The presence of copper(II) ions, on the other hand, offers additional stability against photobleaching and eventually enhances the efficiency of photocatalysis. In addition, we have also explored the role of UV light in the efficiency of photocatalysis and have rationalized our observations from femtosecond- to picosecond-resolved studies.

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“…They have good stability and are capable of being used as a diagnostic tool in cancer diagnosis and therapy 8. Globally, a lot of research is underway to explore their potential candidacy as drug delivery tool and behavior toward biological systems 9–14…”

Section: Introductionmentioning

confidence: 99%

<p>Effect of commercial and green synthesized ZnO NPs in murine model of chloroquine-induced pruritus</p>

Aman¹,

Rauf²,

Khan³

et al. 2019

IJN

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Purpose: To investigate the effects of zinc oxide nanoparticles (ZnO NPs) on chloroquine (CQ)-induced itching, and overall behavior of mice after oral administration of ZnO NPs of various sizes and doses. Background: With the wide-spread use of ZnO NPs in pharmaceuticals and cosmetics, concerns about their safety and toxicity are also increasing. Multiple aspects of ZnO NPs regarding cytotoxicity and tolerability are under investigation globally. Still, a clear conclusion about their safety has not been reached. Chloroquine phosphate is an antimalarial with known side effects of itching in humans and animals. In this study, CQ was used to induce itching in mice, and the effects of ZnO NPs on scratching and other neurological behavior of mice were observed. Methods: Female BALB/c mice were divided into eleven groups of six mice each. ZnO NPs of various sizes and doses were administered orally 1 hour before CQ (32 mg/kg body weight) was administered subcutaneously. The effect of ZnO NPs on CQ-induced pruritus was observed for the next 30 minutes. Simultaneously, overall behavioral changes (socialization and locomotion) were also recorded using a video camera. Results: A significant reduction ( P ˂0.001) in scratching bouts was observed at all three doses of ZnO NPs (particle sizes 100, 30 nm, and green synthesized 30 nm). Locomotion was reduced significantly ( P ˂0.001) in ZnO NPs-treated groups in comparison to normal saline and CQ group, additionally, a significant increase in socialization ( P ˂0.05) was observed in ZnO NP-treated groups as compared to CQ group. Conclusion: ZnO NPs, instead of aggravating the dermatological condition, ameliorated the pruritus. All sizes of ZnO NPs used significantly improved socialization among mice and reduced locomotion activity.

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Nanoparticle-Sensitized Photodegradation of Bilirubin and Potential Therapeutic Application

Cited by 29 publications

References 47 publications

Modulation of defect-mediated energy transfer from ZnO nanoparticles for the photocatalytic degradation of bilirubin

Modulation of defect-mediated energy transfer from ZnO nanoparticles for the photocatalytic degradation of bilirubin

Impact of Metal Ions in Porphyrin‐Based Applied Materials for Visible‐Light Photocatalysis: Key Information from Ultrafast Electronic Spectroscopy

<p>Effect of commercial and green synthesized ZnO NPs in murine model of chloroquine-induced pruritus</p>

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