Nanoparticle-mediated singlet oxygen generation from photosensitizers

Light-triggered liposomal cargo delivery platform incorporating photosensitizers and gold nanoparticles for enhanced singlet oxygen generation and increased cytotoxicity

“…33,34 Similarly, in our previous research on gold-RB conjugates, we also observed the enhancement of 1 O 2 formation when excited at 532 nm compared with RB alone. 32 Liposomes with a molar ratio (HSPC:PE-NH 2 :gold) of 57:5:8.5 exhibited a relatively efficient 1 O 2 generation with an enhancement factor of 1.53 compared with the liposomes containing RB alone. However, no additional enhancement was observed when increasing the amount of gold nanoparticles (HSPC:PE-NH 2 :gold =57:5:34) at the same experimental conditions (Figure 2).…”

Combination Strategies for Targeted Delivery of Nanoparticles for Cancer Therapy

“…Nanoparticles are also promising carriers for PSs, as they can be designed to provide excellent biocompatibility, improve the stability, increase the efficiency of delivery to targeted tissues, overcome the blood-brain barrier (BBB) (Dixit et al 2015) or cell-membrane transporters (Roh et al 2017), and to enhance the generation of singlet oxygen by PSs. (Clement et al 2017;Kautzka et al 2017) For instance, Ting Yin et al assembled Fe3O4@polymer-NPO/PEG-Glc@Ce6 nanoprobes which have prolonged residence time in tumour tissue and reduced accumulation in the normal organs, due to their targeting ability, ultra-small size and high stability (Yin et al 2017). Polymeric nanoparticles are capable of adsorbing on cell surfaces and accumulate in cells due to cellular uptake mechanisms.…”

“…Roh et al reported that polymeric nanoparticles can be used to encapsulate Chlorin-based photosensitizers, another drug commonly used in PDT, to overcome the efflux by cell-membrane transporters and increase the intracellular concentration of the PS (Roh et al 2017). The conjugation of VP and RB to CeF3 and gold nanoparticles has been proven increase the efficiency of singlet oxygen generation by PSs (Clement et al 2017). Gold nanoparticles were also found to enhance the generation of singlet oxygen while encapsulated in light-triggered liposomes containing RB.…”

“…Nanoplatforms allow more accurate, non-invasive and real-time cancer diagnosis and monitoring during therapy using magnetic resonance imaging, ultrasonography, etc. (Alexis et al 2008;Baetke et al 2015;Zaimy et al 2017) Adjuvant nanotechnological devices are used in cancer interventions such as radiotherapy (Wu et al 2016), photodynamic therapy (Clement et al 2017) and sonodynamic therapy (Xu et al 2016), which are capable of achieving considerably higher precision of treatment and reduced side effects. After decades of developing the understanding of nanotechnology, cancerrelated nano-treatments have undergone extensive preclinical and clinical-trial studies and shown promising results (H. .…”

Curcuma Longa Extract as a Sensitizer for Singlet Oxygen Generation

“…The process of interaction of the triplet states of the sensitizer with triplet oxygen causes a number of chemical processes and leads to the formation of reactive oxygen species [3,4].…”