Combination Strategies for Targeted Delivery of Nanoparticles for Cancer Therapy

He, Zhonglei; Liu, Kangze; Byrne, Hugh J.; Cullen, Patrick J.; Tian, Furong; Curtin, James F.

doi:10.1016/b978-0-12-814029-1.00008-9

Cited by 10 publications

(8 citation statements)

References 190 publications

(263 reference statements)

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“…Their platforms have attracted considerable attention from academic and clinical areas and have become the most studied biomaterial nanoparticles due to the fact that they can improve the efficiency of a drug by increasing its solubility, overcoming resistance, controlling its targeted release, and modifying its biocompatibility, bioavailability, and safety profile [128].…”

Section: Polymersomes and Liposomesmentioning

confidence: 99%

Polymers and Polymer Nanocomposites for Cancer Therapy

Feldman

2019

Applied Sciences

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Synthetic polymers, biopolymers, and their nanocomposites are being studied, and some of them are already used in different medical areas. Among the synthetic ones that can be mentioned are polyolefins, fluorinated polymers, polyesters, silicones, and others. Biopolymers such as polysaccharides (chitosan, hyaluronic acid, starch, cellulose, alginates) and proteins (silk, fibroin) have also become widely used and investigated for applications in medicine. Besides synthetic polymers and biopolymers, their nanocomposites, which are hybrids formed by a macromolecular matrix and a nanofiller (mineral or organic), have attracted great attention in the last decades in medicine and in other fields due to their outstanding properties. This review covers studies done recently using the polymers, biopolymers, nanocomposites, polymer micelles, nanomicelles, polymer hydrogels, nanogels, polymersomes, and liposomes used in medicine as drugs or drug carriers for cancer therapy and underlines their responses to internal and external stimuli able to make them more active and efficient. They are able to replace conventional cancer drug carriers, with better results. Appl. Sci. 2019, 9, 3899 2 of 24 nanocomposites offer numerous opportunities in diverse applications, including nanocarriers, tissue engineering, antimicrobials, sensors, etc. These new groups of materials have gained significant research interest due to their novel properties, which are gained through the addition of nanofillers. Polymer nanocomposites have significant potential in disease theranostics, and nanotechnology brings great promise in cancer drug carriers [4].Chemotherapy implies the use of drugs and, besides the drugs, carriers. Common products used as carriers include synthetic polymers, biopolymers, and polymer nanocomposites.Some of the most useful drugs for chemotherapy are toxic chemicals able to inhibit the proliferation of cancer cells. The use of chemotherapeutic drugs has been in part hindered by their poor solubility in water, their short biological half-life, their lack of targeting ability, and the development of multidrug resistance [5]. In the last decades, nanoparticles have shown significant promise as an oncology treatment modality. Responsive polymers represent a promising class of nanoparticles that can trigger delivery through the exploitation of a specific stimuli. Response to a stimulus is one of the most basic processes found in living systems. A tutorial review highlighted the recent developments in polymer-based approaches to internally responsive nanoparticles for oncology [6].One important goal of medicine is to develop carriers that can selectively deliver anticancer drugs to tumor cells with no or minimal side effects in healthy cells [7,8].Polymers and their nanocomposites in different forms, such as micelles, hydrogels, polymersomes, and liposomes, have important potential in cancer diagnosis and treatment.Nanocomposites are popular in many areas due to properties such as their unique design capacity, eco-friendly nature, ...

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Section: Polymersomes and Liposomesmentioning

confidence: 99%

Polymers and Polymer Nanocomposites for Cancer Therapy

Feldman

2019

Applied Sciences

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“…Moreover, the BBB limits the delivery of contrast and therapeutic agents to the GBM. Nanoparticles can be used not only as drug carriers but also as sensitizers and imaging agents in cancer treatments (He et al, 2019). These multifunctional hybrid nanoparticles could be applied in laser-assisted therapies (photodynamic (PDT), photothermal (PTT) and photoacoustic (PAT), and in different imaging techniques such as computed tomography (CT), magnetic particle imaging (MPI), MRI, positron emission tomography (PET), and single photon emission computed tomography (SPECT) (Nabil et al, 2018)).…”

Section: Theranostic Applications Of Multifunctional Nanoparticles In Gliomamentioning

confidence: 99%

Immunoengineering in glioblastoma imaging and therapy

Zanganeh

Georgala

Corbo

et al. 2019

WIREs Nanomed Nanobiotechnol

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Patients diagnosed with glioblastoma have poor prognosis. Conventional treatment strategies such as surgery, chemotherapy, and radiation therapy demonstrated limited clinical success and have considerable side effects on healthy tissues. A central challenge in treating brain tumors is the poor permeability of the blood–brain barrier (BBB) to therapeutics. Recently, various methods based on immunotherapy and nanotechnology have demonstrated potential in addressing these obstacles by enabling precise targeting of brain tumors to minimize adverse effects, while increasing targeted drug delivery across the BBB. In addition to treating the tumors, these approaches may be used in conjunction with imaging modalities, such as magnetic resonance imaging and positron emission tomography to enhance the prognosis procedures. This review aims to provide mechanistic understanding of immune system regulation in the central nervous system and the benefits of nanoparticles in the prognosis of brain tumors. This article is characterized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging Nanotechnology Approaches to Biology > Cells at the Nanoscale Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

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“…Currently, diverse research groups have aimed to design nano-DDSs to improve and guarantee a major degree of drug delivery efficiency [ 132 , 133 , 248 ]. For this purpose, researchers can arrange diverse predesigned organic and inorganic functional molecules to form different nanostructures and identify superior results [ 249 , 250 ]. This type of nanostructure is dominated by supramolecular chemistry interactions including self-assembly, hydrogen bonding, van der Waals forces, dipole–dipole interactions, hydrophobic interactions, and so forth [ 251 ].…”

Section: Carbon Dot–silica Nanoparticle Synthesis and Applicationsmentioning

confidence: 99%

A Brief Review of Carbon Dots–Silica Nanoparticles Synthesis and their Potential Use as Biosensing and Theragnostic Applications

Ornelas-Hernández¹,

Garduno-Robles²,

Zepeda‐Moreno

2022

Nanoscale Res Lett

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Carbon dots (CDs) are carbon nanoparticles with sizes below 10 nm and have attracted attention due to their relatively low toxicity, great biocompatibility, water solubility, facile synthesis, and exceptional photoluminescence properties. Accordingly, CDs have been widely exploited in different sensing and biomedical applications, for example, metal sensing, catalysis, biosensing, bioimaging, drug and gene delivery, and theragnostic applications. Similarly, the well-known properties of silica, such as facile surface functionalization, good biocompatibility, high surface area, and tunable pore volume, have allowed the loading of diverse inorganic and organic moieties and nanoparticles, creating complex hybrid nanostructures that exploit distinct properties (optical, magnetic, metallic, mesoporous, etc.) for sensing, biosensing, bioimaging, diagnosis, and gene and drug delivery. In this context, CDs have been successfully grafted into diverse silica nanostructures through various synthesis methods (e.g., solgel chemistry, inverse microemulsion, surfactant templating, and molecular imprinting technology (MIT)), imparting hybrid nanostructures with multimodal properties for distinct objectives. This review discusses the recently employed synthesis methods for CDs and silica nanoparticles and their typical applications. Then, we focus on combined synthesis techniques of CD–silica nanostructures and their promising biosensing operations. Finally, we overview the most recent potential applications of these materials as innovative smart hybrid nanocarriers and theragnostic agents for the nanomedical field. Graphical abstract

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Combination Strategies for Targeted Delivery of Nanoparticles for Cancer Therapy

Cited by 10 publications

References 190 publications

Polymers and Polymer Nanocomposites for Cancer Therapy

Polymers and Polymer Nanocomposites for Cancer Therapy

Immunoengineering in glioblastoma imaging and therapy

A Brief Review of Carbon Dots–Silica Nanoparticles Synthesis and their Potential Use as Biosensing and Theragnostic Applications

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