Nanoparticle drug delivery systems: an excellent carrier for tumor peptide vaccines

Abstract

In the past 40 years, the nanoparticle drug delivery system for tumor peptide vaccines has been widely studied which also reached a splendid result. Nanomaterial can enhance the targeting of vaccines, help vaccines enter the cells and trigger immune response by themselves. They also help in increasing cellular uptake, improving permeability and efficacy. Currently, several categories of nanopreparation, such as liposome, polymeric micelle, polymeric nanoparticle, gold nanoparticle and so on, are proved that they are appropriate for peptide vaccines. This review we discussed the possible mechanisms of nanomaterial’s action on the regulation of immunological functions and several major applications of this advanced drug delivery system for tumor peptide vaccine.

Emulsion Techniques for the Production of Pharmacological Nanoparticles

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Ultrafine Nanoparticles of Poly(Methyl Methacrylate-co-Methacrylic Acid) Loaded with Aspirin

“…The main expected advantages of this type of nanosystems with respect to the use of the free drug are claimed to be an increased efficiency, longer circulation time in the bloodstream, protection against degradation, and specifically in antineoplastic therapy, attenuation of side effects and overcoming of multidrug resistance [1][2][3][4]. Recently, an increased attention has been devoted to the research of polymeric nanoparticles as vehicle for immunotherapy [5] and photothermal therapy [6].…”

Colorectal cancer stem cells: a review of targeted drug delivery by gold nanoparticles

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