Nanoparticle–DNA–polymer composites for hepatocellular carcinoma cell labeling, sensing, and magnetic resonance imaging

Leung, Ken Cham‐Fai; Lee, Siu Fung; Wong, Chi Hin; Chak, Chun Pong; Lai, Josie M.Y.; Zhu, Xiao; Wáng, Yì Xiáng J.; Sham, Kathy W.Y.; Chen, Cheng

doi:10.1016/j.ymeth.2013.06.006

Cited by 12 publications

(5 citation statements)

References 42 publications

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“…Such agents are currently under clinical evaluation. [1] Key clinical trials for transcatheter arterial therapy for liver cancer [2][3][4][5] and the recent patents relevant to cancer chemoembolization are being developed. Herein, we describe the use of a hybrid nanoshell/drug/ polymer composite as a chemoembolization agent for transarterial delivery in liver tumors.…”

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confidence: 99%

In Vivo Chemoembolization and Magnetic Resonance Imaging of Liver Tumors by Using Iron Oxide Nanoshell/Doxorubicin/Poly(vinyl alcohol) Hybrid Composites

et al. 2014

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A hybrid composite made up of superparamagnetic iron oxide nanoshells encapsulating the anticancer drug doxorubicin and bound together by poly(vinyl alcohol) was developed. Transcatheter arterial delivery in an in vivo liver tumor model led to embolization of the liver tumor blood vessels. Embolization was followed by disassembly of the composite. The nanoshells were then able to pass through the leaky tumor vasculature into the tumor tissue, thereby leading to slow and sustained release of the drug. As well as being relatively noncytotoxic, the composite was responsive to magnetic resonance imaging, thus making it a potentially useful theranostic agent.

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confidence: 99%

In Vivo Chemoembolization and Magnetic Resonance Imaging of Liver Tumors by Using Iron Oxide Nanoshell/Doxorubicin/Poly(vinyl alcohol) Hybrid Composites

et al. 2014

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“…Their intrinsic properties as probes for various imaging techniques had also been developed rapidly for targeted brain cancer diagnosis and treatment [ 5 , 6 , 7 ]. Ultrasmall iron oxide nanoparticles (USIO NPs), by way of examples, offered properties including Fenton reactions [ 8 ], magnetic resonance imaging (MRI), magnetic targeting, cellular tracking, drug, and gene delivery to specific target site(s) [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. On the other hand, polyethylenimine (PEI) polymers with branched structures had been investigating their properties to deliver genes and drugs with enhanced transfection and targeting efficiencies as well as with minimal cytotoxicities [ 19 , 20 , 21 , 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Citrate-Coated Magnetic Polyethyleneimine Composites for Plasmid DNA Delivery into Glioblastoma

et al. 2021

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Several ternary composites that are based on branched polyethyleneimine (bPEI 25 kDa, polydispersity 2.5, 0.1 or 0.2 ng), citrate-coated ultrasmall superparamagnetic iron oxide nanoparticles (citrate-NPs, 8–10 nm, 0.1, 1.0, or 2.5 µg), and reporter circular plasmid DNA pEGFP-C1 or pRL-CMV (pDNA 0.5 µg) were studied for optimization of the best composite for transfection into glioblastoma U87MG or U138MG cells. The efficiency in terms of citrate-NP and plasmid DNA gene delivery with the ternary composites could be altered by tuning the bPEI/citrate-NP ratios in the polymer composites, which were characterized by Prussian blue staining, in vitro magnetic resonance imaging as well as green fluorescence protein and luciferase expression. Among the composites prepared, 0.2 ng bPEI/0.5 μg pDNA/1.0 µg citrate-NP ternary composite possessed the best cellular uptake efficiency. Composite comprising 0.1 ng bPEI/0.5 μg pDNA/0.1 μg citrate-NP gave the optimal efficiency for the cellular uptake of the two plasmid DNAs to the nucleus. The best working bPEI concentration range should not exceed 0.2 ng/well to achieve a relatively low cytotoxicity.

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“…Furthermore, the interface between nanotechnology, drug delivery, and magnetic resonance imaging (MRI) invites novel approaches to the diagnosis and treatment of diseases. Considerable interest has been devoted recently to the design of new hybrid magnetic NP‐based drug delivery systems for specifically targeted drug delivery to specific cells, lesion sites, and particularly tumor sites, from which the drug release can be modulated at a controlled rate and at the desired time . The main objective of targeted, site‐specific drug delivery or photodynamic therapy is to minimize the undesirable side effects of the active drugs on normal cells, with an increased local concentration of drugs at the lesion site.…”

Section: Introductionmentioning

confidence: 99%

Noble Metal-Iron Oxide Hybrid Nanomaterials: Emerging Applications

Leung

Xuan

2016

The Chemical Record

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This account provides an overview of current research activities that focus on the synthesis and applications of nanomaterials from noble metal (e.g., Au, Ag, Pd) and iron oxide (Fe3O4) hybrids. An introduction to the synthetic strategies that have been developed for generating M-Fe3O4 nanomaterials with different novel structures is presented. Surface functionalization and bioconjugation of these hybrid nanoparticles and nanocomposites are also reviewed. The utilization of the advantageous properties of both noble metals and iron oxide for a variety of applications, such as theranostics, gene delivery, biosensing, cell sorting, bioseparation, and catalysis, is discussed and highlighted. Finally, future trends and perspectives of these sophisticated nanocomposites are outlined. The fundamental requirements underpinning the effective preparation of M-Fex Oy hybrid nanomaterials shed light on the future development of heterogeneous catalysts, nanotheranostics, nanomedicines, and other chemical technologies.

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Nanoparticle–DNA–polymer composites for hepatocellular carcinoma cell labeling, sensing, and magnetic resonance imaging

Cited by 12 publications

References 42 publications

In Vivo Chemoembolization and Magnetic Resonance Imaging of Liver Tumors by Using Iron Oxide Nanoshell/Doxorubicin/Poly(vinyl alcohol) Hybrid Composites

In Vivo Chemoembolization and Magnetic Resonance Imaging of Liver Tumors by Using Iron Oxide Nanoshell/Doxorubicin/Poly(vinyl alcohol) Hybrid Composites

Citrate-Coated Magnetic Polyethyleneimine Composites for Plasmid DNA Delivery into Glioblastoma

Noble Metal-Iron Oxide Hybrid Nanomaterials: Emerging Applications

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