Nanoparticle-Based Wound Dressing: Recent Progress in the Detection and Therapy of Bacterial Infections

Abstract

Bacterial infections in wounds often delay the healing process, and may seriously threaten human life. It is urgent to develop wound dressings to effectively detect and treat bacterial infections. Nanoparticles have been extensively used in wound dressings because of their specific properties. This review highlights the recent progress on nanoparticle-based wound dressings for bacterial detection and therapy. Specifically, nanoparticles have been applied as intrinsic antibacterial agents or drug delivery vehicles to treat bacteria in wounds. Moreover, nanoparticles with photothermal or photodynamic property have also been explored to endow wound dressings with significant optical properties to further enhance their bactericidal effect. More interestingly, nanoparticle-based smart dressings have been recently explored for bacteria detection and treatment, which enables an accurate assessment of bacterial infection and a more precise control of on-demand therapy.

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

“…They employed PTDBD as a photo-initiator, β-glycerophosphate as a sol-gel conversion agent, and chitosan as scaffold material to obtain a visual antibacterial hydrogel. After 8 min of NIR irradiation, the temperature of the hydrogel up to 55 °C and showed a strong destructive effect on S. aureus [ 145 , 146 ].…”

Higher pulse frequency of near-infrared laser irradiation increases penetration depth for novel biomedical applications

“…A significant contribution/application of laser medicine is Photodynamic therapy (PDT) which uses light and a chemical substance called photosensitizer (PS) to generate molecular oxygen and elicit cell death. This phenomenon of phototoxicity has been a promising development with various applications in microbial detection and treatment of infections [1,2] involving even antibiotic resistant bacteria [3], enhanced wound healing [4] and cancer therapy [5]. As a clinically approved minimally invasive therapeutic procedure PDT exerts a selective cytotoxic activity toward malignant cells with demonstrated effectivity in cancers [6,7]-of the skin, head and neck, digestive system [8], urinary system [9], lungs, etc.…”

Synergic Influence of Parameters Involved in the Polymeric Nanoparticle Preparation on the Efficacy of Photodynamic Therapy

“…Photodynamic therapy (PDT) is an important therapeutic modality used in the treatment of cancer and several non-malignant diseases, including infections and dental treatments. [1][2][3][4][5] It is characterized by the administration of a photosensitizer (PS), a light source to activate it and oxygen molecules (Figure 1). [6] After administration of the photosensitizer, the diseased tissue is irradiated Photodynamic Therapy -From Basic Science to Clinical Research with visible light, causing the excitation of the PS to a singlet electronic state (S 1 ), which can be deactivated to the fundamental state (S 0 ) through radiative processes (fluorescence or phosphorescence) or non-radioactive (internal conversion, intersystem crossing or vibrational relaxation).…”

“…[15] PDT mechanism involving the combination of a photosensitizer, a light source and oxygen molecules. After excitation to a higher energy state (1), the photosensitizer may suffer rotovibrational decays to the excited state S 1 (2), from which the photosensitizer can suffer energy decay to the fundamental state S 0 , via fluorescence (3), intersystem crossing (4) or phosphorescence (5).…”