Nanoparticle-Based Therapeutic Approach for Diabetic Wound Healing

Abstract

Diabetes mellitus (DM) is a common endocrine disease characterized by a state of hyperglycemia (higher level of glucose in the blood than usual). DM and its complications can lead to diabetic foot ulcer (DFU). DFU is associated with impaired wound healing, due to inappropriate cellular and cytokines response, infection, poor vascularization, and neuropathy. Effective therapeutic strategies for the management of impaired wound could be attained through a better insight of molecular mechanism and pathophysiology of diabetic wound healing. Nanotherapeutics-based agents engineered within 1–100 nm levels, which include nanoparticles and nanoscaffolds, are recent promising treatment strategies for accelerating diabetic wound healing. Nanoparticles are smaller in size and have high surface area to volume ratio that increases the likelihood of biological interaction and penetration at wound site. They are ideal for topical delivery of drugs in a sustained manner, eliciting cell-to-cell interactions, cell proliferation, vascularization, cell signaling, and elaboration of biomolecules necessary for effective wound healing. Furthermore, nanoparticles have the ability to deliver one or more therapeutic drug molecules, such as growth factors, nucleic acids, antibiotics, and antioxidants, which can be released in a sustained manner within the target tissue. This review focuses on recent approaches in the development of nanoparticle-based therapeutics for enhancing diabetic wound healing.

<p>Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing</p>

“…Currently, there are some technologies of wound healing treatment for diabetes, namely topical drug treatment (eg, drugs, peptides and growth factors), cellular therapies (eg, stem cells and fibroblasts) and biomaterial-based treatment. 39 Biomaterials with controlled-release of signaling molecules can be combined with other therapeutic methods, which is a promising treatment method for diabetic wound healing. 40 In this review, we will summarize biomaterials and their potential applications in diabetic wound repair.…”

Düşük Dozda N-Asetilsistein Uygulaması Diyabetik Yara İyileşmesini Hızlandırır mı?

“…It has been reported that oxidative stress, which is known to be increased in diabetic wound healing, may lead to a stronger inflammatory response or a longer-lasting inflammatory phase (Luc et al, 2017;Cano-Sanchez et al, 2018;Kim et al, 2019). However, a reduction in, or impaired activity of, antioxidant molecules may also be the cause of impaired wound healing in diabetes (Ezhilarasu et al, 2020). NAC is an acetylated cysteine derivative that can help to protect cells against oxidative damage, and has been shown to modulate oxidative stress and inflammation in several ways (Janeczek et al, 2019).…”

MRI-traceable theranostic nanoparticles for targeted cancer treatment

“…The integration of nanotechnology and targeted drug delivery has opened potential avenues to achieve this goal. With high surface area to volume ratios and unique physiochemical properties, the architecture of nanoparticles allows optimization for the delivery of various imaging and therapeutic agents 4 .…”