Nanoparticle-Based Targeted Therapeutics in Head-And-Neck Cancer

Wu, Tingting; Zhou, Shui‐Hong

doi:10.7150/ijms.10083

Cited by 52 publications

(43 citation statements)

References 165 publications

(163 reference statements)

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“…Moreover, the systemic administration of anticancer agents produces generalized or organ-specific toxicity in the patients. As a result, a cancer-targeted delivery system is urgently needed [11,14].…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Gold Nanoshell-Loaded Macrophage for Photothermal Biomedicine

Kang

Lee

Park

et al. 2020

BioMed Research International

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The purpose of this study was to investigate the effect of photothermal treatment (PTT) with gold nanoshell (ANS) using a macrophage-mediated delivery system in a head and neck squamous cell carcinoma (HNSCC) cell line. To achieve this, ANSloaded rat macrophages (ANS-MAs) were prepared via the coculture method with ANS. The human HNSCC (FaDu cell) and macrophage (rat macrophage; NR8383 cell) hybrid spheroid models were generated by the centrifugation method to determine the possibility of using ANS-MAs as a cancer therapy. These ANS-MAs were set into the tumor and macrophage hybrid spheroid model to measure PTT efficacy. Kinetic analysis of the spheroid growth pattern revealed that this PTT process caused a decreasing pattern in the volume of the hybrid model containing ANS-MAs (p < 0:001). Comparison with empty macrophages showed harmony between ANS and laser irradiation for the generation of PTT. An annexin V/dead cell marker assay indicated that the PTT-treated hybrid model induced increasing apoptosis and dead cells. Further studies on the toxicity of ANS-MAs are needed to reveal whether it can be considered biocompatible. In summary, the ANS was prepared with a macrophage as the delivery method and protective carrier. The ANS was successfully localized to the macrophages, and their photoabsorption property was stationary. This strategy showed significant growth inhibition of the tumor and macrophage spheroid model under NIR laser irradiation. In vivo toxicology results suggest that ANS-MA is a promising candidate for a biocompatible strategy to overcome the limitations of fabricated nanomaterials. This ANS-MA delivery and PTT strategy may potentially lead to improvements in the quality of life of patients with HNSCC by providing a biocompatible, minimally invasive modality for cancer treatment.

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Section: Introductionmentioning

confidence: 99%

Biomimetic Gold Nanoshell-Loaded Macrophage for Photothermal Biomedicine

Kang

Lee

Park

et al. 2020

BioMed Research International

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“…Head-and-neck cancer is ranked amongst the most fatal cancers owing to its poor prognosis. Squamous cell carcinoma of the head and neck (HNSCC) proliferates at the brink of oral cavity, paranasal sinuses and nasal cavity along with larynx and pharynx, and contributes to nearly 900,000 new cases and 350,000 mortalities annually worldwide [1]. Paclitaxel (PTX) is one of the most valued anticancer drugs for the treatment of breast, colon, prostate, melanoma and various types of solid cancers [2].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of clinical effectiveness of paclitaxel and ursolic acid co-loaded liposomes as enhanced treatment for head and neck squamous cell carcinoma

Lv¹,

Tan²,

Shang³

et al. 2019

Trop. J. Pharm Res

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Purpose: To enhance the clinical effectiveness of paclitaxel (PTX) by co-delivery with ursolic acid (UA) for the treatment of head and neck cancer Methods: Co-loaded liposomes of PTX and UA (UA-PTX-LiP) were prepared by thin-film hydration method. Their size and loading efficiency were determined using dynamic light scattering (DLS) technique and high performance liquid chromatography (HPLC), respectively. The effectiveness of UA-PTX-LiP against HSC-3 human head and neck cancer cell-lines was compared with that of PTX liposome (PTX-LiP) using systemic cell-based in vitro evaluation with MTT assay. Fluorescent microscopy was used for cell uptake studies. Results: The size of the prepared UA-PTX-LiP was 126.5 ± 3.22 nm. The ratiometric system for PTX and UA as liposomes revealed significantly enhanced cytotoxicity, with comparatively lower IC50, when compared to individual PTX-Lip. Fluorescent microscopy revealed the internalization ability of UA-PTX-LiP by targeted delivery of PTX in HSC-3 human head and neck cancer cell-line. Conclusion: These results show that UA-PTX-LiP successfully enhances the therapeutic potential and clinical outcomes of PTX in head-and-neck cancer, and also demonstrate the useful effect of combination of UA and PTX in chemotherapy.

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“…Recent studies on miRNA-SNP have shown a significant correlation between miRNA and progression of ischemic disease, which defines miRNA as potential biomarker and diagnostic and delivery. Tissues from organs such as kidney, liver, spleen, and lung are more easily accessible than from other organs, which provide sufficient delivery by antisense oligonucleotides without using carriers, whereas chemically formulated carrier molecule is needed to deliver ASOs in solid tumors (151). It has been shown that overexpression of miR17-92, a highly induced miRNA in solid tumors and hematological malignancies, increases cell proliferation and suppression of apoptosis by affecting the BCL-2 interacting mediator, phosphatase, and tensing homologue and expression of the p21 gene (152,153).…”

Section: Micrornas: Potential Therapeutic Targets For Cerebral Ischemiamentioning

confidence: 99%

Pygmy MicroRNA: Surveillance Cops in Therapy Kingdom

Bhadra

Patra

Chhatai

et al. 2016

Mol Med

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MicroRNAs (miRNAs) are well preserved in every animal. These pygmy-sized (21-23 nt) noncoding RNAs scattered in the genome are responsible for micromanaging versatile gene regulation. There is involvement of miRNAs as surveillance cops in all human diseases including cardiovascular defects, tumor formation, reproductive pathways, and neurological and autoimmune disorders. The effective functional role of miRNA can be reduced by chemical entities of antisense oligonucleotides and versatile small molecules that support the views of novel therapies of different human diseases. In this study, we have updated our current understanding of designing and synthesizing miRNA-controlled therapeutic chemicals. We have also proposed various in vivo delivery strategies and discuss their ongoing challenges to combat incorporation hurdles in live cells and animals. Lastly, we have demonstrated the current progress of miRNA modulation in the treatment of human diseases to provide an alternative approach to gene therapy.

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Nanoparticle-Based Targeted Therapeutics in Head-And-Neck Cancer

Cited by 52 publications

References 165 publications

Biomimetic Gold Nanoshell-Loaded Macrophage for Photothermal Biomedicine

Biomimetic Gold Nanoshell-Loaded Macrophage for Photothermal Biomedicine

Evaluation of clinical effectiveness of paclitaxel and ursolic acid co-loaded liposomes as enhanced treatment for head and neck squamous cell carcinoma

Pygmy MicroRNA: Surveillance Cops in Therapy Kingdom

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