Nanoparticle based drug delivery system: Advantages and applications

Singh, Sandeep Kumar; Pandey, Vivek Kumar; Tewari, Ravi Prakash; Agarwal, Vishnu

doi:10.17485/ijst/2011/v4i3.16

Cited by 55 publications

(39 citation statements)

References 11 publications

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“…This system can be utilized for different routes of administration including oral, nasal, parenteral, etc. The drug will remain at a specific site in the right proportion for a prolonged time with less wastage and efficacy [163, 164].…”

Section: Targeted Drug Delivery Methodsmentioning

confidence: 99%

Therapeutic efficacy of nanoparticles and routes of administration

et al. 2019

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In modern-day medicine, nanotechnology and nanoparticles are some of the indispensable tools in disease monitoring and therapy. The term “nanomaterials” describes materials with nanoscale dimensions (< 100 nm) and are broadly classified into natural and synthetic nanomaterials. However, “engineered” nanomaterials have received significant attention due to their versatility. Although enormous strides have been made in research and development in the field of nanotechnology, it is often confusing for beginners to make an informed choice regarding the nanocarrier system and its potential applications. Hence, in this review, we have endeavored to briefly explain the most commonly used nanomaterials, their core properties and how surface functionalization would facilitate competent delivery of drugs or therapeutic molecules. Similarly, the suitability of carbon-based nanomaterials like CNT and QD has been discussed for targeted drug delivery and siRNA therapy. One of the biggest challenges in the formulation of drug delivery systems is fulfilling targeted/specific drug delivery, controlling drug release and preventing opsonization. Thus, a different mechanism of drug targeting, the role of suitable drug-laden nanocarrier fabrication and methods to augment drug solubility and bioavailability are discussed. Additionally, different routes of nanocarrier administration are discussed to provide greater understanding of the biological and other barriers and their impact on drug transport. The overall aim of this article is to facilitate straightforward perception of nanocarrier design, routes of various nanoparticle administration and the challenges associated with each drug delivery method.

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Section: Targeted Drug Delivery Methodsmentioning

confidence: 99%

Therapeutic efficacy of nanoparticles and routes of administration

et al. 2019

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“…Singh et al . () have enlisted several advantages of nanoparticles‐ based drug delivery such as, enhancing drug‐therapeutic efficiency and pharmacological characteristics. Nanoparticles play key role in improving pharmacokinetics, minimizing undesirable side effects, and effectively deliver to diseased sites by increasing solubility of drug, increasing drug half‐life, reducing immunogenicity, improving bioavailability, diminish drug metabolism and simultaneous delivery of two or more drugs for combination therapy (Paranjpe and Muller‐Goymann ).…”

Section: Why Nanomaterials As Antimicrobial Agents?mentioning

confidence: 99%

Nanotechnology based anti-infectives to fight microbial intrusions

et al. 2016

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SummaryWith the rise in human population across the globe especially in developing countries, the incidence of microbial infections are increasing with greater pace. On the other hand, available medication and therapies are found to be insufficient for the complete cure of such microbial infections due to the development of resistance against various antibiotics. Therefore, to cope up the menace of microbial infections and drug resistance, there is demand for new and compelling technology, which has the ability to impede these problems. Many research groups worldwide are finding a ray of hope in nanomaterials owing to their unique properties. In the present review we have discussed the reasons behind the development of new materials based on nanotechnology. It is mainly focused on pioneering studies on application of nanomaterials like carbon nanotube, fullerene, dendrimers, nanocomposite and metal nanoparticles in combating dreadful pathogens. Moreover, the concerns about their toxicity have also been discussed.

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“…The size, ζ-potential, PDI, and turbidity of the nanoparticles (0.5 mg/mL) were measured and compared with the initial values to evaluate the stability of the nanoparticles. The particle suspensions were divided into ten groups: six groups were adjusted to the desired pH values [2, 3, 5, 7, 9, 11], and using hydrochloric acid (0.1 M) or sodium hydroxide solution (0.1 M); three groups were heated to 25, 60, and 80 °C and then cooled to room temperature; another was conducted with different concentrations of sodium chloride (NaCl, 0, 10, 50, 100, 250, and 500 mM), respectively. The mixed solutions stood overnight at 25 °C.…”

Section: Methodsmentioning

confidence: 99%

“…Nanoscience and nanotechnology have the potential to provide new solutions in the development of functional substances, particularly the inclusion of bioactive compounds without affecting the sensory perception of consumers and improving the uptake of certain components [8]. Nanoparticles have several advantages [9], including promoting the solubility of hydrophobic substances [10]. Duhem et al [11] developed novel vitamin E-based nanomedicines through nanotechnologies, which offered multiple advantages in drug delivery like biocompatibility, improved drug solubility, and anticancer activity.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Tadpole- and Sphere-Shaped Hemin Nanoparticles for Enhanced Solubility

Yang

Xiong

et al. 2019

Nanoscale Res Lett

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Hemin is a potent iron supplement. A major limitation of the applicability of hemin is its extremely low aqueous solubility and bioavailability. The aim of this work is to prepare hemin nanoparticles with improved solubility. Tra nsmission electron microscopic images showed that hemin nanoparticles with different initial concentrations of hemin (0.1 and 0.5 mg/mL) were tadpole-shaped (head of approximately 200 nm and tail of 100 nm) and sphere-shaped (50–100 nm), respectively. Moreover, hemin nanoparticles exhibited higher solubility than free hemin. The solubility of sphere-shaped nanoparticles was 308.2-fold higher than that of pure hemin at 25 °C. The hemin nanoparticles were stable in acidic conditions and displayed excellent thermal stability. These results suggested that hemin nanoparticles could serve as a potential iron supplement with potential applications in the food, biomedical, and photodynamic-photothermal therapy fields. Electronic supplementary material The online version of this article (10.1186/s11671-019-2880-7) contains supplementary material, which is available to authorized users.

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Nanoparticle based drug delivery system: Advantages and applications

Cited by 55 publications

References 11 publications

Therapeutic efficacy of nanoparticles and routes of administration

Therapeutic efficacy of nanoparticles and routes of administration

Nanotechnology based anti-infectives to fight microbial intrusions

Preparation and Characterization of Tadpole- and Sphere-Shaped Hemin Nanoparticles for Enhanced Solubility

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