Nanoparticle Based Cardiac Specific Drug Delivery

Abstract

Heart failure secondary to myocardial injuries is a leading cause of death worldwide. Recently, a growing number of novel therapies have emerged for injured myocardium repairment. However, delivering therapeutic agents specifically to the injured heart remains a significant challenge. Nanoparticles are the most commonly used vehicles for targeted drug delivery. Various nanoparticles have been synthesized to deliver drugs and other therapeutic molecules to the injured heart via passive or active targeting approaches, and their targeting specificity and therapeutic efficacies have been investigated. Here, we summarized nanoparticle-based, cardiac-specific drug delivery systems, their potency for treating heart diseases, and the mechanisms underlying these cardiac-targeting strategies. We also discussed the clinical studies that have employed nanoparticle-based cardiac-specific drug delivery.

Peptide-Guided Nanoparticle Drug Delivery for Cardiomyocytes

“…Targeting strategies can be divided into two main categories, namely passive targeting and active targeting [9]. Passive targeting relies on the physicochemical properties of cells and the surrounding microenvironment in specific situations like leaky blood vessels.…”

“…However, the direct intramyocardial injection of PLGA NPs to the heart is not a convenient or safe administration approach. Intracoronary infusion, pericardial injection, epicardial delivery, intramyocardial injection, and implantable device-based delivery approaches have been used for delivering drugs specifically to the heart [9]. While these approaches have their advantages, such as increasing the local concentrations of therapeutic agents in injured hearts, they often require invasive procedures.…”

Inhibition of pulmonary artery smooth muscle cells via the delivery of curcuminoid WZ35 by Cu‐based metal organic frameworks

“…Nanotechnology is a new research hotspot in recent years, intrinsic good biological properties are widely used in drug delivery research. It can effectively achieve targeted delivery of drugs in the body, reduce the spread of drugs in normal tissues and avoid side effects [19][20][21][22]. Therefore, it will help to improve the delivery efficiency of WZ35 and ensure its suppression effect of PASMCs.…”