NanoPADs and nanoFACEs: an optically transparent nanopaper-based device for biomedical applications

Ying, Binbin; Park, Siwan; Chen, Longyan; Dong, Xianke; Young, Elton T.

doi:10.1039/d0lc00226g

Cited by 23 publications

(33 citation statements)

References 63 publications

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“…Among them, hydrogels have been utilized for the development of wearable glucose sensors ( Elsherif et al., 2018 ; Zhang et al., 2020d ). The mechanisms of hydrogel based glucose sensors are mainly based on electrochemical sensing ( Guascito et al., 2011 ; Ren et al., 2006 ; Su et al., 2013 ; Vaddiraju et al., 2009 ; Wu and Yin, 2013 ; Zhai et al., 2013 ), optical sensing ( Mesch et al., 2015 ; Suri et al., 2003 ; Vilozny et al., 2011 ; Zhang et al., 2013 , 2014 ; Kim et al., 2016b ; Wu et al., 2019b ; Ying et al., 2020b ), sensing based on geometric change ( Cambre and Sumerlin, 2011 ; Hisamitsu et al., 1997 ; Kataoka et al., 1998 ; Kitano et al., 1991a , 1991b ), and electrical sensing ( Kajisa and Sakata, 2017 ; Shang et al., 2016 ). Some mechanisms such as geometric changes have been utilized to design the glucose-responsive wearable insulin patch for regulation of blood glucose ( Lee et al., 2017 ; Wang et al., 2020a ; Yu et al., 2020a ).…”

Section: Applications Of Skin-like Hydrogel Devicesmentioning

confidence: 99%

Skin-like hydrogel devices for wearable sensing, soft robotics and beyond

Ying

2021

iScience

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112

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Summary Skin-like electronics are developing rapidly to realize a variety of applications such as wearable sensing and soft robotics. Hydrogels, as soft biomaterials, have been studied intensively for skin-like electronic utilities due to their unique features such as softness, wetness, biocompatibility and ionic sensing capability. These features could potentially blur the gap between soft biological systems and hard artificial machines. However, the development of skin-like hydrogel devices is still in its infancy and faces challenges including limited functionality, low ambient stability, poor surface adhesion, and relatively high power consumption (as ionic sensors). This review aims to summarize current development of skin-inspired hydrogel devices to address these challenges. We first conduct an overview of hydrogels and existing strategies to increase their toughness and conductivity. Next, we describe current approaches to leverage hydrogel devices with advanced merits including anti-dehydration, anti-freezing, and adhesion. Thereafter, we highlight state-of-the-art skin-like hydrogel devices for applications including wearable electronics, soft robotics, and energy harvesting. Finally, we conclude and outline the future trends.

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Section: Applications Of Skin-like Hydrogel Devicesmentioning

confidence: 99%

Skin-like hydrogel devices for wearable sensing, soft robotics and beyond

Ying

2021

iScience

Self Cite

112

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“…For instance, by combining SERS with microfluidic devices, researchers can miniaturize their laboratory setup for SERS quantification. This would allow the quantification of trace amounts of the target molecules in the microliter range of reagents, control the movement of particles in channels, decrease the assay time and number of procedures required, and offer portability. − …”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive and Reliable microRNA Detection with a Recyclable Microfluidic Device and an Easily Assembled SERS Substrate

et al. 2021

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Surface-enhanced Raman spectroscopy (SERS) detection in microfluidics is an interesting topic because of its high sensitivity, miniaturization, and ability to perform online detection. However, the difficulties in generating SERS-based microfluidic devices with uniform signal reproducibility and high sensitivity have hindered their widespread application. In addition, the recyclability of the SERS-based microfluidic devices can contribute to their broad commercialization, but the possible contamination in the detection area and cumbersome cleaning procedures remain a challenge. In this study, we describe a repeatable SERS-based microfluidic device comprising a disposable SERS substrate and a reusable microfluidic channel. The microfluidic channel was prepared via mechanical processing, and the SERS substrate was fabricated by nanoimprint lithography and electrodeposition. The SERS substrate and microfluidic channel can be attached easily because they were assembled using screws. The SERS substrate achieved an excellent SERS enhancement factor greater than 10 8 over a large sample area, signal uniformity, and substrate-to-substrate reproducibility. This guaranteed reliable and sensitive signals in every experiment. Furthermore, the disposable SERS substrate contributed exact detection of target molecules. Finally, their practical application was demonstrated with the repeated use of the microfluidic device by detecting a specific micro-RNA, (miR-34a) at a concentration as low as 5 fM.

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“…Pump-free can be realized on the nanopaper. SERS can be performed on this new platform for environmental pollutants detection [ 259 ]. A gold-coated magnetic nanoparticle with anti Microcystin-LR (MC-LR) antibody Fab fragments was produced.…”

Section: Optical Detection Methodsmentioning

confidence: 99%

Recent Advances and Applications in Paper-Based Devices for Point-of-Care Testing

Hou

Guo

et al. 2022

J. Anal. Test.

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Point-of-care testing (POCT), as a portable and user-friendly technology, can obtain accurate test results immediately at the sampling point. Nowadays, microfluidic paper-based analysis devices (μPads) have attracted the eye of the public and accelerated the development of POCT. A variety of detection methods are combined with μPads to realize precise, rapid and sensitive POCT. This article mainly introduced the development of electrochemistry and optical detection methods on μPads for POCT and their applications on disease analysis, environmental monitoring and food control in the past 5 years. Finally, the challenges and future development prospects of μPads for POCT were discussed.

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NanoPADs and nanoFACEs: an optically transparent nanopaper-based device for biomedical applications

Abstract: Paper has been one of the most popular materials of choice for biomedical applications including for bioanalysis and cell biology studies. Regular cellulose paper-based devices, however, have several key limitations...

Cited by 23 publications

References 63 publications

Skin-like hydrogel devices for wearable sensing, soft robotics and beyond

Skin-like hydrogel devices for wearable sensing, soft robotics and beyond

Highly Sensitive and Reliable microRNA Detection with a Recyclable Microfluidic Device and an Easily Assembled SERS Substrate

Recent Advances and Applications in Paper-Based Devices for Point-of-Care Testing

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