Nanometrology and its perspectives in environmental research

Kim, Hyun-A; Seo, Jungkwan; Kim, Taksoo; Lee, Byung-Tae

doi:10.5620/eht.e2014016

Cited by 8 publications

(4 citation statements)

References 35 publications

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“…The second reason is that the techniques based on light scattering like DLS require a higher concentration of NPs solution which is more likely to lead to aggregation. Consequently, these aggregated NPs have a disproportionate influence on the analytical signal (Kim et al 2014 ; Domingos et al 2009 ). The colloidal stability results showed that there was not any aggregation or change in hydrodynamic diameter of G 4 @IONPs after 28 days; it revealed that these MNPs had great colloidal stability which is a prerequisite for biomedical applications.…”

Section: Discussionmentioning

confidence: 99%

Magnetic hyperthermia of breast cancer cells and MRI relaxometry with dendrimer-coated iron-oxide nanoparticles

et al. 2018

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BackgroundRecently, some studies have focused on dendrimer nanopolymers as a magnetic resonance imaging (MRI) contrast agent or a vehicle for gene and drug delivery. Considering the suitable properties of these materials, they are appropriate candidates for coating iron-oxide nanoparticles which are applied in magnetic hyperthermia. To the best of our knowledge, the novelty of this study is the investigation of fourth-generation dendrimer-coated iron-oxide nanoparticles (G4@IONPs) in magnetic hyperthermia and MRI.MethodsIONPs were synthesized via co-precipitation and coated with the fourth generation (G4) of polyamidoamine dendrimer. The cytotoxicity of G4@IONPs with different concentrations was assessed in a human breast cancer cell line (MCF7) and human fibroblast cell line (HDF1). Hemolysis and stability of G4@IONPs were investigated, and in addition, the interaction of these particles with MCF7 cells was assessed by Prussian blue staining. Heat generation and specific absorption rate (SAR) were calculated from measurement and simulation results at 200 and 300 kHz. MCF7 and HDF1 cells were incubated with G4@IONPs for 2 h and then put into the magnetic coil for 120 min. Relaxometry experiments were performed with different concentrations of G4@IONPs with T1- and T2-weighted MR images.ResultsThe TEM results showed that G4@IONPs were 10 ± 4 nm. The in vitro toxicity assessments showed that synthesized nanoparticles had low toxicity. The viability of MCF7 cells incubated with G4@IONPs decreased significantly after magnetic hyperthermia. In addition, MR imaging revealed that G4@IONPs improved transverse relaxivity (r2) significantly.ConclusionsOur results encouraged the future application of G4@IONPs in magnetic hyperthermia and MR imaging.

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Section: Discussionmentioning

confidence: 99%

Magnetic hyperthermia of breast cancer cells and MRI relaxometry with dendrimer-coated iron-oxide nanoparticles

et al. 2018

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“…Bigger particles contribute to increasing the light scattering and shifting the measured size toward larger values. 34,35 The polydispersity of G 4 @IONPs as measured Table 2 The effect of most crucial parameters in IONPs synthesis. The effect of an increase of these parameters (in an optimum range) was shown on bare IONPs characteristics Increase 40 -- Abbreviation: IONPs, iron oxide nanoparticles.…”

Section: Discussionmentioning

confidence: 99%

Biodistribution, pharmacokinetics, and toxicity of dendrimer-coated iron oxide nanoparticles in BALB/c mice

Salimi¹,

Sarkar²,

Fathi³

et al. 2018

IJN

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BackgroundThe possibility of using a specific nanoparticle in nanomedicine highly depends on its biodistribution profile and biocompatibility. Due to growing demand for iron oxide nanoparticles (IONPs) and dendrimers in biomedical applications, this study was performed to assess the biodistribution, pharmacokinetics, and toxicity of dendrimer-coated iron oxide nanoparticles (G4@IONPs).Materials and methodsIONPs were synthesized via co-precipitation and coated with the fourth generation (G4) of polyamidoamine (PAMAM) dendrimer. To determine the biodistribution, 5 mg/mL G4@IONPs suspension was intraperitoneally injected into tumor-bearing BALB/c mice, and iron levels in blood and various organs, including the lung, liver, brain, heart, tumor, and kidney, were measured by inductively coupled plasma mass spectrometry (ICP-MS) at 4, 8, 12, and 24 h after injection. Also, to investigate the toxicity of G4@IONPs, different concentrations of G4@IONPs were injected into BALB/c mice, and blood, renal, and hepatic factors were measured. Furthermore, histopathological staining was performed to investigate the effect of G4@IONPs on the liver and kidney tissues.ResultsThe results showed that the iron content was higher in the kidney, liver, and lung tissues 24 h after injection. Toxicity assessments revealed a significant increase in blood urea nitrogen (BUN) and direct bilirubin at the concentration of 10 mg/kg. Also, in this concentration, histopathological abnormalities were detected in liver tissue.ConclusionAlthough more systematic studies are still required, our results encouraged the future investigations of G4@IONPs in biomedical applications.

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“…Obviously, the standardization of nanohybrids is necessary not only to improve our scientific understanding of the underlying fundamental processes responsible for the generated analytical signals, but is also closely linked to the quality control concepts of the systems to promote their industrial applications. Thus, the general role of nanometrology can be summarized by the following formula [79][80][81][82][83][84][85]:…”

Section: A B Cmentioning

confidence: 99%

Application of Organic-Inorganic Hybrids in Chemical Analysis, Bio- and Environmental Monitoring

et al. 2020

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Organic-inorganic hybrids (OIH) are considered to be a powerful platform for applications in many research and industrial fields. This review highlights the application of OIH for chemical analysis, biosensors, and environmental monitoring. A methodology toward metrological traceability measurement and standardization of OIH and demonstration of the role of mathematical modeling in biosensor design are also presented. The importance of the development of novel types of OIH for biosensing applications is highlighted. Finally, current trends in nanometrology and nanobiosensors are presented.

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Nanometrology and its perspectives in environmental research

Cited by 8 publications

References 35 publications

Magnetic hyperthermia of breast cancer cells and MRI relaxometry with dendrimer-coated iron-oxide nanoparticles

Magnetic hyperthermia of breast cancer cells and MRI relaxometry with dendrimer-coated iron-oxide nanoparticles

Biodistribution, pharmacokinetics, and toxicity of dendrimer-coated iron oxide nanoparticles in BALB/c mice

Application of Organic-Inorganic Hybrids in Chemical Analysis, Bio- and Environmental Monitoring

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