Nanomedicines for oral administration based on diverse nanoplatform

Novel amoxicillin nanoparticles formulated as sustained release delivery system for poultry use

“…It is generally agreed that the physicochemical properties of particle, including particle size, surface hydrophobicity, surface charge, shape, elasticity, and stability of particles in the gastrointestinal tract, play a critical role in the particle uptake of mucosal surfaces (Mao, Cun, & Kawashima, ). Depend on the physicochemical properties of amoxicillin nps, it is thought that some drugs release from the nps cross the enterocytes by passive diffusion, while other intact nps are internalized into the intestinal epithelium cell bypassing the P‐gp efflux pump, and then, both of them are transported to the systemic circulation via the portal vein (Sim et al., ). Also, NaAlg, involved in the nps formulation, is a P‐gp inhibitor (Amin, ), and it can play a role to enhance drug absorption.…”

“…Depend on the physicochemical properties of amoxicillin nps, it is thought that some drugs release from the nps cross the enterocytes by passive diffusion, while other intact nps are internalized into the intestinal epithelium cell bypassing the P-gp efflux pump, and then, both of them are transported to the systemic circulation via the portal vein (Sim et al, 2016). Also, NaAlg, involved in the nps formulation, is a P-gp inhibitor (Amin, 2013), and it can play a role to enhance drug absorption.…”

High payload itraconazole-incorporated lipid nanoparticles with modulated release property for oral and parenteral administration

“…Lipid nanoparticles (LNPs) with solid lipid core have been studied in the past few decades to improve the solubility and bioavailability of lipophilic drugs . LNPs have been investigated as an alternative nanocarrier system to their counterparts such as liposomes, micelles, nanoemulsions and polymeric nanoparticles .…”

Characterization and pharmacokinetic study of itraconazole solid dispersions prepared by solvent-controlled precipitation and spray-dry methods

“…The need for improved oral delivery systems has triggered the discovery of advanced formulations . Thermodynamic stability of the crystal lattice and poor wettability are the primary barriers to drug dissolution.…”