2022
DOI: 10.1038/s41565-022-01161-w
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Nanomedicine platform for targeting activated neutrophils and neutrophil–platelet complexes using an α1-antitrypsin-derived peptide motif

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Cited by 34 publications
(38 citation statements)
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References 52 publications
(64 reference statements)
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“…A neutrophil-targeting approach is particularly interesting for early treatment, as the thrombus does not need to be formed yet for this targeting to be effective. For instance, Cruz et al 65 recently developed a short peptide sequence (CGEAIPMSIPPEVK) with affinity for neutrophil elastase, which is only expressed by activated neutrophils. Decoration https://doi.org/10.1038/s41565-022-01270-6 of liposomes with said ligand enabled specific targeting of activated neutrophils, and subsequently promoted accumulation at the site of thrombosis.…”
Section: Targeting Of Nanoparticles To Covid-19-induced Thrombosismentioning
confidence: 99%
“…A neutrophil-targeting approach is particularly interesting for early treatment, as the thrombus does not need to be formed yet for this targeting to be effective. For instance, Cruz et al 65 recently developed a short peptide sequence (CGEAIPMSIPPEVK) with affinity for neutrophil elastase, which is only expressed by activated neutrophils. Decoration https://doi.org/10.1038/s41565-022-01270-6 of liposomes with said ligand enabled specific targeting of activated neutrophils, and subsequently promoted accumulation at the site of thrombosis.…”
Section: Targeting Of Nanoparticles To Covid-19-induced Thrombosismentioning
confidence: 99%
“…Neutrophils are an important part of the innate immune system, but they also contribute to the pathogenesis of a number of rheumatic diseases. The results of a newly published study 1 take us one step closer to the therapeutic targeting of neutrophils.…”
mentioning
confidence: 99%
“…In an interesting study published in Nature Nanotechnology 1 , Cruz and colleagues developed a nanomedicine-based platform that might eventually prove fruitful for the clinical treatment of neutrophil hyperactivity. Nanoparticles can be packaged with drugs, and the surfaces of the particles can be conjugated with ligands that specifically target them to disease-associated cells and tissues.…”
mentioning
confidence: 99%
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