The potential impact of nanomedicine on COVID-19-induced thrombosis

Russell, Peije; Esser, Lars; Hagemeyer, Christoph E.; Voelcker, Nicolas H.

doi:10.1038/s41565-022-01270-6

“…Over the past two decades, numerous types of nanoparticles have been explored for a variety of biomedical applications ranging from drug delivery to cancer therapy, biomedical imaging, nano‐vaccine, and disease diagnosis, among others [1–4] . For most of these applications, the nanoparticle‐cell interaction is the primary consideration during the design of the nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

“…Over the past two decades, numerous types of nanoparticles have been explored for a variety of biomedical applications ranging from drug delivery to cancer therapy, biomedical imaging, nano-vaccine, and disease diagnosis, among others. [1][2][3][4] For most of these applications, the nanoparticlecell interaction is the primary consideration during the design of the nanoparticles. Especially, the nanoparticle-cell membrane interaction and the subsequent cellular internalization rate and efficiency play a critical role in determining the performance of the nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Generation of a Hydrophobic Protrusion on Nanoparticles to Improve the Membrane‐Anchoring Ability and Cellular Internalization

Xia,

Zhou,

Li

et al. 2024

Angew Chem Int Ed

0

View full text Add to dashboard Cite

Controlling the nanoparticle‐cell membrane interaction to achieve easy and fast membrane anchoring and cellular internalization is of great importance in a variety of biomedical applications. Here we report a simple and versatile strategy to maneuver the nanoparticle‐cell membrane interaction by creating a tunable hydrophobic protrusion on Janus particles through swelling‐induced symmetry breaking. When the Janus particle contacts cell membrane, the protrusion will induce membrane wrapping, leading the particles to docking to the membrane, followed by drawing the whole particles into the cell. The efficiencies of both membrane anchoring and cellular internalization can be promoted by optimizing the size of the protrusion. In vitro, the Janus particles can quickly anchor to the cell membrane in 1 h and be internalized within 24 h, regardless of the types of cells involved. In vivo, the Janus particles can effectively anchor to the brain and skin tissues to provide a high retention in these tissues after intracerebroventricular, intrahippocampal, or subcutaneous injection. This strategy involving the creation of a hydrophobic protrusion on Janus particles to tune the cell‐membrane interaction holds great potential in nanoparticle‐based biomedical applications.

show abstract

“…Nanomaterials, which are approximately 1–100 nm in size, have many advantages, such as the targeting ability, good biocompatibility, stability, and extremely low toxicity ( Riehemann et al, 2009 ). Many studies have proven that nanomaterials, as therapeutic agents or drug delivery carriers, have great applications in the medical field, to treat conditions such as inflammatory diseases, infectious diseases, cardiovascular diseases, and cancer ( Kim et al, 2010 ; Psarros et al, 2012 ; Liu et al, 2018 ; Liu et al, 2019 ; Liu et al, 2020 ; Liu et al, 2021a ; Liu et al, 2021b ; Moses et al, 2021 ; Wang et al, 2022 ; Zhang et al, 2022 ; Xu et al, 2023a ; You et al, 2023 ; Russell et al, 2023 ). To date, nanotechnology-based approaches have been valid in non-invasive diagnosis and treatment of endometriosis, which effectively target ectopic tissues and cells without causing systemic effects.…”

Section: Introductionmentioning

confidence: 99%

Applications of nanomaterials in endometriosis treatment

Yuxue,

Ran,

Minghui

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Endometriosis is a common disease of the reproductive system in women of childbearing age with an unclear pathogenesis. Endometriosis mainly manifests as dysmenorrhea, abdominal pain, and infertility. Currently, medical therapy and surgical treatment are usually used for endometriosis treatment. However, due to the high recurrence rate and many complications, it has greatly affected patients’ quality of life. Nanotechnology is a new technology that mainly investigates the characteristics and applications of nanomaterials. To date, nanotechnology has received widespread attention in the field of biomedicine. Nanomaterials can not only be used as drugs to treat endometriosis directly, but also enhance the therapeutic effect of endometriosis by delivering drugs, siRNA, antibodies, vesicles, etc. This review comprehensively discusses nanomaterial-based therapies for endometriosis treatment, such as nanomaterial-based gene therapy, photothermal therapy, immunotherapy, and magnetic hyperthermia, which provides a theoretical reference for the clinical application of nanotechnology in the treatment of endometriosis.

show abstract

Generation of a Hydrophobic Protrusion on Nanoparticles to Improve the Membrane‐Anchoring Ability and Cellular Internalization

Xia,

Zhou,

Li

et al. 2024

Angewandte Chemie

0

View full text Add to dashboard Cite

Controlling the nanoparticle‐cell membrane interaction to achieve easy and fast membrane anchoring and cellular internalization is of great importance in a variety of biomedical applications. Here we report a simple and versatile strategy to maneuver the nanoparticle‐cell membrane interaction by creating a tunable hydrophobic protrusion on Janus particles through swelling‐induced symmetry breaking. When the Janus particle contacts cell membrane, the protrusion will induce membrane wrapping, leading the particles to docking to the membrane, followed by drawing the whole particles into the cell. The efficiencies of both membrane anchoring and cellular internalization can be promoted by optimizing the size of the protrusion. In vitro, the Janus particles can quickly anchor to the cell membrane in 1 h and be internalized within 24 h, regardless of the types of cells involved. In vivo, the Janus particles can effectively anchor to the brain and skin tissues to provide a high retention in these tissues after intracerebroventricular, intrahippocampal, or subcutaneous injection. This strategy involving the creation of a hydrophobic protrusion on Janus particles to tune the cell‐membrane interaction holds great potential in nanoparticle‐based biomedical applications.

show abstract

The potential impact of nanomedicine on COVID-19-induced thrombosis

Cited by 7 publications

References 121 publications

Generation of a Hydrophobic Protrusion on Nanoparticles to Improve the Membrane‐Anchoring Ability and Cellular Internalization

Generation of a Hydrophobic Protrusion on Nanoparticles to Improve the Membrane‐Anchoring Ability and Cellular Internalization

Applications of nanomaterials in endometriosis treatment

Generation of a Hydrophobic Protrusion on Nanoparticles to Improve the Membrane‐Anchoring Ability and Cellular Internalization

Contact Info

Product

Resources

About