Nanomedicine: Photo-activated nanostructured titanium dioxide, as a promising anticancer agent

Lаgopati, Nefeli; Evangelou, Konstantinos; Falaras, Polycarpos; Tsilibary, Effie Photini C.; Vasileiou, Panagiotis; Havaki, Sofia; Angelopoulou, Andriani; Pavlatou, Evangelia A.; Gorgoulis, Vassilis G.

doi:10.1016/j.pharmthera.2020.107795

Cited by 42 publications

(25 citation statements)

References 180 publications

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“…Analogous findings were obtained for FeO nanoparticles [29] as well as CeO 2 particles, with the latter having the unique feature of acting as both radio-protectors and radio-sensitizers when combined with radiotherapy [30]. TiO 2 , in turn, has been reported to be a ROS-promoting agent that, in combination with photoactivation, shows promising anticancer activity [31]. An anti-melanoma effect of Fe-TiO 2 has not been reported so far and was more pronounced in B16F0 compared to B16F10 cells.…”

Section: Discussionsupporting

confidence: 59%

Combined Toxicity of Gas Plasma Treatment and Nanoparticles Exposure in Melanoma Cells In Vitro

Bekeschus

2021

Nanomaterials

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Despite continuous advances in therapy, cancer remains a deadly disease. Over the past years, gas plasma technology emerged as a novel tool to target tumors, especially skin. Another promising anticancer approach are nanoparticles. Since combination therapies are becoming increasingly relevant in oncology, both gas plasma treatment and nanoparticle exposure were combined. A series of nanoparticles were investigated in parallel, namely, silica, silver, iron oxide, cerium oxide, titanium oxide, and iron-doped titanium oxide. For gas plasma treatment, the atmospheric pressure argon plasma jet kINPen was utilized. Using three melanoma cell lines, the two murine non-metastatic B16F0 and metastatic B16F10 cells and the human metastatic B-Raf mutant cell line SK-MEL-28, the combined cytotoxicity of both approaches was identified. The combined cytotoxicity of gas plasma treatment and nanoparticle exposure was consistent across all three cell lines for silica, silver, iron oxide, and cerium oxide. In contrast, for titanium oxide and iron-doped titanium oxide, significantly combined cytotoxicity was only observed in B16F10 cells.

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Section: Discussionsupporting

confidence: 59%

Combined Toxicity of Gas Plasma Treatment and Nanoparticles Exposure in Melanoma Cells In Vitro

Bekeschus

2021

Nanomaterials

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“…Thus, photocatalysts, such as TiO 2 are promising candidates to provide protection even against SARS-CoV-2, offering bactericidal and virucidal activity. Due to the biocompatibility and the great spectrum of anticancer and antimicrobial properties, TiO 2 is utilized in various biomedical applications, such as in drug delivery systems (DDS), in molecular imaging as well as in alternative therapeutic approaches, in parallel with conventional methods or in replacement of them (3,4).…”

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confidence: 99%

Biological Effect of Silver-modified Nanostructured Titanium Dioxide in Cancer

Lаgopati

Kotsinas

Veroutis

et al. 2021

Cancer Genomics Proteomics

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Background/Aim: Nanomedicine is a promising scientific field that exploits the unique properties of innovative nanomaterials, providing alternative solutions in diagnostics, prevention and therapeutics. Titanium dioxide nanoparticles (TiO 2 NPs) have a great spectrum of photocatalytic antibacterial and anticancer applications. The chemical modification of TiO 2 optimizes its bioactive performance. The aim of this study was the development of silver modified NPs (Ag/TiO 2 NPs) with anticancer potential. Materials and Methods: Ag/TiO 2 NPs were prepared through the sol-gel method, were fully characterized and were tested on cultured breast cancer epithelial cells (MCF-7 and MDA-MB-231). The MTT colorimetric assay was used to estimate cellular viability. Western blot analysis of protein expression along with a DNA-laddering assay were employed for apoptosis detection. Results and Conclusion: We show that photo-activated Ag/TiO 2 NPs exhibited significant cytotoxicity on the highly malignant MDA-MB-231 cancer cells, inducing apoptosis, while MCF-7 cells that are characterized by low invasive properties were unaffected under the same conditions.Nanomedicine is an emerging inter-disciplinary scientific field that exploits the unique properties of innovative 425 This article is freely accessible online.

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“…Light‐responsive NPs can be designed in an organic, polymeric, carbon‐based or inorganic frame by incorporating light‐sensitive materials, such as gold nanocomposites, photosensitizers or transitional metal materials, such as MoS 2 or WS 2 (reviewed in Mi, 2020). A range of light‐activated NPs have been designed for tumor ablation, including nanocarriers dissociation triggered by light‐cleavage of chemical bonds, light triggered alteration of molecules conformation, such as spiropyran or diazonaphtoquinone, induce formation of ROS for PDT, or induce hyperthermia in PTT (reviewed in Mi, 2020; Montaseri et al, 2020; Y. Zhang, Wang, Zhao, et al, 2020, Lagopati et al, 2020). Among these approaches, both PDT and PTT are being explored for TME stimuli‐responsive NPs (see Table 1).…”

Section: Tumor Targeting Nanomedicinementioning

confidence: 99%

“…A range of light-activated NPs have been designed for tumor ablation, including nanocarriers dissociation triggered by light-cleavage of chemical bonds, light triggered alteration of molecules conformation, such as spiropyran or diazonaphtoquinone, induce formation of ROS for PDT, or induce hyperthermia in PTT (reviewed in Mi, 2020;Montaseri et al, 2020;Y. Zhang, Wang, Zhao, et al, 2020, Lagopati et al, 2020. Among these approaches, both PDT and PTT are being explored for TME stimuliresponsive NPs (see Table 1).…”

Section: Light Activated Nanoparticlesmentioning

confidence: 99%

Combined cancer therapeutics—Tackling the complexity of the tumor microenvironment

Roma‐Rodrigues

Raposo

Valente

et al. 2021

WIREs Nanomed Nanobiotechnol

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Cancer treatment has yet to find a “silver bullet” capable of selectively and effectively kill tumor cells without damaging healthy cells. Nanomedicine is a promising field that can combine several moieties in one system to produce a multifaceted nanoplatform. The tumor microenvironment (TME) is considered responsible for the ineffectiveness of cancer therapeutics and the difficulty in the translation from the bench to bed side of novel nanomedicines. A promising approach is the use of combinatorial therapies targeting the TME with the use of stimuli‐responsive nanomaterials which would increase tumor targeting. Contemporary combined strategies for TME‐targeting nanoformulations are based on the application of external stimuli therapies, such as photothermy, hyperthermia or ultrasounds, in combination with stimuli‐responsive nanoparticles containing a core, usually composed by metal oxides or graphene, and a biocompatible stimuli‐responsive coating layer that could also contain tumor targeting moieties and a chemotherapeutic agent to enhance the therapeutic efficacy. The obstacles that nanotherapeutics must overcome in the TME to accomplish an effective therapeutic cargo delivery and the proposed strategies for improved nanotherapeutics will be reviewed. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Emerging Technologies

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Nanomedicine: Photo-activated nanostructured titanium dioxide, as a promising anticancer agent

Cited by 42 publications

References 180 publications

Combined Toxicity of Gas Plasma Treatment and Nanoparticles Exposure in Melanoma Cells In Vitro

Combined Toxicity of Gas Plasma Treatment and Nanoparticles Exposure in Melanoma Cells In Vitro

Biological Effect of Silver-modified Nanostructured Titanium Dioxide in Cancer

Combined cancer therapeutics—Tackling the complexity of the tumor microenvironment

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