Nanomedicine opened new horizons for metal nanoparticles to treat multi-drug resistant organisms

Halawani, Eman M.

doi:10.20546/ijcmas.2016.502.045

Cited by 10 publications

(2 citation statements)

References 46 publications

(64 reference statements)

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“…The chronic infections identified with biofilms are difficult to eradicate as they are able to resist both antibiotics as well as the host immune system [ 1 ]. Biofilm barrier is one of the main reasons for conversion of acute to chronic infections [ 2 ]. As indicated by the report of the national institute of health and center of disease control, approximately 65–80% diseases are caused through biofilm-inducing bacteria, predominantly through Gram-negative bacteria Pseudomonas aeruginosa and Escherichia coli and Gram-positive bacterium Staphylococcus aureus [ 3 ].…”

Section: Reviewmentioning

confidence: 99%

Nanoparticles as Efflux Pump and Biofilm Inhibitor to Rejuvenate Bactericidal Effect of Conventional Antibiotics

Gupta

Singh²,

Khan

2017

Nanoscale Res Lett

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The universal problem of bacterial resistance to antibiotic reflects a serious threat for physicians to control infections. Evolution in bacteria results in the development of various complex resistance mechanisms to neutralize the bactericidal effect of antibiotics, like drug amelioration, target modification, membrane permeability reduction, and drug extrusion through efflux pumps. Efflux pumps acquire a wide range of substrate specificity and also the tremendous efficacy for drug molecule extrusion outside bacterial cells. Hindrance in the functioning of efflux pumps may rejuvenate the bactericidal effect of conventional antibiotics. Efflux pumps also play an important role in the exclusion or inclusion of quorum-sensing biomolecules responsible for biofilm formation in bacterial cells. This transit movement of quorum-sensing biomolecules inside or outside the bacterial cells may get interrupted by impeding the functioning of efflux pumps. Metallic nanoparticles represent a potential candidate to block efflux pumps of bacterial cells. The application of nanoparticles as efflux pump inhibitors will not only help to revive the bactericidal effect of conventional antibiotics but will also assist to reduce biofilm-forming capacity of microbes. This review focuses on a novel and fascinating application of metallic nanoparticles in synergy with conventional antibiotics for efflux pump inhibition.

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Section: Reviewmentioning

confidence: 99%

Nanoparticles as Efflux Pump and Biofilm Inhibitor to Rejuvenate Bactericidal Effect of Conventional Antibiotics

Gupta

Singh²,

Khan

2017

Nanoscale Res Lett

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“…Because of their unique properties of small scale, large area-tovolume ratio, high reactivity to living cells, hightemperature stability and cell translocation, they are used in bioimaging, drug delivery and other diagnostic and therapeutic applications. Metal nanoparticles have always been used against several diseases; in the past, it found use as an antiseptic and antimicrobial against Gram-positive and Gram-negative bacteria (Halawani, 2016).…”

Section: Antibacterial Mechanisms Of Nanoparticlesmentioning

confidence: 99%

Mechanistic Insights of Actions of Metal Nanoparticles on Multidrug-Resistant Bacteria

Alzahrani¹,

Ali²,

Ahmed³

2021

OnLine Journal of Biological Sciences

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Multidrug-Resistant bacteria (MDR) are the most serious threat to public health. The number of infections caused by resistant strains is on the rise all over the world. At this time, new techniques for developing antimicrobial drugs are becoming necessary. Metallic Nanoparticles (MNPs) in the biomedical field are one of the most promising methods to overcome antibiotic resistance. Nanoparticles have recently been used as antiseptics and antimicrobials to treat a variety of diseases, including Gram-positive and Gram-negative bacteria. The disruptions caused by nanoparticles to bacterial cells include changing bacterial cell walls, denaturation of bacterial DNA and inhibition of bacterial replications. These processes are still, however, not completely understood. The DNA damage caused by Nanoparticles (NPs) results from penetrating the bacterial cell membrane due to its small size and large surface area. This action causes bacterial DNA replication to be disrupted. The use of nanoparticles still presents a therapeutic challenge and much further research is needed to solve this. This review covers the latest approaches to developing new nanobiotechnology techniques that may challenge medical practice to fight against bacteria, particularly MDR bacteria. The study also discusses the up-to-date information about the bacterial resistance mechanism against various antimicrobial agents, identifying the mechanism(s) that can be a therapeutic target. It also discusses the genetic background to silver nanoparticles resistance. 1. Introduction. 2. Mechanisms of Multi-Drug Resistance Bacteria. Antibacterial Mechanisms of Nanoparticles. Role of nanoparticles in therapeutics and drug delivery. Bacterial resistance to NPs.1 General resistance mechanisms. Bacterial resistance to silver 6. Conclusion.

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Biosynthesis of Metal and Semiconductor Nanoparticles, Scale-Up, and Their Applications

Salouti

Zonooz

2017

Nanoscience and Plant–Soil Systems

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Nanomedicine opened new horizons for metal nanoparticles to treat multi-drug resistant organisms

Cited by 10 publications

References 46 publications

Nanoparticles as Efflux Pump and Biofilm Inhibitor to Rejuvenate Bactericidal Effect of Conventional Antibiotics

Nanoparticles as Efflux Pump and Biofilm Inhibitor to Rejuvenate Bactericidal Effect of Conventional Antibiotics

Mechanistic Insights of Actions of Metal Nanoparticles on Multidrug-Resistant Bacteria

Biosynthesis of Metal and Semiconductor Nanoparticles, Scale-Up, and Their Applications

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