Nanomedicine for prostate cancer using nanoemulsion: A review

Sasikumar, Aravindsiva; Kamalasanan, Kaladhar

doi:10.1016/j.jconrel.2017.06.001

Cited by 41 publications

(27 citation statements)

References 181 publications

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“…It reduces the toxic side effects of the drugs and produces prolonged remission. Drug polymer conjugates and nanoemulsions are mainly explored for targeting prostate cancer [247]. Paclitaxel is a first-line chemotherapy drug which is commercially available as paclitaxel-cremophor (1:1) combination.…”

Section: Different Administration Routes Of Nanocarriersmentioning

confidence: 99%

Therapeutic efficacy of nanoparticles and routes of administration

et al. 2019

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In modern-day medicine, nanotechnology and nanoparticles are some of the indispensable tools in disease monitoring and therapy. The term “nanomaterials” describes materials with nanoscale dimensions (< 100 nm) and are broadly classified into natural and synthetic nanomaterials. However, “engineered” nanomaterials have received significant attention due to their versatility. Although enormous strides have been made in research and development in the field of nanotechnology, it is often confusing for beginners to make an informed choice regarding the nanocarrier system and its potential applications. Hence, in this review, we have endeavored to briefly explain the most commonly used nanomaterials, their core properties and how surface functionalization would facilitate competent delivery of drugs or therapeutic molecules. Similarly, the suitability of carbon-based nanomaterials like CNT and QD has been discussed for targeted drug delivery and siRNA therapy. One of the biggest challenges in the formulation of drug delivery systems is fulfilling targeted/specific drug delivery, controlling drug release and preventing opsonization. Thus, a different mechanism of drug targeting, the role of suitable drug-laden nanocarrier fabrication and methods to augment drug solubility and bioavailability are discussed. Additionally, different routes of nanocarrier administration are discussed to provide greater understanding of the biological and other barriers and their impact on drug transport. The overall aim of this article is to facilitate straightforward perception of nanocarrier design, routes of various nanoparticle administration and the challenges associated with each drug delivery method.

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Section: Different Administration Routes Of Nanocarriersmentioning

confidence: 99%

Therapeutic efficacy of nanoparticles and routes of administration

et al. 2019

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“…Simultaneously, nano-LSW has a good therapeutic effect on liver cancer induced by nanoDEN. The reason is that nanoliposomes exhibit good passive targeting and can selectively concentrate in the rich organizers of the reticuloendothelial system in the body (Sasikumar and Kamalasanan, 2017). Moreover, because of the enhanced permeability and retention effect (EPR), nanoliposomes build accumulation in tumors preferentially.…”

Section: Discussionmentioning

confidence: 99%

Nanoparticle-Encapsulated Liushenwan Could Treat Nanodiethylnitrosamine-Induced Liver Cancer in Mice by Interfering With Multiple Critical Factors for the Tumor Microenvironment

et al. 2020

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We previously isolated an ethanol fraction of LSW (Liushenwan pill, a traditional Chinese medicine) which has been shown to prevent and treat liver cancer induced by nanodiethylnitrosamine (nanoDEN) in mice. In the present study, we utilized a highpressure microfluidics technique to generate LSW lipid nanoparticles (nano-LSW) to reduce its toxicity, and enhance its inhibitory effect on tumor growth, and further evaluate its therapeutic effect using a nanoDEN-induced mouse model of liver cancer. Our in vitro results indicated that nano-LSW-low could induce apoptosis in HepG2 cells, but exhibited low toxicity in L02 cells. Furthermore, the in vivo results indicated that nano-LSW-low exerted minimal or no damage to normal hepatocytes, kidney, and small intestine tissues. In addition, our results showed that at the 20 th week, the inflammatory infiltration in the mice in the model group increased severely, and partial pimelosis and fibrosis occurred. In contrast, the liver tissues in the mice treated with nano-LSW exhibited only slight inflammatory infiltration, without pimelosis and fibrosis. At the 30 th week, 4 out of 5 liver tissues in the model group showed hyperplastic nodules by hematoxylin and eosin (H&E) staining. However, the liver tissues in the nano-LSW treatment group did not showed hyperplastic nodules. Immunohistochemical staining showed that, in contrast to the model group, the levels of COX-2, PCNA, b-catenin, and HMGB1 protein expressions were significantly lower in the nano-LSW-low group at the 20 th and 30 th week. Compared to model group, the COX-2, TNF-a, Smad-2, and TGF-b1 mRNA levels obviously decreased in the liver tissue after the nano-LSW-low treatment. Taken together, nano-LSW-low may serve as a potent therapeutic agent for preventing liver cancer by interfering with multiple critical factors for the tumor microenvironment during oncogenesis.

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“…The NEs exhibit unique behavior due to their nanoscopic dimensions, including remarkable stability, droplet-droplet interactions, and rheological properties. 24,25 Besides, aiming to achieve the active targeting of the drugs towards tumor cells, nanoemulsions were coated with hyaluronic acid (HA), a natural polysaccharide found in the extracellular matrix and synovial fluids of the body, that binds to specific cell receptor CD44, which is highly overexpressed in several cancers, including the oral carcinoma. [26][27][28][29] The quantitative determination of the drug incorporated into NEs is usually performed by analytical methods that need to be adequately validated to ensure a reliable quantification of the analyte.…”

Section: Application Of a New Validated Hplc-pda Methods For Simultanementioning

confidence: 99%

Application of a New Validated HPLC-PDA Method for Simultaneous Determination of Curcumin and Melatonin in Hyaluronic Acid-Coated Nanoemulsions

Vieira

Lemos‐Senna

2020

J. Braz. Chem. Soc.

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In this study, a high-performance liquid chromatography with photodiode array detector (HPLC-PDA) method was developed and validated to simultaneously determine curcumin (CUR) and melatonin (MEL) in hyaluronic acid-coated nanoemulsions, a novel targetable delivery system to CD44 receptors overexpressed in many types of tumors. Chromatographic analyses were performed in reversed phase mode using a mobile phase consisting of acetonitrile, methanol and 0.1% formic acid (35:15:50, v/v/v) at a flow rate of 1 mL min-1 , and detection at 223 and 425 nm. The method was successfully validated according to the parameters of specificity, linearity, limits of detection (LOD) and quantification (LOQ), inter/intra-day precision, accuracy, and robustness. Linearity was demonstrated in the CUR and MEL concentration range of 0.5-20.0 μg mL-1 and 1.0-40.0 μg mL-1 (r > 0.999), respectively. Relative standard deviation (RSD) values for intra-day and inter-day precision were lower than 5%, and mean drug recovery varied from 94.91 to 98.33%. Mean drug content of 85.2 and 501.4 μg mL-1 and entrapment efficiency of about 80 and 20% were obtained for CUR and MEL, respectively. These results may be correlated to the differences in the drug solubility of these drugs in the oil and water phases of the nanoemulsion.

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Nanomedicine for prostate cancer using nanoemulsion: A review

Cited by 41 publications

References 181 publications

Therapeutic efficacy of nanoparticles and routes of administration

Therapeutic efficacy of nanoparticles and routes of administration

Nanoparticle-Encapsulated Liushenwan Could Treat Nanodiethylnitrosamine-Induced Liver Cancer in Mice by Interfering With Multiple Critical Factors for the Tumor Microenvironment

Application of a New Validated HPLC-PDA Method for Simultaneous Determination of Curcumin and Melatonin in Hyaluronic Acid-Coated Nanoemulsions

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