Nanomedicine for Global Health

Abstract

Despite modern advances, a broad range of disorders such as cancer and infectious diseases continually afflict the global population. Novel therapeutics are continuously being explored to address these challenges. Therefore, scalable, effective, and safe therapies that are readily accessible to third-world countries are of major interest. In this article, we discuss the potential advantages that the nanomedicine field may harness toward successful implementation against some of the major diseases of our generation.

Extracellular Vesicles Function as Bioactive Molecular Transmitters in the Mammalian Oviduct: An Inspiration for Optimizing in Vitro Culture Systems and Improving Delivery of Exogenous Nucleic Acids during Preimplantation Embryonic Development

“…Thus, although preimplantation embryos devoid of the ZP could be transfected successfully [97], those transfected with liposomes also suffer similar shortcomings as embryos transfected by electroporation because of the absence of the ZP. The use of biocompatible nanomaterials with their large loading capacity, stability and highly specific affinity towards targeted cell populations [98,99] might prove to be a novel minimally invasive technique to deliver biomolecules into embryos, while the nonbiodegradable nature of nanomaterials limits their practical application [100]. Thus, a more effective delivery method for transfection with nucleic acids is highly desirable.…”

Theranostic Nanoparticles for Tracking and Monitoring Disease State

“…Because PPM has also been validated in the clinic, it represents a translationally relevant technology platform to optimize unmodified and nanotechnology-modified drug delivery and imaging. [90][91][92][93][94] Moreover, in addition to reconciling the disparity of dosage requirement between diagnostic and therapeutic entities within a single nanoparticle platform, such emerging technologies can be used to reconcile the differences in circulation times that will be needed to realize the potential of theranostic nanoparticles.…”

Recent Development of Metal Nanoparticles for Angiogenesis Study and Their Therapeutic Applications

“…Nanomedicine in simple terms is known as the utilization of nanotechnology in biology and medicine. In the year 2004, the European Science Foundation referred to nanomedicine as “the science and technology of diagnosing, treating, and preventing disease and traumatic injury, of relieving pain, and of preserving and improving human health, using molecular tools and molecular knowledge of the human body”. , According to the European Technology Platform, “nanomedicine is defined as the application of nanotechnology to health. It exploits the improved and often novel physical, chemical, and biological properties of materials at the nanometric scale” .…”