Nanomedicine-Based Strategies for Diabetes: Diagnostics, Monitoring, and Treatment

Lemmerman, Luke R.; Das, Devleena; Higuita‐Castro, Natalia; Mirmira, Raghavendra G.; Gallego‐Perez, Daniel

doi:10.1016/j.tem.2020.02.001

Cited by 48 publications

(18 citation statements)

References 83 publications

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“…Nanocarbon particles may be of clinical use for the treatment of non-life-threatening diseases, such as diabetes mellitus, [66][67][68][69][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85] and in bone regenerative medicine. [27,33,[86][87][88] The safety assessment approaches are exactly the same as in application (2), although the principle of therapeutic effect versus risk requires much more stringent standards.…”

Section: Administration Of Nanocarbon Particles Locally In Non-life-t...mentioning

confidence: 99%

Future Prospects for Clinical Applications of Nanocarbons Focusing on Carbon Nanotubes

et al. 2022

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Over the past 15 years, numerous studies have been conducted on the use of nanocarbons as biomaterials towards such applications as drug delivery systems, cancer therapy, and regenerative medicine. However, the clinical use of nanocarbons remains elusive, primarily due to short‐ and long‐term safety concerns. It is essential that the biosafety of each therapeutic modality be demonstrated in logical and well‐conducted experiments. Accordingly, the fundamental techniques for assessing nanocarbon biomaterial safety have become more advanced. Optimal controls are being established, nanocarbon dispersal techniques are being refined, the array of biokinetic evaluation methods has increased, and carcinogenicity examinations under strict conditions have been developed. The medical implementation of nanocarbons as a biomaterial is in sight. With a particular focus on carbon nanotubes, these perspectives aim to summarize the contributions to date on nanocarbon applications and biosafety, introduce the recent achievements in evaluation techniques, and clarify the future prospects and systematic introduction of carbon nanomaterials for clinical use through practical yet sophisticated assessment methods.

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Section: Administration Of Nanocarbon Particles Locally In Non-life-t...mentioning

confidence: 99%

Future Prospects for Clinical Applications of Nanocarbons Focusing on Carbon Nanotubes

et al. 2022

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“…Early diagnostic testing might identify individuals in need of interventions, such as lifestyle management or pharmacological approaches to prevent dysglycemia or the onset of disease‐associated complications. [ 17 ] For instance, treatment of Type‐II diabetes involves participation in physical activities and eating healthy diets. [ 18 ] Conventional methods for diabetes diagnosis are based on plasma glucose levels criteria, with a major reliance on fasting plasma glucose (FPG) levels, 2 h plasma glucose (2 h PG) levels during a 75 g oral glucose tolerance test (OGTT), or the hemoglobin‐A1c criteria.…”

Section: Nanomaterials For Diabetes Diagnosismentioning

confidence: 99%

Emerging Theranostic Nanomaterials in Diabetes and Its Complications

Liu

Zeng

et al. 2021

Advanced Science

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Diabetes mellitus (DM) refers to a group of metabolic disorders that are characterized by hyperglycemia. Oral subcutaneously administered antidiabetic drugs such as insulin, glipalamide, and metformin can temporarily balance blood sugar levels, however, long‐term administration of these therapies is associated with undesirable side effects on the kidney and liver. In addition, due to overproduction of reactive oxygen species and hyperglycemia‐induced macrovascular system damage, diabetics have an increased risk of complications. Fortunately, recent advances in nanomaterials have provided new opportunities for diabetes therapy and diagnosis. This review provides a panoramic overview of the current nanomaterials for the detection of diabetic biomarkers and diabetes treatment. Apart from diabetic sensing mechanisms and antidiabetic activities, the applications of these bioengineered nanoparticles for preventing several diabetic complications are elucidated. This review provides an overall perspective in this field, including current challenges and future trends, which may be helpful in informing the development of novel nanomaterials with new functions and properties for diabetes diagnosis and therapy.

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“…1 Acetone in exhaled breath is a key marker in the clinical diagnosis of diabetes. 2 For a healthy person, the acetone concentration in exhaled breath should be less than 0.9 ppm, while for diabetic patients, it is more than twice the normal level. 3 Therefore, the development of various high-performance acetone sensors is of great value not only in environmental monitoring but also in the field of the medical diagnosis of diabetes.…”

Section: Introductionmentioning

confidence: 99%

A ZnO/ZnFe₂O₄ n–n heterojunction and Au loading synergistically improve the sensing performance of acetone

Qin

Fan

et al. 2022

Inorg. Chem. Front.

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Nanomedicine-Based Strategies for Diabetes: Diagnostics, Monitoring, and Treatment

Cited by 48 publications

References 83 publications

Future Prospects for Clinical Applications of Nanocarbons Focusing on Carbon Nanotubes

Future Prospects for Clinical Applications of Nanocarbons Focusing on Carbon Nanotubes

Emerging Theranostic Nanomaterials in Diabetes and Its Complications

A ZnO/ZnFe₂O₄ n–n heterojunction and Au loading synergistically improve the sensing performance of acetone

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Nanomedicine-Based Strategies for Diabetes: Diagnostics, Monitoring, and Treatment

Cited by 48 publications

References 83 publications

Future Prospects for Clinical Applications of Nanocarbons Focusing on Carbon Nanotubes

Future Prospects for Clinical Applications of Nanocarbons Focusing on Carbon Nanotubes

Emerging Theranostic Nanomaterials in Diabetes and Its Complications

A ZnO/ZnFe2O4 n–n heterojunction and Au loading synergistically improve the sensing performance of acetone

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A ZnO/ZnFe₂O₄ n–n heterojunction and Au loading synergistically improve the sensing performance of acetone