Nanomedicine-Based Delivery Strategies for Breast Cancer Treatment and Management

Tagde, Priti; Najda, Agnieszka; Nagpal, Kalpana; Kulkarni, Giriraj T.; Shah, Muddaser; Ullah, Obaid; Balant, Sebastian; Rahman, Habibur

doi:10.3390/ijms23052856

Cited by 52 publications

(33 citation statements)

References 155 publications

(109 reference statements)

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“…Mucormycosis has been linked to an increase in iron levels caused by deferoxamine treatment in kidney failure (Ibrahim et al 2008 ). Steroids are widely used to treat COVID-19 and minimize damage produced by the body’s variables (Tagde et al 2022 ) (Howard 1999 ) (Akter et al 2021a ). Organ transplantation, AIDS, poorly controlled diabetes, iron overload, malignancies such as those of the immune system during coronavirus infection.…”

Section: Risk Factorsmentioning

confidence: 99%

The impact of mucormycosis (black fungus) on SARS-CoV-2-infected patients: at a glance

Islam

Rahman

Ahasan

et al. 2022

Environ Sci Pollut Res

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The emergence of various diseases during the COVID-19 pandemic made health workers more attentive, and one of the new pathogens is the black fungus (mucormycosis). As a result, millions of lives have already been lost. As a result of the mutation, the virus is constantly changing its traits, including the rate of disease transmission, virulence, pathogenesis, and clinical signs. A recent analysis revealed that some COVID-19 patients were also coinfected with a fungal disease called mucormycosis (black fungus). India has already categorized the COVID-19 patient black fungus outbreak as an epidemic. Only a few reports are observed in other countries. The immune system is weakened by COVID-19 medication, rendering it more prone to illnesses like black fungus (mucormycosis). COVID-19, which is caused by a B.1.617 strain of the SARS-CoV-2 virus, has been circulating in India since April 2021. Mucormycosis is a rare fungal infection induced by exposure to a fungus called mucormycete. The most typically implicated genera are Mucor rhyzuprhizopusdia and Cunninghamella . Mucormycosis is also known as zygomycosis. The main causes of infection are soil, dumping sites, ancient building walls, and other sources of infection (reservoir words “mucormycosis” and “zygomycosis” are occasionally interchanged). Zygomycota, on the other hand, has been identified as polyphyletic and is not currently included in fungal classification systems; also, zygomycosis includes Entomophthorales, but mucormycosis does not. This current review will be focused on the etiology and virulence factors of COVID-19/mucormycosis coinfections in COVID-19-associated mucormycosis patients, as well as their prevalence, diagnosis, and treatment. Graphical abstract

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Section: Risk Factorsmentioning

confidence: 99%

The impact of mucormycosis (black fungus) on SARS-CoV-2-infected patients: at a glance

Islam

Rahman

Ahasan

et al. 2022

Environ Sci Pollut Res

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“…(V) Appropriate application of novel materials improves the efficiency of drug targeting. Such as new nanocarrier drugs ( 98 ), which can be effectively delivered to the tissue site, so the drug dose and frequency of use can be reduced accordingly, thus reducing the toxic reactions of patients.…”

Section: Wbp2 and Breast Cancer Therapymentioning

confidence: 99%

WW domain binding protein 2 (WBP2) as an oncogene in breast cancer: mechanisms and therapeutic prospects—a narrative review

Liu¹,

He²,

Zhang³

et al. 2022

Gland Surg

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Background and Objective: WW domain binding protein 2 (WBP2), considered an emerging breast cancer gene, functions as a binding partner for WW domain proteins. The WBP2 gene is involved in mediating the malignant development and clinical drug resistance of breast cancer, but its potential mechanism remains unclear. Therefore, it is necessary to elucidate the mechanism of WBP2 in breast cancer, which will help to provide new methods for clinical diagnosis and treatment of breast cancer. Methods:The PubMed database was searched using the terms "WW Domain Binding Protein 2" or "WBP2", "breast cancer" or "breast neoplasms" or "human cancer" from January 1997 through August 2022. Through the screening and evaluation of titles and abstracts, about 120 English articles were included in this study.

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“…Various drug delivery systems have been developed to overcome the harmful side effects, drug loss and degradation, and poor bioavailability issues associated with drugs (Torchilin, 2001 ; Panyam & Labhasetwar, 2003 ). Surfactants, soluble polymers, microcapsules, cell-penetrating peptides, micelles, lipoproteins, liposomes, and microparticles made up of biodegradable natural or synthetic polymers are examples of some of the most commonly used drug carriers (Reddy & Swarnalatha, 2010 ; Tagde et al., 2022 ). Each nanocarrier has its own merits and demerits therefore, the choice of selection of nanocarrier depends on relevant considerations (Torchilin, 2001 ).…”

Section: Introductionmentioning

confidence: 99%

Investigating the self-assembling of nicotinic hydrazide-based amphiphile into nano-range vesicles and its amphotericin B loading applications

et al. 2023

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Most of the drugs are hydrophobic and have low water solubility, therefore posing issues in their absorption and bioavailability. Nonionic surfactants improve the solubility of hydrophobic drugs by entrapping them in their lipid bilayers. Two nonionic surfactants NODNH-16 and NODNH-18 are synthesized and characterized using different techniques i.e. EI-MS, 1 H NMR, and FTIR. These newly synthesized surfactants were screened for blood hemolysis assay and cell toxicity studies using the NIH/3T3 cell line to assess their biocompatibility. Then amphotericin B was loaded into niosomal vesicles, and the drug entrapment efficiency of these surfactants was measured using UV–visible spectroscopy. The morphology of drug-loaded niosomes of synthesized surfactants was investigated using AFM, and their size, polydispersity, and zeta potential were measured with the Zetasizer instrument. Finally, a simulation study was performed to determine the pattern of self-assembly of the synthesized amphiphiles. Both synthesized nonionic surfactants showed good entrapment efficiency of 60.65 ± 2.12% and 68.45 ± 2.12%, respectively. It was also confirmed that both these synthesized nonionic surfactants were safe and biocompatible and showed less blood hemolysis (i.e. 21.13 ± 2.11% and 23.32 ± 2.45%) and higher 3T3 cells’ viability at 150 µg/mL concentration as compared to Tween®-80. The antifungal potential of amphotericin B-loaded niosomes has been evaluated against unicellular multi-fungal species, which showed a promising potential for fungicidal activity. These results are substantiated by constructing a safe vehicle system for drug delivery.

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Nanomedicine-Based Delivery Strategies for Breast Cancer Treatment and Management

Cited by 52 publications

References 155 publications

The impact of mucormycosis (black fungus) on SARS-CoV-2-infected patients: at a glance

The impact of mucormycosis (black fungus) on SARS-CoV-2-infected patients: at a glance

WW domain binding protein 2 (WBP2) as an oncogene in breast cancer: mechanisms and therapeutic prospects—a narrative review

Investigating the self-assembling of nicotinic hydrazide-based amphiphile into nano-range vesicles and its amphotericin B loading applications

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