Nanomedicine advances in toxoplasmosis: diagnostic, treatment, and vaccine applications

Assolini, João Paulo; Concato, Vírgínia Márcia; Gonçalves, Manoela Daiele; Carloto, Amanda Cristina Machado; Conchon‐Costa, Ivete; Pavanelli, Wander Rogério; Melanda, Francine Nesello; Costa, Idessânia Nazareth

doi:10.1007/s00436-017-5458-2

Cited by 43 publications

(23 citation statements)

References 78 publications

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“…A review article by Assolini et al on nano-medicine advances in toxoplasmosis shows that nano-materials smaller than 1000 nm particle in size are currently being investigated as an alternative for the treatment of T. gondii infection [148]. Similarly, Adeyemi et al reported that inorganic gold, silver and platinum nanoparticles (NPs: 0.01-1,000 μg/mL) caused 90% inhibition of T. gondii growth with EC50 values of ≤7, ≤1 and ≤100 μg/mL for gold, silver, and platinum NPs, respectively [149].…”

Section: Other Biochemical Methodsmentioning

confidence: 99%

A review on inactivation methods ofToxoplasma gondiiin foods

Alizadeh

Jazaeri

Shemshadi

et al. 2018

Pathogens and Global Health

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Toxoplasmosis is an infection caused by Toxoplasma gondii, a widespread zoonotic protozoan which poses a great threat to human health and economic well-being worldwide. It is usually acquired by ingestion of water contaminated with oocysts from the feces of infected cats or by the ingestion of raw or undercooked foodstuff containing tissue cysts. The oocyst can contaminate irrigation water and fresh edible produce. It is estimated that approximately one-third of the human population worldwide harbor this parasite. Infection with T. gondii is an important cause of diseases of the central nervous system and the eye in immunocompromised and immunocompetent individuals. The purpose of this study was to evaluate the efficacy and applicability of thermal (heating, cooking, freezing and low temperature), nonthermal (high pressure processing, ionizing irradiation and curing) and chemical and biochemical (disinfection, essential oils and biochemical methods such as enzymes, nanoparticles, antibiotics and immune response) treatments for the inactivation, inhabitation or to kill T. gondii in foodstuff intended for public consumption and under experimental conditions.

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Section: Other Biochemical Methodsmentioning

confidence: 99%

A review on inactivation methods ofToxoplasma gondiiin foods

Alizadeh

Jazaeri

Shemshadi

et al. 2018

Pathogens and Global Health

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“…Nowadays, a combination of pyrimethamine and sulfadiazine with leucovorin is the first-line treatment for this disease. Although alternate therapies are also available, less toxic compounds are needed to support prolonged treatment [ 6 , 7 ].…”

Section: Toxoplasma and Toxoplasmosismentioning

confidence: 99%

A Window to Toxoplasma gondii Egress

Caldas

Souza

2018

Pathogens

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The Toxoplasma gondii cellular cycle has been widely studied in many lifecycle stages; however, the egress event still is poorly understood even though different types of molecules were shown to be involved. Assuming that there is no purpose or intentionality in biological phenomena, there is no such question as “Why does the parasite leaves the host cell”, but “Under what conditions and how?”. In this review we aimed to summarize current knowledge concerning T. gondii egress physiology (signalling pathways), structures, and route.

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“…The transmission begins with the ingestion of contaminated raw meat and then the parasite starts to infect as many cells as possible. Manifestations are highly variable, ranging from asymptomatic to severe, especially in cases of brain and eye infection (Parlog et al 2015 ; Assolini et al 2017 ). Nearly all infections are silent, and it has been shown that this parasite specifically modulates the expression of essential miRNAs in the host, altering their response to the infection (Table 1 ).…”

Section: Mirnas: Fine Modulators Of Parasitic Infectionsmentioning

confidence: 99%

Human microRNAs in host–parasite interaction: a review

et al. 2020

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MicroRNAs (miRNAs) are a group of small noncoding RNA molecules with significant capacity to regulate the gene expression at the post-transcriptional level in a sequence-specific manner either through translation repression or mRNA degradation triggering a fine-tuning biological impact. They have been implicated in several processes, including cell growth and development, signal transduction, cell proliferation and differentiation, metabolism, apoptosis, inflammation, and immune response modulation. However, over the last few years, extensive studies have shown the relevance of miRNAs in human pathophysiology. Common human parasitic diseases, such as Malaria, Leishmaniasis, Amoebiasis, Chagas disease, Schistosomiasis, Toxoplasmosis, Cryptosporidiosis, Clonorchiasis, and Echinococcosis are the leading cause of death worldwide. Thus, identifying and characterizing parasite-specific miRNAs and their host targets, as well as host-related miRNAs, are important for a deeper understanding of the pathophysiology of parasite-specific diseases at the molecular level. In this review, we have demonstrated the impact of human microRNAs during host−parasite interaction as well as their potential to be used for diagnosis and prognosis purposes.

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Nanomedicine advances in toxoplasmosis: diagnostic, treatment, and vaccine applications

Cited by 43 publications

References 78 publications

A review on inactivation methods ofToxoplasma gondiiin foods

A review on inactivation methods ofToxoplasma gondiiin foods

A Window to Toxoplasma gondii Egress

Human microRNAs in host–parasite interaction: a review

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