Nanomedicine – a promising therapy for hematological malignancies

Abstract

Nanoparticles (NPs) are used for the diagnosis and treatment of hematological tumors by loading various pharmacodynamic molecules.

Functionalization of MOF-5 with mono-substituents: effects on drug delivery behavior

“…Improvements in drug delivery systems are necessary due to the inherent properties of drugs 1 such as poor solubility, 2 poor pharmacokinetics, 3 poor biodistribution 4 and adverse side effects. 5 The use of nanotechnology to overcome such issues is constantly being updated.…”

Nanomedicine for Immunotherapy Targeting Hematological Malignancies: Current Approaches and Perspective

“…The high load and rich surface modification methods of nanomaterials provide various possibilities for improving the biocompatibility and pharmacokinetics of drugs, as well as their targeting. In addition, a nanomedicine-loading platform can load multiple drugs simultaneously and design the optimal proportion of combined drug schemes, which can improve the efficacy of drugs and reduce the occurrence of drug resistance [191].…”

“…Research about the capability of NPs as therapeutic factors still needs further evaluation and enhancement [191]. To transfer nanotechnology into nanomedicine, it is essential to know any possible toxicity caused by nanomaterials and to plan methods to decrease any damaging effects.…”

Nano-enabled theranostics for cancer

“…Nano drug carriers are principally designed to improve the selectivity to effectively target the drugs to the desired site and to reduce the immunogenicity by either coating the surface with biocompatible materials or by chemically functionalizing the surface with antibodies, peptides, cell-membrane, tunable surfactants, and natural polysaccharides. [41][42][43] These ligandmodified nanocarriers not only improve the biocompatibility but also help the drug carriers to cross certain barriers such as the cerebrospinal fluid barrier or blood-brain barrier. Ligandmodified nanocarriers possess the ability to pass through the cell membrane and deliver the drugs in a particular environment.…”