Functionalization of MOF-5 with mono-substituents: effects on drug delivery behavior

Cai, Mengru; Qin, Liuying; You, Longtai; Yao, Yu-Qing; Wu, Huimin; Zhang, Zhiqin; Zhang, Lu; Yin, Xingbin; Ni, Jian

doi:10.1039/d0ra06106a

Cited by 44 publications

(38 citation statements)

References 46 publications

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“…In addition, after 48 and 72 h of treatment, the relative cell viability decreased in a gradual trend, which is a normal phenomenon. It should be noted that, on the basis of the literature, − both MXene and MOF-5 are typically toxic nanomaterials; therefore, the obtained results of the cell viability are of great importance and a record by itself. The results of the dose-dependent MTT assay are detailed in the Supporting Information (Figures S1–S12).…”

Section: Resultsmentioning

confidence: 99%

Natural Polymers Decorated MOF-MXene Nanocarriers for Co-delivery of Doxorubicin/pCRISPR

Rabiee

Bagherzadeh

Jouyandeh

et al. 2021

ACS Appl. Bio Mater.

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A one-pot and facile method with assistance of high gravity was applied for the synthesis of inorganic two-dimensional MOF-5 embedded MXene nanostructures. The innovative inorganic MXene/MOF-5 nanostructure was applied in co-delivery of drug and gene, and to increase its bioavailability and interaction with the pCRISPR, the nanomaterial was coated with alginate and chitosan. The polymer-coated nanosystems were fully characterized, and the sustained DOX delivery and comprehensive cytotoxicity studies were conducted on the HEK-293, PC12, HepG2, and HeLa cell lines, demonstrating acceptable and excellent cell viability at both very low (0.1 μg.mL −1 ) and high (10 μg•mL −1 ) concentrations. The chitosan-coated nanocarriers showed superior relative cell viability compared to others, more than 60% on average of relative cell viability in all of the cell lines. Then, alginate-coated nanocarriers ranked at second place on the higher relative cell viability, more than 50% on average for all of the cell lines. Also, MTT results showed a complete dosedependence, and by increasing the time of treatment from 24 to 72 h, the relative cell viability decreased by a meaningful slope; however, this decrease was optimized by coating the nanocarrier with chitosan and alginate. The nanosystems were also tagged with pCRISPR to analyze the potential application in the co-delivery of drug/gene. CLSM images of the HEK-293 and HeLa cell lines unveiled successful delivery of pCRISPR into the cells, and the enhanced green fluorescent protein (EGFP) reached up to ca. 26% for the HeLa cell line. Also, a considerable drug payload of 35.7% was achieved, which would be because of the interactions between the nanocarrier and the doxorubicin. In this unprecedented report pertaining to the synthesis of MXene assisted by a MOF and high-gravity technique, the methodology and the optimized ensuing MXene/MOF-5 nanosystems can be further developed for the co-delivery of drug/gene in animal models.

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Section: Resultsmentioning

confidence: 99%

Natural Polymers Decorated MOF-MXene Nanocarriers for Co-delivery of Doxorubicin/pCRISPR

Rabiee

Bagherzadeh

Jouyandeh

et al. 2021

ACS Appl. Bio Mater.

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“…We used the solvent adsorption method to load curcumin onto IRMOF‐8, achieving a drug loading capacity of 57.85 ± 0.98 wt%. There are many potential mechanisms of interaction between curcumin and IRMOF‐8, including surface adsorption, pore encapsulation, and interaction between the host and guest [27]. In the release study, we found that the release rate of CUR@IRMOF‐8 was slow, but that it could be released continuously over a relatively long period time.…”

Section: Discussionmentioning

confidence: 96%

IRMOF‐8‐encapsulated curcumin as a biocompatible, sustained‐release nano‐preparation

Wang

Cai

Yin

et al. 2022

Applied Organom Chemis

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Metal-organic frameworks (MOFs) are porous coordination polymers formed by metal ions and organic ligands through coordination bonds. In drug delivery applications, MOFs can impart sustained release, targeting, protection of easily degradable drugs, and improved drug solubility. Isoreticular metalorganic framework-8 (IRMOF-8) is a mesoporous MOF with a network topology bridged in the form of an octahedral cluster. Compared with other materials, it has the remarkable advantages of high porosity and a regular pore structure. Curcumin (CUR) is a diketone compound with potent antitumor effects. Due to its poor solubility and stability, its clinical application is limited.Therefore, we used IRMOF-8 as a carrier for the encapsulation of CUR to overcome the shortcomings of CUR itself and expand its clinical application. In this study, IRMOF-8 was synthesized through direct mixing of triethylamine (TEA). In vitro cell experiments demonstrated the biocompatibility of IRMOF-8. Using the solvent adsorption method, CUR was encapsulated by IRMOF-8 with a drug loading content of 58.86 ± 0.98 wt%. In vitro drug release experiments performed at pH levels of 7.2 and 5.5 showed that the preparation had a sustained-release effect over 7 days. Through cytotoxicity experiments after drug loading, it was found that CUR@IRMOF-8 had a strong cytotoxic effect on HepG2 cells, promoted cell apoptosis and intracellular uptake, decreased mitochondrial membrane potential, and increased reactive oxygen species. Hence,

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“…Metal-organic frameworks (MOFs) 1,2 have gained immense scientific interest for the construction of novel geometrical architectures in stable crystalline functional materials, which are applicable in fields including gas storage and separation, [3][4][5] catalysis, [6][7][8][9] ion exchange, 10,11 magnetism, [12][13][14][15] and drug delivery. [16][17][18][19] Among various applications, luminescence sensing based on luminescent MOFs has attracted significant attention due to their high selectivity, quick response, operability, and reversibility. 1,[20][21][22] A synthesized MOF can simultaneously detect multiple types of organic small molecules (such as explosives, antibiotics, amino acids, etc.…”

Section: Introductionmentioning

confidence: 99%

Three-fold interpenetrated metal–organic framework as a multifunctional fluorescent probe for detecting 2,4,6-trinitrophenol, levofloxacin, and l-cystine

et al. 2022

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Functionalization of MOF-5 with mono-substituents: effects on drug delivery behavior

Abstract: Metal organic frameworks (MOFs) are widely used in drug carrier research due to their tunability.

Cited by 44 publications

References 46 publications

Natural Polymers Decorated MOF-MXene Nanocarriers for Co-delivery of Doxorubicin/pCRISPR

Natural Polymers Decorated MOF-MXene Nanocarriers for Co-delivery of Doxorubicin/pCRISPR

IRMOF‐8‐encapsulated curcumin as a biocompatible, sustained‐release nano‐preparation

Three-fold interpenetrated metal–organic framework as a multifunctional fluorescent probe for detecting 2,4,6-trinitrophenol, levofloxacin, and l-cystine

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