Nanomechanics of Amyloid Materials Studied by Atomic Force Microscopy

Zeng, Gang; Duan, Yusheng; Besenbacher, Flemming; Dong, Mingdong

doi:10.5772/36342

Cited by 3 publications

(2 citation statements)

References 78 publications

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“…Especially, the species of hIAPP fibrils exhibit an obviously improved effect on Young's modulus of hybrid amyloid strain. In essence, the variation in Young's modulus might indicate the different internal packing densities and the intermolecular interactions between amyloid proteins [52][53][54]. The low Young's modulus values infer a relatively lower packing density inside cross-fibrils, and vice versa.…”

Section: Resultsmentioning

confidence: 99%

Identification of hybrid amyloid strains assembled from amyloid-β and human islet amyloid polypeptide

Wu,

Wang,

Jia

et al. 2023

Nanotechnology

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Cross-fibrillation of amyloid-β (Aβ) peptides and human islet amyloid polypeptides (hIAPP) has revealed a close correlation between Alzheimer’s disease (AD) and type 2 diabetes (T2D). Importantly, different amyloid strains are likely to lead to the clinical pathological heterogeneity of degenerative diseases due to toxicity. However, given the complicated cross-interactions between different amyloid peptides, it is still challenging to identify the polymorphism of the hybrid amyloid strains and reveal mechanistic insights into aggregation, but highly anticipated due to their significance. In this study, we investigated the cross-fibrillation of Aβ peptides and different hIAPP species (monomers, oligomers, and fibrils) using combined experimental and simulation approaches. Cross-seeding and propagation of different amyloid peptides monitored by experimental techniques proved that the three species of hIAPP aggregates have successively enhanced Aβ fibrillation, especially for hIAPP fibrils. Moreover, the polymorphism of these morphologically similar hybrid amyloid strains could be distinguished by testing their mechanical properties using quantitative nanomechanical mapping, where the assemblies of Aβ-hIAPP fibrils exhibited the high Young’s modulus. Furthermore, the enhanced internal molecular interactions and β-sheet structural transformation were proved by exploring the conformational ensembles of Aβ-hIAPP heterodimer and Aβ-hIAPP decamer using molecular dynamic simulations. Our findings pave the way for identifying different hybrid amyloid strains by quantitative nanomechanical mapping and molecular dynamic simulations, which is important not only for the precise classification of neurodegenerative disease subtypes but also for future molecular diagnosis and therapeutic treatment of multiple interrelated degenerative diseases.

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Section: Resultsmentioning

confidence: 99%

Identification of hybrid amyloid strains assembled from amyloid-β and human islet amyloid polypeptide

Wu,

Wang,

Jia

et al. 2023

Nanotechnology

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show abstract

“…AFM is usually used to indent the surface morphology and topography typically in highresolution tapping mode, which permits nano-indentation to be performed, measuring the mechanical properties of tested samples [122]. The basic principle of AFM involves a fine tip being scanned across the surface of the sample to measure surface morphology and properties to construct a 3D image of the surface.…”

Section: Atomic Force Microscopy (Afm)mentioning

confidence: 99%

Development of Hybrid Sol-Gel Coatings on AA2024-T3 with Environmentally Benign Corrosion Inhibitors

Mussa¹

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Aluminium alloys are still considered as one of the primary light alloys with high strength that can be used in aerospace and marine structure with a moderate economic cost. However, aluminium alloys are affected by atmospheric and marine corrosion which reduces their overall reliability. The application of coatings is one of the strategies for mitigating the corrosion on aluminium alloys. Sol-gel technology is one of the coating strategies with potential for excellent chemical and environment stability, providing eco-friendly performance improvement. Sol-gel coatings can enhance corrosion resistance by adopting many corrosion inhibitors that can protect aluminium alloys substrates from corrosion.

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Behavior of Bitumen-coated Fine Solids in Organic Media from Non-aqueous Extraction of Oil Sands

Liu¹

2019

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Nanomechanics of Amyloid Materials Studied by Atomic Force Microscopy

Cited by 3 publications

References 78 publications

Identification of hybrid amyloid strains assembled from amyloid-β and human islet amyloid polypeptide

Identification of hybrid amyloid strains assembled from amyloid-β and human islet amyloid polypeptide

Development of Hybrid Sol-Gel Coatings on AA2024-T3 with Environmentally Benign Corrosion Inhibitors

Behavior of Bitumen-coated Fine Solids in Organic Media from Non-aqueous Extraction of Oil Sands

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